The Gain-of-Function Chinese Hamster Ovary Mutant LEC11B Expresses One of Two Chinese Hamster FUT6 Genes Due to the Loss of a Negative Regulatory Factor

The LEC11 Chinese hamster ovary (CHO) gain-of-function mutant expresses an α(1,3)fucosyltransferase (α(1,3)Fuc-T) activity that generates the Le X , sialyl-Le X , and VIM-2 glycan determinants and has been extensively used for studies of E-selectin ligand specificity. In order to identify regulato...

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Veröffentlicht in:	The Journal of biological chemistry 1999-04, Vol.274 (15), p.10439-10450
Hauptverfasser:	Zhang, A, Potvin, B, Zaiman, A, Chen, W, Kumar, R, Phillips, L, Stanley, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Blotting, Northern CHO Cells Cricetinae Fucosyltransferases - biosynthesis Fucosyltransferases - genetics Humans Molecular Sequence Data Polymerase Chain Reaction Restriction Mapping Transfection
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