Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study
Objective: To evaluate the efficacy of oral micronized progesterone compared with IM progesterone in oil for luteal support in patients undergoing IVF who are treated with a GnRH agonist. Design: Randomized prospective clinical trial. Setting: University-based IVF center. Patient(s): Women
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| Veröffentlicht in: | Fertility and sterility 1999-04, Vol.71 (4), p.614-618 |
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| container_title | Fertility and sterility |
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| creator | Licciardi, Frederick L Kwiatkowski, Andrea Noyes, Nicole L Berkeley, Alan S Krey, Lewis L Grifo, Jamie A |
| description | Objective: To evaluate the efficacy of oral micronized progesterone compared with IM progesterone in oil for luteal support in patients undergoing IVF who are treated with a GnRH agonist.
Design: Randomized prospective clinical trial.
Setting: University-based IVF center.
Patient(s): Women |
| doi_str_mv | 10.1016/S0015-0282(98)00515-9 |
| format | Article |
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Design: Randomized prospective clinical trial.
Setting: University-based IVF center.
Patient(s): Women <40 years of age who were undergoing IVF with luteal GnRH pituitary down-regulation.
Intervention(s): Patients were randomized to receive either oral micronized progesterone (200 mg three times daily) or IM progesterone (50 mg daily).
Main Outcome Measure(s): Progesterone levels at standardized days 21 and 28, and pregnancy and embryo implantation rates.
Result(s): Day 21 progesterone levels were 77.6 ± 13.2 ng/mL in the IM group and 81.5 ± 16.2 ng/mL in the oral group. Day 28 progesterone levels were 76.3 ± 15.0 ng/mL in the IM group and 53.6 ± 10.1 ng/mL in the oral group. The clinical pregnancy rates were 57.9% and 45.8% for the IM and oral groups, respectively. The implantation rate per embryo was significantly higher in the IM group (40.9%) than in the oral group (18.1%).
Conclusion(s): When used according to our protocols, oral progesterone and IM progesterone result in comparable levels of circulating progesterone. However, oral progesterone results in a reduced implantation rate per embryo.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(98)00515-9</identifier><identifier>PMID: 10202868</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Oral ; Adult ; Biological and medical sciences ; Embryo Implantation ; Embryo Transfer ; Female ; Fertilization in Vitro ; Hormones. Endocrine system ; Humans ; implantation ; in vitro fertilization ; Injections, Intramuscular ; Medical sciences ; Oral micronized progesterone ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy Outcome ; Progesterone - administration & dosage ; Progesterone - blood ; Prospective Studies</subject><ispartof>Fertility and sterility, 1999-04, Vol.71 (4), p.614-618</ispartof><rights>1999 American Society for Reproductive Medicine</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-c72e347774aacff0775e6f99d52a3862f490e49ff7696610cc624f7e5c5062b63</citedby><cites>FETCH-LOGICAL-c437t-c72e347774aacff0775e6f99d52a3862f490e49ff7696610cc624f7e5c5062b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(98)00515-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>310,311,315,782,786,791,792,3552,23937,23938,25147,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1911764$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10202868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Licciardi, Frederick L</creatorcontrib><creatorcontrib>Kwiatkowski, Andrea</creatorcontrib><creatorcontrib>Noyes, Nicole L</creatorcontrib><creatorcontrib>Berkeley, Alan S</creatorcontrib><creatorcontrib>Krey, Lewis L</creatorcontrib><creatorcontrib>Grifo, Jamie A</creatorcontrib><title>Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective: To evaluate the efficacy of oral micronized progesterone compared with IM progesterone in oil for luteal support in patients undergoing IVF who are treated with a GnRH agonist.
Design: Randomized prospective clinical trial.
Setting: University-based IVF center.
Patient(s): Women <40 years of age who were undergoing IVF with luteal GnRH pituitary down-regulation.
Intervention(s): Patients were randomized to receive either oral micronized progesterone (200 mg three times daily) or IM progesterone (50 mg daily).
Main Outcome Measure(s): Progesterone levels at standardized days 21 and 28, and pregnancy and embryo implantation rates.
Result(s): Day 21 progesterone levels were 77.6 ± 13.2 ng/mL in the IM group and 81.5 ± 16.2 ng/mL in the oral group. Day 28 progesterone levels were 76.3 ± 15.0 ng/mL in the IM group and 53.6 ± 10.1 ng/mL in the oral group. The clinical pregnancy rates were 57.9% and 45.8% for the IM and oral groups, respectively. The implantation rate per embryo was significantly higher in the IM group (40.9%) than in the oral group (18.1%).
