An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms—A tool for quantitative assessment of hydrogel formation processes
Controlled release (CR) dosage forms are often based on polymeric matrices, e.g., sustained-release tablets and capsules. It is crucial to visualise and quantify processes of the hydrogel formation during the standard dissolution study. A method for imaging of CR, polymer-based dosage forms during d...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2008-11, Vol.48 (3), p.685-693 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Kulinowski, Piotr Dorożyński, Przemysław Jachowicz, Renata Węglarz, Władysław P. |
| description | Controlled release (CR) dosage forms are often based on polymeric matrices, e.g., sustained-release tablets and capsules. It is crucial to visualise and quantify processes of the hydrogel formation during the standard dissolution study. A method for imaging of CR, polymer-based dosage forms during dissolution study
in vitro is presented. Imaging was performed in a non-invasive way by means of the magnetic resonance imaging (MRI). This study was designed to simulate
in vivo conditions regarding temperature, volume, state and composition of dissolution media. Two formulations of hydrodynamically balanced systems (HBS) were chosen as model CR dosage forms. HBS release active substance in stomach while floating on the surface of the gastric content. Time evolutions of the diffusion region, hydrogel formation region and “dry core” region were obtained during a dissolution study of L-dopa as a model drug in two simulated gastric fluids (i.e. in fed and fasted state). This method seems to be a very promising tool for examining properties of new formulations of CR, polymer-based dosage forms or for comparison of generic and originator dosage forms before carrying out bioequivalence studies. |
| doi_str_mv | 10.1016/j.jpba.2008.06.025 |
| format | Article |
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in vitro is presented. Imaging was performed in a non-invasive way by means of the magnetic resonance imaging (MRI). This study was designed to simulate
in vivo conditions regarding temperature, volume, state and composition of dissolution media. Two formulations of hydrodynamically balanced systems (HBS) were chosen as model CR dosage forms. HBS release active substance in stomach while floating on the surface of the gastric content. Time evolutions of the diffusion region, hydrogel formation region and “dry core” region were obtained during a dissolution study of L-dopa as a model drug in two simulated gastric fluids (i.e. in fed and fasted state). This method seems to be a very promising tool for examining properties of new formulations of CR, polymer-based dosage forms or for comparison of generic and originator dosage forms before carrying out bioequivalence studies.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2008.06.025</identifier><identifier>PMID: 18715732</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Capsules ; Chemistry, Pharmaceutical ; Computer Simulation ; Controlled release dosage forms ; Delayed-Action Preparations - chemistry ; Diffusion ; Dosage Forms ; Drug Combinations ; Equipment Design ; Fasting - metabolism ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Hydrodynamically balanced systems ; Hydrogel formation ; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry ; Hydrogen-Ion Concentration ; Hypromellose Derivatives ; Levodopa - administration & dosage ; Levodopa - pharmacokinetics ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical sciences ; Methylcellulose - administration & dosage ; Methylcellulose - analogs & derivatives ; Methylcellulose - pharmacokinetics ; Pharmacology. Drug treatments ; Physiological Phenomena ; Polymers - chemistry ; Solubility ; Solvents - chemistry ; Stomach - metabolism ; Tablets ; Technology, Pharmaceutical ; Temperature ; Time Factors ; Water - chemistry</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2008-11, Vol.48 (3), p.685-693</ispartof><rights>2008 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-79642b82e7018219f46e8f5e8fbfc431ba670385882023ca67796c87120968123</citedby><cites>FETCH-LOGICAL-c384t-79642b82e7018219f46e8f5e8fbfc431ba670385882023ca67796c87120968123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpba.2008.06.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21217893$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18715732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulinowski, Piotr</creatorcontrib><creatorcontrib>Dorożyński, Przemysław</creatorcontrib><creatorcontrib>Jachowicz, Renata</creatorcontrib><creatorcontrib>Węglarz, Władysław P.</creatorcontrib><title>An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms—A tool for quantitative assessment of hydrogel formation processes</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>Controlled release (CR) dosage forms are often based on polymeric matrices, e.g., sustained-release tablets and capsules. It is crucial to visualise and quantify processes of the hydrogel formation during the standard dissolution study. A method for imaging of CR, polymer-based dosage forms during dissolution study
in vitro is presented. Imaging was performed in a non-invasive way by means of the magnetic resonance imaging (MRI). This study was designed to simulate
in vivo conditions regarding temperature, volume, state and composition of dissolution media. Two formulations of hydrodynamically balanced systems (HBS) were chosen as model CR dosage forms. HBS release active substance in stomach while floating on the surface of the gastric content. Time evolutions of the diffusion region, hydrogel formation region and “dry core” region were obtained during a dissolution study of L-dopa as a model drug in two simulated gastric fluids (i.e. in fed and fasted state). This method seems to be a very promising tool for examining properties of new formulations of CR, polymer-based dosage forms or for comparison of generic and originator dosage forms before carrying out bioequivalence studies.