Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea

Identification of common dietary substances capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. An antioxidant-rich polyphenolic fraction isolated from green tea (green tea polyphenols, GTPs) has been shown to possess anti-i...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1999-04, Vol.96 (8), p.4524-4529
Hauptverfasser: Haqqi, T.M, Anthony, D.D, Gupta, S, Ahmad, N, Lee, M.S, Kumar, G.K, Mukhtar, H
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container_title Proceedings of the National Academy of Sciences - PNAS
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creator Haqqi, T.M
Anthony, D.D
Gupta, S
Ahmad, N
Lee, M.S
Kumar, G.K
Mukhtar, H
description Identification of common dietary substances capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. An antioxidant-rich polyphenolic fraction isolated from green tea (green tea polyphenols, GTPs) has been shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of oral consumption of GTP on collagen-induced arthritis in mice. In three independent experiments mice given GTP in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice not given GTP in water (84% to 100%). The arthritis index also was significantly lower in GTP-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2, IFN-gamma, and tumor necrosis factor alpha in arthritic joints of GTP-fed mice. Histologic and immunohistochemical analysis of the arthritic joints in GTP-fed mice demonstrated only marginal joint infiltration by IFN-gamma and tumor necrosis factor alpha-producing cells as opposed to massive cellular infiltration and fully developed pannus in arthritic joints of non-GTP-fed mice. The neutral endopeptidase activity was approximately 7-fold higher in arthritic joints of non-GTP-fed mice in comparison to non-arthritic joints of unimmunized mice whereas it was only 2-fold higher in the arthritic joints of GTP-fed mice. Additionally, total IgG and type II collagen-specific IgG levels were lower in serum and arthritic joints of GTP-fed mice. Taken together our studies suggest that a polyphenolic fraction from green tea that is rich in antioxidants may be useful in the prevention of onset and severity of arthritis.
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subjects Animals
Antibodies
Antibody Formation
Arthritis
Arthritis, Experimental - immunology
Arthritis, Experimental - pathology
Arthritis, Experimental - prevention & control
Biological Sciences
Chickens
collagen
Collagen - immunology
cyclooxygenase 2
Cytokines
enzyme activity
Enzyme linked immunosorbent assay
Flavonoids
Green teas
Humans
immunoglobulin G
Immunoglobulin G - analysis
Immunoglobulin G - blood
Immunology
Inflammation
inhibition
Interferon-gamma - analysis
Interferon-gamma - genetics
interferons
Joint diseases
Joints
Joints - drug effects
Joints - immunology
Joints - pathology
knees
Male
medicinal properties
Mice
Mice, Inbred DBA
oral administration
oxygenases
Phenols - isolation & purification
Phenols - therapeutic use
Polymers - isolation & purification
Polymers - therapeutic use
Polyphenols
Potable water
Prevention
proteinases
Rodents
Tea
Tumor Necrosis Factor-alpha - analysis
Tumor Necrosis Factor-alpha - genetics
tumor necrosis factors
title Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea
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