Conclusion(s): When used according to our protocols, oral progesterone and IM progesterone result in comparable levels of circulating progesterone. However, oral progesterone results in a reduced implantation rate per embryo.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Embryo Implantation</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>implantation</subject><subject>in vitro fertilization</subject><subject>Injections, Intramuscular</subject><subject>Medical sciences</subject><subject>Oral micronized progesterone</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Progesterone - administration & dosage</subject><subject>Progesterone - blood</subject><subject>Prospective Studies</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PAyEURYnR2Fr9CRoWxuhiFJgBBjfGNH4lJi7UNaHMw2Dmo8JMk_rrpbZRd67Ig3MfNwehQ0rOKaHi4pkQyjPCSnaqyjNCeJrUFhpTzkXGBc-30fgHGaG9GN8JIYJKtotGlLB0LcoxMk_B1HgBIQ4R-7YPphmiHWoT8Dx0bxB7CF0L2HUhPeOF70OHHYTe1_7T9L5rL7FZoXEOtvcLwMG0Vdf4T6hw7IdquY92nKkjHGzOCXq9vXmZ3mePT3cP0-vHzBa57DMrGeSFlLIwxjpHpOQgnFIVZyYvBXOFIlAo56RQQlBirWCFk8AtJ4LNRD5BJ-u9qczHkIrrxkcLdW1a6IaoU6yUjMsE8jVoU-sYwOl58I0JS02JXrnV3271SpxWpf52q1XKHW0-GGYNVH9Sa5kJON4AJlpTu2TC-vjLKUqlKBJ2tcYg2Vh4CDpaD62FyofkUFed_6fJFxUhl0c</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Licciardi, Frederick L</creator><creator>Kwiatkowski, Andrea</creator><creator>Noyes, Nicole L</creator><creator>Berkeley, Alan S</creator><creator>Krey, Lewis L</creator><creator>Grifo, Jamie A</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study</title><author>Licciardi, Frederick L ; Kwiatkowski, Andrea ; Noyes, Nicole L ; Berkeley, Alan S ; Krey, Lewis L ; Grifo, Jamie A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-c72e347774aacff0775e6f99d52a3862f490e49ff7696610cc624f7e5c5062b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Embryo Implantation</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>implantation</topic><topic>in vitro fertilization</topic><topic>Injections, Intramuscular</topic><topic>Medical sciences</topic><topic>Oral micronized progesterone</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Progesterone - administration & dosage</topic><topic>Progesterone - blood</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Licciardi, Frederick L</creatorcontrib><creatorcontrib>Kwiatkowski, Andrea</creatorcontrib><creatorcontrib>Noyes, Nicole L</creatorcontrib><creatorcontrib>Berkeley, Alan S</creatorcontrib><creatorcontrib>Krey, Lewis L</creatorcontrib><creatorcontrib>Grifo, Jamie A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Licciardi, Frederick L</au><au>Kwiatkowski, Andrea</au><au>Noyes, Nicole L</au><au>Berkeley, Alan S</au><au>Krey, Lewis L</au><au>Grifo, Jamie A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>71</volume><issue>4</issue><spage>614</spage><epage>618</epage><pages>614-618</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective: To evaluate the efficacy of oral micronized progesterone compared with IM progesterone in oil for luteal support in patients undergoing IVF who are treated with a GnRH agonist.
Design: Randomized prospective clinical trial.
Setting: University-based IVF center.
Patient(s): Women <40 years of age who were undergoing IVF with luteal GnRH pituitary down-regulation.
Intervention(s): Patients were randomized to receive either oral micronized progesterone (200 mg three times daily) or IM progesterone (50 mg daily).
Main Outcome Measure(s): Progesterone levels at standardized days 21 and 28, and pregnancy and embryo implantation rates.
Result(s): Day 21 progesterone levels were 77.6 ± 13.2 ng/mL in the IM group and 81.5 ± 16.2 ng/mL in the oral group. Day 28 progesterone levels were 76.3 ± 15.0 ng/mL in the IM group and 53.6 ± 10.1 ng/mL in the oral group. The clinical pregnancy rates were 57.9% and 45.8% for the IM and oral groups, respectively. The implantation rate per embryo was significantly higher in the IM group (40.9%) than in the oral group (18.1%).
Conclusion(s): When used according to our protocols, oral progesterone and IM progesterone result in comparable levels of circulating progesterone. However, oral progesterone results in a reduced implantation rate per embryo.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10202868</pmid><doi>10.1016/S0015-0282(98)00515-9</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier); Alma/SFX Local Collection |
| subjects | Administration, Oral Adult Biological and medical sciences Embryo Implantation Embryo Transfer Female Fertilization in Vitro Hormones. Endocrine system Humans implantation in vitro fertilization Injections, Intramuscular Medical sciences Oral micronized progesterone Pharmacology. Drug treatments Pregnancy Pregnancy Outcome Progesterone - administration & dosage Progesterone - blood Prospective Studies |
| title | Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study |
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