Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations
Abstract Study Objective To determine the effect of dexmedetomidine on intraoperative bleeding during septoplasty and tympanoplasty operations. Design Randomized, placebo-controlled study. Setting Univesity medical center. Patients 80 ASA physical status I and II patients, aged 18 to 65 years, 40 of...
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| Veröffentlicht in: | Journal of clinical anesthesia 2008-09, Vol.20 (6), p.437-441 |
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| creator | Ayoglu, Hilal, MD Yapakci, Osman, MD Ugur, Mehmet Birol, MD Uzun, Lokman, MD Altunkaya, Hanife, MD Ozer, Yetkin, MD Uyanik, Rahsan, MD Cinar, Fikret, MD Ozkocak, Isil, MD |
| description | Abstract Study Objective To determine the effect of dexmedetomidine on intraoperative bleeding during septoplasty and tympanoplasty operations. Design Randomized, placebo-controlled study. Setting Univesity medical center. Patients 80 ASA physical status I and II patients, aged 18 to 65 years, 40 of whom were scheduled for septoplasty and 40 to undergo tympanoplasty operations. Interventions Patients undergoing septoplasty (S) and tympanoplasty (T) operations were randomly divided into 4 groups. Dexmedetomidine (D) was administered to Group SD and Group TD first as a bolus dose of one μ g kg−1 , then intraoperative maintenance was supplied with dexmedetomidine 0.7 μ g kg−1 hour−1 . Groups S and T (controls) were given identical amounts of saline. If systolic blood pressure measurements are greater than 20% preoperative values, then fentanyl one μ g kg−1 was given. Measurements Intraoperative blood loss was determined with suction volumes and gauze counting. Bleeding was rated according to a 6-point scale. Hemodynamic parameters and fentanyl administration were recorded. Main Results Group SD had less bleeding and lower bleeding scores ( P < 0.05). In addition, this group received less intraoperative fentanyl ( P < 0.05). The only significant difference between Groups TD and T was the amount of intraoperative fentanyl given (35.4 ± 58.8 vs 110.0 ± 81.0 μ g) ( P < 0.05). Conclusion Dexmedetomidine reduces bleeding, bleeding scores, and intraoperative fentanyl consumption during general anesthesia in septoplasty operations. |
| doi_str_mv | 10.1016/j.jclinane.2008.04.008 |
| format | Article |
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Design Randomized, placebo-controlled study. Setting Univesity medical center. Patients 80 ASA physical status I and II patients, aged 18 to 65 years, 40 of whom were scheduled for septoplasty and 40 to undergo tympanoplasty operations. Interventions Patients undergoing septoplasty (S) and tympanoplasty (T) operations were randomly divided into 4 groups. Dexmedetomidine (D) was administered to Group SD and Group TD first as a bolus dose of one μ g kg−1 , then intraoperative maintenance was supplied with dexmedetomidine 0.7 μ g kg−1 hour−1 . Groups S and T (controls) were given identical amounts of saline. If systolic blood pressure measurements are greater than 20% preoperative values, then fentanyl one μ g kg−1 was given. Measurements Intraoperative blood loss was determined with suction volumes and gauze counting. Bleeding was rated according to a 6-point scale. Hemodynamic parameters and fentanyl administration were recorded. Main Results Group SD had less bleeding and lower bleeding scores ( P < 0.05). In addition, this group received less intraoperative fentanyl ( P < 0.05). The only significant difference between Groups TD and T was the amount of intraoperative fentanyl given (35.4 ± 58.8 vs 110.0 ± 81.0 μ g) ( P < 0.05). Conclusion Dexmedetomidine reduces bleeding, bleeding scores, and intraoperative fentanyl consumption during general anesthesia in septoplasty operations.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/j.jclinane.2008.04.008</identifier><identifier>PMID: 18929284</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adrenergic alpha-Agonists - pharmacology ; Adult ; Aged ; Analgesics ; Analgesics, Opioid - therapeutic use ; Anesthesia ; Anesthesia & Perioperative Care ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Loss, Surgical - prevention & control ; Blood Pressure - drug effects ; Cardiovascular disease ; Controlled hypotension ; Dexmedetomidine ; Dexmedetomidine - pharmacology ; Double-Blind Method ; Drug dosages ; Evacuations & rescues ; Female ; Fentanyl - therapeutic use ; Hematocrit ; Humans ; Male ; Medical sciences ; Middle Aged ; Nasal Septum - surgery ; Pain Medicine ; Surgery ; Surgery: Otorhinolaryngology ; Tympanoplasty</subject><ispartof>Journal of clinical anesthesia, 2008-09, Vol.20 (6), p.437-441</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-f82c4dd9d3bfccc4dc4cba59695b8481805db4c82da7d25edaa261a79c8b6cdd3</citedby><cites>FETCH-LOGICAL-c479t-f82c4dd9d3bfccc4dc4cba59695b8481805db4c82da7d25edaa261a79c8b6cdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1034980323?