Physical Mapping of a Tandem Duplication on the Long Arm of Chromosome 7 Associated with a Multidrug Resistant Phenotype

Both the expression of the multidrug transporter, P-glycoprotein (Pgp), and abnormalities of the long arm of chromosome 7 have been shown to be adverse prognostic indicators in acute leukemias. In this study, a clonal duplication, dup(7)(q11.1q31.1), inherited with the classical multidrug resistant...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1999-04, Vol.110 (1), p.28-33
Hauptverfasser:	de Silva, Michelle G, Kantharidis, Phillip, Scherer, Stephen W, Rayeroux, Kathleen, Campbell, Lynda, Tsui, Lap-Chee, Zalcberg, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics Biological and medical sciences Chromosome Aberrations Chromosomes, Human, Pair 7 Drug Resistance, Multiple - genetics Hematologic and hematopoietic diseases Humans Leukemia, T-Cell - drug therapy Leukemia, T-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Phenotype Physical Chromosome Mapping Tumor Cells, Cultured
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