EM Visualization of Transcription by RNA Polymerase II: Downstream Termination Requires a Poly(A) Signal but Not Transcript Cleavage

We have used EM visualization of active genes on plasmid vectors in Xenopus oocyte nuclei to investigate the relationship between poly(A) signals and RNA polymerase II transcription termination. Although a functional poly(A) signal is required for efficient termination, cotranscriptional RNA cleavag...

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Veröffentlicht in:	Molecular cell 1999-03, Vol.3 (3), p.379-387
Hauptverfasser:	Osheim, Yvonne N, Proudfoot, Nick J, Beyer, Ann L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA-Binding Proteins - genetics Genes - genetics Microscopy, Electron Oocytes - metabolism Plasmids - genetics Plasmids - ultrastructure Poly A - genetics Promoter Regions, Genetic - genetics Response Elements - genetics RNA Polymerase II - metabolism RNA, Messenger - metabolism RNA, Messenger - ultrastructure Templates, Genetic Transcription Factor TFIIIA Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - genetics Xenopus Xenopus laevis
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