Synthesis and in Vitro Pharmacology of a Series of New Chiral Histamine H3-Receptor Ligands:  2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl Ether Derivatives

To investigate stereospecificity and the mechanism of activation of the histamine H3-receptor, a series of 2-(R and S)-amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives were synthesized. In these compounds, the structures of the well-known antagonist iodoproxyfan and the full agonists R- or S-(α...

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