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Capsules</subject><subject>Chemistry, Pharmaceutical</subject><subject>Computer Simulation</subject><subject>Controlled release dosage forms</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Diffusion</subject><subject>Dosage Forms</subject><subject>Drug Combinations</subject><subject>Equipment Design</subject><subject>Fasting - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Hydrodynamically balanced systems</subject><subject>Hydrogel formation</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypromellose Derivatives</subject><subject>Levodopa - administration & dosage</subject><subject>Levodopa - pharmacokinetics</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Methylcellulose - administration & dosage</subject><subject>Methylcellulose - analogs & derivatives</subject><subject>Methylcellulose - pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Physiological Phenomena</subject><subject>Polymers - chemistry</subject><subject>Solubility</subject><subject>Solvents - chemistry</subject><subject>Stomach - metabolism</subject><subject>Tablets</subject><subject>Technology, Pharmaceutical</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Water - chemistry</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuqFDEQhoMonvHoC7iQbHRlt7n0JQNuhoM3OOBGwV1Ip6vbDN3JnFT6wOx8CJ_IR_FJTM8MunMRQhVf_VX8PyHPOSs5482bfbk_dKYUjKmSNSUT9QOy4aqVhWiqbw_JhrWSFy1T9RV5grhnjNV8Wz0mVxnidSvFhvzaeep8gjGaBD3FIyaY6RAi7R1imJbkgqeYlt4BUuN7OpvRQ3KWRsDgjbdAXe45P9IwUBt8imGaslaECQzCa3oI03GGWHS56mkf0Iywrpjx94-fO5pCmE4b7xbjk0smuXugBhEQZ_Bplf1-7GMY4cTN5nTTIQYLK_SUPBrMhPDs8l-Tr-_ffbn5WNx-_vDpZndbWKmqVLTbphKdEtAyrgTfDlUDaqjz6wZbSd6ZpmVS1UoJJqTNVZ6w2SjBto3iQl6TV2fdvPluAUx6dmhhmoyHsKBuMlbLtsmgOIM2BsQIgz7EbFE8as70mpze6zU5vSanWaNzcnnoxUV96Wbo_41cosrAywtg0JppiNl6h385wQVv1VZm7u2Zg-zFvYOo0TrIMfUugk26D-5_d_wBeZO81A</recordid><startdate>20081104</startdate><enddate>20081104</enddate><creator>Kulinowski, Piotr</creator><creator>Dorożyński, Przemysław</creator><creator>Jachowicz, Renata</creator><creator>Węglarz, Władysław P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081104</creationdate><title>An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms—A tool for quantitative assessment of hydrogel formation processes</title><author>Kulinowski, Piotr ; Dorożyński, Przemysław ; Jachowicz, Renata ; Węglarz, Władysław P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-79642b82e7018219f46e8f5e8fbfc431ba670385882023ca67796c87120968123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Capsules</topic><topic>Chemistry, Pharmaceutical</topic><topic>Computer Simulation</topic><topic>Controlled release dosage forms</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Diffusion</topic><topic>Dosage Forms</topic><topic>Drug Combinations</topic><topic>Equipment Design</topic><topic>Fasting - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Hydrodynamically balanced systems</topic><topic>Hydrogel formation</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypromellose Derivatives</topic><topic>Levodopa - administration & dosage</topic><topic>Levodopa - pharmacokinetics</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Methylcellulose - administration & dosage</topic><topic>Methylcellulose - analogs & derivatives</topic><topic>Methylcellulose - pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Physiological Phenomena</topic><topic>Polymers - chemistry</topic><topic>Solubility</topic><topic>Solvents - chemistry</topic><topic>Stomach - metabolism</topic><topic>Tablets</topic><topic>Technology, Pharmaceutical</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kulinowski, Piotr</creatorcontrib><creatorcontrib>Dorożyński, Przemysław</creatorcontrib><creatorcontrib>Jachowicz, Renata</creatorcontrib><creatorcontrib>Węglarz, Władysław P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kulinowski, Piotr</au><au>Dorożyński, Przemysław</au><au>Jachowicz, Renata</au><au>Węglarz, Władysław P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms—A tool for quantitative assessment of hydrogel formation processes</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2008-11-04</date><risdate>2008</risdate><volume>48</volume><issue>3</issue><spage>685</spage><epage>693</epage><pages>685-693</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>Controlled release (CR) dosage forms are often based on polymeric matrices, e.g., sustained-release tablets and capsules. It is crucial to visualise and quantify processes of the hydrogel formation during the standard dissolution study. A method for imaging of CR, polymer-based dosage forms during dissolution study
in vitro is presented. Imaging was performed in a non-invasive way by means of the magnetic resonance imaging (MRI). This study was designed to simulate
in vivo conditions regarding temperature, volume, state and composition of dissolution media. Two formulations of hydrodynamically balanced systems (HBS) were chosen as model CR dosage forms. HBS release active substance in stomach while floating on the surface of the gastric content. Time evolutions of the diffusion region, hydrogel formation region and “dry core” region were obtained during a dissolution study of L-dopa as a model drug in two simulated gastric fluids (i.e. in fed and fasted state). This method seems to be a very promising tool for examining properties of new formulations of CR, polymer-based dosage forms or for comparison of generic and originator dosage forms before carrying out bioequivalence studies.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18715732</pmid><doi>10.1016/j.jpba.2008.06.025</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2008-11, Vol.48 (3), p.685-693 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Capsules Chemistry, Pharmaceutical Computer Simulation Controlled release dosage forms Delayed-Action Preparations - chemistry Diffusion Dosage Forms Drug Combinations Equipment Design Fasting - metabolism Fundamental and applied biological sciences. Psychology General pharmacology Hydrodynamically balanced systems Hydrogel formation Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogen-Ion Concentration Hypromellose Derivatives Levodopa - administration & dosage Levodopa - pharmacokinetics Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical sciences Methylcellulose - administration & dosage Methylcellulose - analogs & derivatives Methylcellulose - pharmacokinetics Pharmacology. Drug treatments Physiological Phenomena Polymers - chemistry Solubility Solvents - chemistry Stomach - metabolism Tablets Technology, Pharmaceutical Temperature Time Factors Water - chemistry |
| title | An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms—A tool for quantitative assessment of hydrogel formation processes |
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