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20774848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18929284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ayoglu, Hilal, MD</creatorcontrib><creatorcontrib>Yapakci, Osman, MD</creatorcontrib><creatorcontrib>Ugur, Mehmet Birol, MD</creatorcontrib><creatorcontrib>Uzun, Lokman, MD</creatorcontrib><creatorcontrib>Altunkaya, Hanife, MD</creatorcontrib><creatorcontrib>Ozer, Yetkin, MD</creatorcontrib><creatorcontrib>Uyanik, Rahsan, MD</creatorcontrib><creatorcontrib>Cinar, Fikret, MD</creatorcontrib><creatorcontrib>Ozkocak, Isil, MD</creatorcontrib><title>Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations</title><title>Journal of clinical anesthesia</title><addtitle>J Clin Anesth</addtitle><description>Abstract Study Objective To determine the effect of dexmedetomidine on intraoperative bleeding during septoplasty and tympanoplasty operations. Design Randomized, placebo-controlled study. Setting Univesity medical center. Patients 80 ASA physical status I and II patients, aged 18 to 65 years, 40 of whom were scheduled for septoplasty and 40 to undergo tympanoplasty operations. Interventions Patients undergoing septoplasty (S) and tympanoplasty (T) operations were randomly divided into 4 groups. Dexmedetomidine (D) was administered to Group SD and Group TD first as a bolus dose of one μ g kg−1 , then intraoperative maintenance was supplied with dexmedetomidine 0.7 μ g kg−1 hour−1 . Groups S and T (controls) were given identical amounts of saline. If systolic blood pressure measurements are greater than 20% preoperative values, then fentanyl one μ g kg−1 was given. Measurements Intraoperative blood loss was determined with suction volumes and gauze counting. Bleeding was rated according to a 6-point scale. Hemodynamic parameters and fentanyl administration were recorded. Main Results Group SD had less bleeding and lower bleeding scores ( P < 0.05). In addition, this group received less intraoperative fentanyl ( P < 0.05). The only significant difference between Groups TD and T was the amount of intraoperative fentanyl given (35.4 ± 58.8 vs 110.0 ± 81.0 μ g) ( P < 0.05). Conclusion Dexmedetomidine reduces bleeding, bleeding scores, and intraoperative fentanyl consumption during general anesthesia in septoplasty operations.</description><subject>Adolescent</subject><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Adult</subject><subject>Aged</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Anesthesia</subject><subject>Anesthesia & Perioperative Care</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Loss, Surgical - prevention & control</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular disease</subject><subject>Controlled hypotension</subject><subject>Dexmedetomidine</subject><subject>Dexmedetomidine - pharmacology</subject><subject>Double-Blind Method</subject><subject>Drug dosages</subject><subject>Evacuations & rescues</subject><subject>Female</subject><subject>Fentanyl - therapeutic use</subject><subject>Hematocrit</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nasal Septum - surgery</subject><subject>Pain Medicine</subject><subject>Surgery</subject><subject>Surgery: Otorhinolaryngology</subject><subject>Tympanoplasty</subject><issn>0952-8180</issn><issn>1873-4529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFklFr1TAUx4Mo7jr9CqMg-tZrkqZt8iKOsakw8EF9DmlyKqltUpN2eL_9Trl3DvYiBM4h-eXknP8_hFwwumeUNR-G_WBHH0yAPadU7qnYY3hGdky2VSlqrp6THVU1LyWT9Iy8ynmglOIBe0nOmFRccSl2BK77Huzi7yBAzkXsCwd_J3CwxMk7H6DwoUjgVuvDr6IbAdyWuDVtIcO8xHk0eTkUJrhiOUyzCQ87cYZkFh9Dfk1e9GbM8OYUz8nPm-sfV1_K22-fv15d3pZWtGope8mtcE65quutxdQK25laNarupNgGqV0nrOTOtI7X4IzhDTOtsrJrrHPVOXl_rDun-GeFvOjJZwvjiDrFNetGNbJiLUPw7RNwiGsK2JtmtBJK0opXSDVHyqaYc4Jez8lPJh0Q0psNetAPNujNBk2FxoAXL07l1w7FfLx20h2BdyfAZGvGPplgff7Hcdq2AidG7tORA1TtzkPS2XoIFl1IaJt20f-_l49PSmyUx1d_wwHy49w6c0319-3TbFJTXEyJqroHTJ_BYQ</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Ayoglu, Hilal, MD</creator><creator>Yapakci, Osman, MD</creator><creator>Ugur, Mehmet Birol, MD</creator><creator>Uzun, Lokman, MD</creator><creator>Altunkaya, Hanife, MD</creator><creator>Ozer, Yetkin, MD</creator><creator>Uyanik, Rahsan, MD</creator><creator>Cinar, Fikret, MD</creator><creator>Ozkocak, Isil, MD</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations</title><author>Ayoglu, Hilal, MD ; Yapakci, Osman, MD ; Ugur, Mehmet Birol, MD ; Uzun, Lokman, MD ; Altunkaya, Hanife, MD ; Ozer, Yetkin, MD ; Uyanik, Rahsan, MD ; Cinar, Fikret, MD ; Ozkocak, Isil, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-f82c4dd9d3bfccc4dc4cba59695b8481805db4c82da7d25edaa261a79c8b6cdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Adult</topic><topic>Aged</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Anesthesia</topic><topic>Anesthesia & Perioperative Care</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Loss, Surgical - prevention & control</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular disease</topic><topic>Controlled hypotension</topic><topic>Dexmedetomidine</topic><topic>Dexmedetomidine - pharmacology</topic><topic>Double-Blind Method</topic><topic>Drug dosages</topic><topic>Evacuations & rescues</topic><topic>Female</topic><topic>Fentanyl - therapeutic use</topic><topic>Hematocrit</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nasal Septum - surgery</topic><topic>Pain Medicine</topic><topic>Surgery</topic><topic>Surgery: Otorhinolaryngology</topic><topic>Tympanoplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayoglu, Hilal, MD</creatorcontrib><creatorcontrib>Yapakci, Osman, MD</creatorcontrib><creatorcontrib>Ugur, Mehmet Birol, MD</creatorcontrib><creatorcontrib>Uzun, Lokman, MD</creatorcontrib><creatorcontrib>Altunkaya, Hanife, MD</creatorcontrib><creatorcontrib>Ozer, Yetkin, MD</creatorcontrib><creatorcontrib>Uyanik, Rahsan, MD</creatorcontrib><creatorcontrib>Cinar, Fikret, MD</creatorcontrib><creatorcontrib>Ozkocak, Isil, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayoglu, Hilal, MD</au><au>Yapakci, Osman, MD</au><au>Ugur, Mehmet Birol, MD</au><au>Uzun, Lokman, MD</au><au>Altunkaya, Hanife, MD</au><au>Ozer, Yetkin, MD</au><au>Uyanik, Rahsan, MD</au><au>Cinar, Fikret, MD</au><au>Ozkocak, Isil, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations</atitle><jtitle>Journal of clinical anesthesia</jtitle><addtitle>J Clin Anesth</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>20</volume><issue>6</issue><spage>437</spage><epage>441</epage><pages>437-441</pages><issn>0952-8180</issn><eissn>1873-4529</eissn><abstract>Abstract Study Objective To determine the effect of dexmedetomidine on intraoperative bleeding during septoplasty and tympanoplasty operations. Design Randomized, placebo-controlled study. Setting Univesity medical center. Patients 80 ASA physical status I and II patients, aged 18 to 65 years, 40 of whom were scheduled for septoplasty and 40 to undergo tympanoplasty operations. Interventions Patients undergoing septoplasty (S) and tympanoplasty (T) operations were randomly divided into 4 groups. Dexmedetomidine (D) was administered to Group SD and Group TD first as a bolus dose of one μ g kg−1 , then intraoperative maintenance was supplied with dexmedetomidine 0.7 μ g kg−1 hour−1 . Groups S and T (controls) were given identical amounts of saline. If systolic blood pressure measurements are greater than 20% preoperative values, then fentanyl one μ g kg−1 was given. Measurements Intraoperative blood loss was determined with suction volumes and gauze counting. Bleeding was rated according to a 6-point scale. Hemodynamic parameters and fentanyl administration were recorded. Main Results Group SD had less bleeding and lower bleeding scores ( P < 0.05). In addition, this group received less intraoperative fentanyl ( P < 0.05). The only significant difference between Groups TD and T was the amount of intraoperative fentanyl given (35.4 ± 58.8 vs 110.0 ± 81.0 μ g) ( P < 0.05). Conclusion Dexmedetomidine reduces bleeding, bleeding scores, and intraoperative fentanyl consumption during general anesthesia in septoplasty operations.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18929284</pmid><doi>10.1016/j.jclinane.2008.04.008</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adrenergic alpha-Agonists - pharmacology Adult Aged Analgesics Analgesics, Opioid - therapeutic use Anesthesia Anesthesia & Perioperative Care Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Loss, Surgical - prevention & control Blood Pressure - drug effects Cardiovascular disease Controlled hypotension Dexmedetomidine Dexmedetomidine - pharmacology Double-Blind Method Drug dosages Evacuations & rescues Female Fentanyl - therapeutic use Hematocrit Humans Male Medical sciences Middle Aged Nasal Septum - surgery Pain Medicine Surgery Surgery: Otorhinolaryngology Tympanoplasty |
| title | Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations |
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