Increase in Expression of Adhesion Molecule Receptors on T Helper Cells During Antipsychotic Treatment and Relationship to Blood-Brain Barrier Permeability in Schizophrenia
OBJECTIVE: The authors estimated the expression of adhesion molecule receptors (VLA-4 and LFA-1) on T helper (CD4+) and T suppressor cytotoxic (CD8+) lymphocytes in schizophrenic patients before and during antipsychotic treatment and studied the relationship of these subpopulations to CSF measures a...
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| Veröffentlicht in: | The American journal of psychiatry 1999-04, Vol.156 (4), p.634-636 |
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| container_title | The American journal of psychiatry |
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| creator | M�ller, Norbert Riedel, Michael Hadjamu, Myriam Schwarz, Markus J. Ackenheil, Manfred Gruber, Rudolf |
| description | OBJECTIVE: The authors estimated the expression of adhesion molecule receptors (VLA-4 and LFA-1) on T helper (CD4+) and T suppressor cytotoxic (CD8+) lymphocytes in schizophrenic patients before and during antipsychotic treatment and studied the relationship of these subpopulations to CSF measures and blood-brain barrier permeability. METHOD: Blood was drawn from hospitalized patients with schizophrenia before (N=45) and after (N=22) neuroleptic treatment and from an age-matched comparison group (N=41). Lumbar punctures were performed on 32 of the schizophrenic patients. RESULTS: During antipsychotic treatment there were significant increases in the percentages of VLA-4+ CD4+ and VLA-4+ CD8+ cells. VLA-4+ CD4+ and LFA-1+ CD4+ cells were both closely related to disturbance of the blood-brain barrier. Higher values for VLA-4+ CD4+ and LFA-1+ CD4+ cells were found in patients with a disturbed blood-brain barrier. CONCLUSIONS: The findings suggest that adhesion molecules are involved in immunoregulation between the central nervous system and the peripheral immune system in schizophrenia. |
| doi_str_mv | 10.1176/ajp.156.4.634 |
| format | Article |
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METHOD: Blood was drawn from hospitalized patients with schizophrenia before (N=45) and after (N=22) neuroleptic treatment and from an age-matched comparison group (N=41). Lumbar punctures were performed on 32 of the schizophrenic patients. RESULTS: During antipsychotic treatment there were significant increases in the percentages of VLA-4+ CD4+ and VLA-4+ CD8+ cells. VLA-4+ CD4+ and LFA-1+ CD4+ cells were both closely related to disturbance of the blood-brain barrier. Higher values for VLA-4+ CD4+ and LFA-1+ CD4+ cells were found in patients with a disturbed blood-brain barrier. CONCLUSIONS: The findings suggest that adhesion molecules are involved in immunoregulation between the central nervous system and the peripheral immune system in schizophrenia.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.156.4.634</identifier><identifier>PMID: 10200747</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; AIDS/HIV ; Antipsychotic Agents - pharmacology ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Blood ; Blood-Brain Barrier - drug effects ; Blood-Brain Barrier - physiology ; Brain ; CD4-Positive T-Lymphocytes - drug effects ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - metabolism ; CD8-Positive T-Lymphocytes - drug effects ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - metabolism ; Cell Adhesion Molecules - analysis ; Cell Adhesion Molecules - metabolism ; Female ; Humans ; Immune system ; Integrin alpha4beta1 ; Integrins - analysis ; Integrins - metabolism ; Male ; Medical sciences ; Nervous system ; Neuropharmacology ; Permeability - drug effects ; Pharmacology. Drug treatments ; Prescription drugs ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Receptors, Lymphocyte Homing - analysis ; Receptors, Lymphocyte Homing - metabolism ; Receptors, Very Late Antigen - analysis ; Receptors, Very Late Antigen - metabolism ; Schizophrenia ; Schizophrenia - blood ; Schizophrenia - drug therapy ; Schizophrenia - metabolism ; T-Lymphocytes, Helper-Inducer - chemistry ; T-Lymphocytes, Helper-Inducer - drug effects ; T-Lymphocytes, Helper-Inducer - metabolism ; Vascular Cell Adhesion Molecule-1 - analysis ; Vascular Cell Adhesion Molecule-1 - metabolism</subject><ispartof>The American journal of psychiatry, 1999-04, Vol.156 (4), p.634-636</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Apr 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a408t-5a6316ca38dd338afab49c3ab839b621277c87f0c94cc46dc185bacc7b1801b53</citedby><cites>FETCH-LOGICAL-a408t-5a6316ca38dd338afab49c3ab839b621277c87f0c94cc46dc185bacc7b1801b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.156.4.634$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.156.4.634$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2855,21626,21627,21628,27869,27924,27925,77794,77799</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1755506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10200747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>M�ller, Norbert</creatorcontrib><creatorcontrib>Riedel, Michael</creatorcontrib><creatorcontrib>Hadjamu, Myriam</creatorcontrib><creatorcontrib>Schwarz, Markus J.