Intra-articular penetration of ketoprofen and analgesic effects after topical patch application in rats

The purpose of this study was to evaluate percutaneous penetration and pharmacological effects of ketoprofen after transdermal administration, compared to the oral route. Skin and knee joint penetration of ketoprofen was tested by a microdialysis technique in rats and in vivo recovery was determined...

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Veröffentlicht in:	Journal of controlled release 2008-10, Vol.131 (2), p.107-112
Hauptverfasser:	Shinkai, Norihiro, Korenaga, Kazuko, Mizu, Hideo, Yamauchi, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Administration, Oral Analgesic effect Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - physiopathology Behavior, Animal - drug effects Biological and medical sciences Disease Models, Animal General pharmacology Ketoprofen - administration & dosage Ketoprofen - pharmacokinetics Ketoprofen - therapeutic use Ketoprofen patch Knee Joint - drug effects Knee Joint - metabolism Male Medical sciences Microdialysis Osteoarthritis, Knee - drug therapy Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - physiopathology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rat Rats Rats, Wistar Skin Absorption Tissue Distribution Transdermal penetration
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