Differential distribution of pyrokinin-isoforms in cerebral and abdominal neurohemal organs of the American cockroach
Different pyrokinin isoforms were identified from major neurohemal organs of the American cockroach. During their isolation they were recognized by bioassay using a hyperneural muscle preparation that is sensitive to pyrokinins. All structures were elucidated by sequence analysis and mass spectromet...
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| Veröffentlicht in: | Insect biochemistry and molecular biology 1999-02, Vol.29 (2), p.139-144 |
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| container_title | Insect biochemistry and molecular biology |
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| creator | Predel, R. Kellner, R. Nachman, R.J. Holman, G.M. Rapus, J. Gäde, G. |
| description | Different pyrokinin isoforms were identified from major neurohemal organs of the American cockroach. During their isolation they were recognized by bioassay using a hyperneural muscle preparation that is sensitive to pyrokinins. All structures were elucidated by sequence analysis and mass spectrometry. The primary structures of the novel peptides isolated from the retrocerebral complex are LVPFRPRL-NH
2 (designated Pea-PK-3) and DHLPHDVYSPRL-NH
2 (designated Pea-PK-4). A pyrokinin, labeled Pea-PK-5, was isolated from abdominal perisympathetic organs. Structural analysis of this peptide yielded the sequence GGGGSGETSGMWFGPRL-NH
2. The threshold concentrations of the identified pyrokinins for an eliciting effect on contractions of the hyperneural muscle preparations differed dramatically. This indicates that the different distribution of pyrokinin-isoform observed in neurohemal organs may be associated with different functions. This is the first report of a differential distribution of peptide-isoforms in the neurohemal organs of insects. |
| doi_str_mv | 10.1016/S0965-1748(98)00117-9 |
| format | Article |
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2 (designated Pea-PK-3) and DHLPHDVYSPRL-NH
2 (designated Pea-PK-4). A pyrokinin, labeled Pea-PK-5, was isolated from abdominal perisympathetic organs. Structural analysis of this peptide yielded the sequence GGGGSGETSGMWFGPRL-NH
2. The threshold concentrations of the identified pyrokinins for an eliciting effect on contractions of the hyperneural muscle preparations differed dramatically. This indicates that the different distribution of pyrokinin-isoform observed in neurohemal organs may be associated with different functions. This is the first report of a differential distribution of peptide-isoforms in the neurohemal organs of insects.</description><identifier>ISSN: 0965-1748</identifier><identifier>EISSN: 1879-0240</identifier><identifier>DOI: 10.1016/S0965-1748(98)00117-9</identifier><identifier>PMID: 10196736</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>amino acid sequences ; Animals ; Brain Chemistry ; central nervous system ; chemical structure ; fxprl amide peptides ; hormonal regulation ; Insect ; isolation ; muscle contraction ; Muscle, Smooth - physiology ; Myotropin ; Neurohemal organs ; Neuropeptide ; neuropeptides ; Neuropeptides - chemistry ; neurosecretory system ; Neurosecretory Systems - chemistry ; Peptide Mapping ; Periplaneta - chemistry ; Periplaneta americana ; perisympathetic organs ; Protein Isoforms ; purification ; Pyrokinins ; retrocerebral complex ; Visceral muscle</subject><ispartof>Insect biochemistry and molecular biology, 1999-02, Vol.29 (2), p.139-144</ispartof><rights>1999 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-d3f6af9c3bc02d3948f0b9c630792e615c4427b5dd0b49072d66752bef92eb323</citedby><cites>FETCH-LOGICAL-c482t-d3f6af9c3bc02d3948f0b9c630792e615c4427b5dd0b49072d66752bef92eb323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0965174898001179$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10196736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Predel, R.</creatorcontrib><creatorcontrib>Kellner, R.</creatorcontrib><creatorcontrib>Nachman, R.J.</creatorcontrib><creatorcontrib>Holman, G.M.</creatorcontrib><creatorcontrib>Rapus, J.</creatorcontrib><creatorcontrib>Gäde, G.</creatorcontrib><title>Differential distribution of pyrokinin-isoforms in cerebral and abdominal neurohemal organs of the American cockroach</title><title>Insect biochemistry and molecular biology</title><addtitle>Insect Biochem Mol Biol</addtitle><description>Different pyrokinin isoforms were identified from major neurohemal organs of the American cockroach. During their isolation they were recognized by bioassay using a hyperneural muscle preparation that is sensitive to pyrokinins. All structures were elucidated by sequence analysis and mass spectrometry. The primary structures of the novel peptides isolated from the retrocerebral complex are LVPFRPRL-NH
2 (designated Pea-PK-3) and DHLPHDVYSPRL-NH
2 (designated Pea-PK-4). A pyrokinin, labeled Pea-PK-5, was isolated from abdominal perisympathetic organs. Structural analysis of this peptide yielded the sequence GGGGSGETSGMWFGPRL-NH