</creatorcontrib><creatorcontrib>Ackenheil, Manfred</creatorcontrib><creatorcontrib>Gruber, Rudolf</creatorcontrib><title>Increase in Expression of Adhesion Molecule Receptors on T Helper Cells During Antipsychotic Treatment and Relationship to Blood-Brain Barrier Permeability in Schizophrenia</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: The authors estimated the expression of adhesion molecule receptors (VLA-4 and LFA-1) on T helper (CD4+) and T suppressor cytotoxic (CD8+) lymphocytes in schizophrenic patients before and during antipsychotic treatment and studied the relationship of these subpopulations to CSF measures and blood-brain barrier permeability. METHOD: Blood was drawn from hospitalized patients with schizophrenia before (N=45) and after (N=22) neuroleptic treatment and from an age-matched comparison group (N=41). Lumbar punctures were performed on 32 of the schizophrenic patients. RESULTS: During antipsychotic treatment there were significant increases in the percentages of VLA-4+ CD4+ and VLA-4+ CD8+ cells. VLA-4+ CD4+ and LFA-1+ CD4+ cells were both closely related to disturbance of the blood-brain barrier. Higher values for VLA-4+ CD4+ and LFA-1+ CD4+ cells were found in patients with a disturbed blood-brain barrier. CONCLUSIONS: The findings suggest that adhesion molecules are involved in immunoregulation between the central nervous system and the peripheral immune system in schizophrenia.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>CD8-Positive T-Lymphocytes - drug effects</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Cell Adhesion Molecules - analysis</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immune system</subject><subject>Integrin alpha4beta1</subject><subject>Integrins - analysis</subject><subject>Integrins - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Neuropharmacology</subject><subject>Permeability - drug effects</subject><subject>Pharmacology. 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Psychiatry</topic><topic>Psychopharmacology</topic><topic>Receptors, Lymphocyte Homing - analysis</topic><topic>Receptors, Lymphocyte Homing - metabolism</topic><topic>Receptors, Very Late Antigen - analysis</topic><topic>Receptors, Very Late Antigen - metabolism</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - metabolism</topic><topic>T-Lymphocytes, Helper-Inducer - chemistry</topic><topic>T-Lymphocytes, Helper-Inducer - drug effects</topic><topic>T-Lymphocytes, Helper-Inducer - metabolism</topic><topic>Vascular Cell Adhesion Molecule-1 - analysis</topic><topic>Vascular Cell Adhesion Molecule-1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>M�ller, Norbert</creatorcontrib><creatorcontrib>Riedel, Michael</creatorcontrib><creatorcontrib>Hadjamu, Myriam</creatorcontrib><creatorcontrib>Schwarz, Markus J.</creatorcontrib><creatorcontrib>Ackenheil, Manfred</creatorcontrib><creatorcontrib>Gruber, Rudolf</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 13</collection><collection>Periodicals Index Online Segment 14</collection><collection>Periodicals Index Online Segment 27</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - 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METHOD: Blood was drawn from hospitalized patients with schizophrenia before (N=45) and after (N=22) neuroleptic treatment and from an age-matched comparison group (N=41). Lumbar punctures were performed on 32 of the schizophrenic patients. RESULTS: During antipsychotic treatment there were significant increases in the percentages of VLA-4+ CD4+ and VLA-4+ CD8+ cells. VLA-4+ CD4+ and LFA-1+ CD4+ cells were both closely related to disturbance of the blood-brain barrier. Higher values for VLA-4+ CD4+ and LFA-1+ CD4+ cells were found in patients with a disturbed blood-brain barrier. CONCLUSIONS: The findings suggest that adhesion molecules are involved in immunoregulation between the central nervous system and the peripheral immune system in schizophrenia.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>10200747</pmid><doi>10.1176/ajp.156.4.634</doi><tpages>3</tpages></addata></record> |
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| ispartof | The American journal of psychiatry, 1999-04, Vol.156 (4), p.634-636 |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); Periodicals Index Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult AIDS/HIV Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Biological and medical sciences Blood Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Brain CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Adhesion Molecules - analysis Cell Adhesion Molecules - metabolism Female Humans Immune system Integrin alpha4beta1 Integrins - analysis Integrins - metabolism Male Medical sciences Nervous system Neuropharmacology Permeability - drug effects Pharmacology. Drug treatments Prescription drugs Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors, Lymphocyte Homing - analysis Receptors, Lymphocyte Homing - metabolism Receptors, Very Late Antigen - analysis Receptors, Very Late Antigen - metabolism Schizophrenia Schizophrenia - blood Schizophrenia - drug therapy Schizophrenia - metabolism T-Lymphocytes, Helper-Inducer - chemistry T-Lymphocytes, Helper-Inducer - drug effects T-Lymphocytes, Helper-Inducer - metabolism Vascular Cell Adhesion Molecule-1 - analysis Vascular Cell Adhesion Molecule-1 - metabolism |
| title | Increase in Expression of Adhesion Molecule Receptors on T Helper Cells During Antipsychotic Treatment and Relationship to Blood-Brain Barrier Permeability in Schizophrenia |
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