2. The threshold concentrations of the identified pyrokinins for an eliciting effect on contractions of the hyperneural muscle preparations differed dramatically. This indicates that the different distribution of pyrokinin-isoform observed in neurohemal organs may be associated with different functions. This is the first report of a differential distribution of peptide-isoforms in the neurohemal organs of insects.</description><subject>amino acid sequences</subject><subject>Animals</subject><subject>Brain Chemistry</subject><subject>central nervous system</subject><subject>chemical structure</subject><subject>fxprl amide peptides</subject><subject>hormonal regulation</subject><subject>Insect</subject><subject>isolation</subject><subject>muscle contraction</subject><subject>Muscle, Smooth - physiology</subject><subject>Myotropin</subject><subject>Neurohemal organs</subject><subject>Neuropeptide</subject><subject>neuropeptides</subject><subject>Neuropeptides - chemistry</subject><subject>neurosecretory system</subject><subject>Neurosecretory Systems - chemistry</subject><subject>Peptide Mapping</subject><subject>Periplaneta - chemistry</subject><subject>Periplaneta americana</subject><subject>perisympathetic organs</subject><subject>Protein Isoforms</subject><subject>purification</subject><subject>Pyrokinins</subject><subject>retrocerebral complex</subject><subject>Visceral muscle</subject><issn>0965-1748</issn><issn>1879-0240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS1ERYfCTwCyQrBIuX7EjleoKq9KlViUri0_O6YTe7ATpP77epoKsevKtvydc6_OQegNhlMMmH-6AsmHHgs2fpDjRwCMRS-foQ0eheyBMHiONv-QY_Sy1t8AwNggXqDj5iC5oHyDli8xBF98mqPedS7WuUSzzDGnLoduf1fybUwx9bHmkMtUu5g623hTGq6T67RxeYqpvZJfSt76qV1zudGpHhzmre_OJl-i1U2Y7W3J2m5foaOgd9W_fjxP0PW3r7_Of_SXP79fnJ9d9paNZO4dDVwHaamxQByVbAxgpOUUhCSe48EyRoQZnAPDJAjiOBcDMT60b0MJPUHvV999yX8WX2c1xWr9bqeTz0tVXPKRDiCeBLEgI2WYNnBYQVtyrcUHtS9x0uVOYVCHYtRDMeqQupKjeihGyaZ7-zhgMZN3_6nWJhrwbgWCzkrflFjV9RUBTIFITDkciM8r4Vtif6Mvqtrok_UuFm9n5XJ8Yol7MfCoaw</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Predel, R.</creator><creator>Kellner, R.</creator><creator>Nachman, R.J.</creator><creator>Holman, G.M.</creator><creator>Rapus, J.</creator><creator>Gäde, G.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>Differential distribution of pyrokinin-isoforms in cerebral and abdominal neurohemal organs of the American cockroach</title><author>Predel, R. ; Kellner, R. ; Nachman, R.J. ; Holman, G.M. ; Rapus, J. ; Gäde, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-d3f6af9c3bc02d3948f0b9c630792e615c4427b5dd0b49072d66752bef92eb323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>amino acid sequences</topic><topic>Animals</topic><topic>Brain Chemistry</topic><topic>central nervous system</topic><topic>chemical structure</topic><topic>fxprl amide peptides</topic><topic>hormonal regulation</topic><topic>Insect</topic><topic>isolation</topic><topic>muscle contraction</topic><topic>Muscle, Smooth - physiology</topic><topic>Myotropin</topic><topic>Neurohemal organs</topic><topic>Neuropeptide</topic><topic>neuropeptides</topic><topic>Neuropeptides - chemistry</topic><topic>neurosecretory system</topic><topic>Neurosecretory Systems - chemistry</topic><topic>Peptide Mapping</topic><topic>Periplaneta - chemistry</topic><topic>Periplaneta americana</topic><topic>perisympathetic organs</topic><topic>Protein Isoforms</topic><topic>purification</topic><topic>Pyrokinins</topic><topic>retrocerebral complex</topic><topic>Visceral muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Predel, R.</creatorcontrib><creatorcontrib>Kellner, R.</creatorcontrib><creatorcontrib>Nachman, R.J.</creatorcontrib><creatorcontrib>Holman, G.M.</creatorcontrib><creatorcontrib>Rapus, J.</creatorcontrib><creatorcontrib>Gäde, G.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Insect biochemistry and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Predel, R.</au><au>Kellner, R.</au><au>Nachman, R.J.</au><au>Holman, G.M.</au><au>Rapus, J.</au><au>Gäde, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential distribution of pyrokinin-isoforms in cerebral and abdominal neurohemal organs of the American cockroach</atitle><jtitle>Insect biochemistry and molecular biology</jtitle><addtitle>Insect Biochem Mol Biol</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>29</volume><issue>2</issue><spage>139</spage><epage>144</epage><pages>139-144</pages><issn>0965-1748</issn><eissn>1879-0240</eissn><abstract>Different pyrokinin isoforms were identified from major neurohemal organs of the American cockroach. During their isolation they were recognized by bioassay using a hyperneural muscle preparation that is sensitive to pyrokinins. All structures were elucidated by sequence analysis and mass spectrometry. The primary structures of the novel peptides isolated from the retrocerebral complex are LVPFRPRL-NH
2 (designated Pea-PK-3) and DHLPHDVYSPRL-NH
2 (designated Pea-PK-4). A pyrokinin, labeled Pea-PK-5, was isolated from abdominal perisympathetic organs. Structural analysis of this peptide yielded the sequence GGGGSGETSGMWFGPRL-NH
2. The threshold concentrations of the identified pyrokinins for an eliciting effect on contractions of the hyperneural muscle preparations differed dramatically. This indicates that the different distribution of pyrokinin-isoform observed in neurohemal organs may be associated with different functions. This is the first report of a differential distribution of peptide-isoforms in the neurohemal organs of insects.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>10196736</pmid><doi>10.1016/S0965-1748(98)00117-9</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | amino acid sequences Animals Brain Chemistry central nervous system chemical structure fxprl amide peptides hormonal regulation Insect isolation muscle contraction Muscle, Smooth - physiology Myotropin Neurohemal organs Neuropeptide neuropeptides Neuropeptides - chemistry neurosecretory system Neurosecretory Systems - chemistry Peptide Mapping Periplaneta - chemistry Periplaneta americana perisympathetic organs Protein Isoforms purification Pyrokinins retrocerebral complex Visceral muscle |
| title | Differential distribution of pyrokinin-isoforms in cerebral and abdominal neurohemal organs of the American cockroach |
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