Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries
Abstract Background Absorbable metallic stents (AMS) composed of magnesium alloy were designed to complete degradation within 90–120 days. Among the potential advantages of these stents, when compared to conventional stents, are the elimination of late stent thrombosis, chronic inflammation, and art...
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| Veröffentlicht in: | Cardiovascular revascularization medicine 2008-10, Vol.9 (4), p.248-254 |
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| creator | Slottow, Tina L. Pinto Pakala, Rajbabu Okabe, Teruo Hellinga, David Lovec, Rachel J Tio, Fermin O Bui, Anh B Waksman, Ron |
| description | Abstract Background Absorbable metallic stents (AMS) composed of magnesium alloy were designed to complete degradation within 90–120 days. Among the potential advantages of these stents, when compared to conventional stents, are the elimination of late stent thrombosis, chronic inflammation, and artifacts during noninvasive imaging. Methods Magnesium-based AMS were deployed in juvenile domestic pig coronary arteries. Angiography, optical coherence tomography (OCT), and intravascular ultrasound (IVUS) were performed before and after implant and then at 28 days and 3 months following stenting. The animals were sacrificed at 28 days or 3 months following stent implantation. Stented vessels were harvested and analyzed by histomorphometry. Results Over time, OCT, IVUS, and histologic images revealed a progressive degradation of the stents. Mean stent strut width in the OCT images after implantation was 0.24±0.032 mm, then decreased to 0.12±0.007 mm ( P |
| doi_str_mv | 10.1016/j.carrev.2008.04.001 |
| format | Article |
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Pinto ; Pakala, Rajbabu ; Okabe, Teruo ; Hellinga, David ; Lovec, Rachel J ; Tio, Fermin O ; Bui, Anh B ; Waksman, Ron</creator><creatorcontrib>Slottow, Tina L. Pinto ; Pakala, Rajbabu ; Okabe, Teruo ; Hellinga, David ; Lovec, Rachel J ; Tio, Fermin O ; Bui, Anh B ; Waksman, Ron</creatorcontrib><description>Abstract Background Absorbable metallic stents (AMS) composed of magnesium alloy were designed to complete degradation within 90–120 days. Among the potential advantages of these stents, when compared to conventional stents, are the elimination of late stent thrombosis, chronic inflammation, and artifacts during noninvasive imaging. Methods Magnesium-based AMS were deployed in juvenile domestic pig coronary arteries. Angiography, optical coherence tomography (OCT), and intravascular ultrasound (IVUS) were performed before and after implant and then at 28 days and 3 months following stenting. The animals were sacrificed at 28 days or 3 months following stent implantation. Stented vessels were harvested and analyzed by histomorphometry. Results Over time, OCT, IVUS, and histologic images revealed a progressive degradation of the stents. Mean stent strut width in the OCT images after implantation was 0.24±0.032 mm, then decreased to 0.12±0.007 mm ( P <.0001) at 28 days and to 0.151±0.032 mm at 3 months ( P <.0001 vs. implant, P =.078 vs. 28 days). Conclusion Magnesium-based AMS degrade over a 3-month time period in a porcine model. Its structure is not apparent by angiography but is well-visualized by OCT and IVUS. OCT allowed quantitative assessment of stent degradation.</description><identifier>ISSN: 1553-8389</identifier><identifier>EISSN: 1878-0938</identifier><identifier>DOI: 10.1016/j.carrev.2008.04.001</identifier><identifier>PMID: 18928950</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Absorbable Implants ; Alloys ; Angioplasty, Balloon, Coronary - instrumentation ; Animals ; Bioabsorbable stent ; Cardiovascular ; Coronary Angiography ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - pathology ; Intravascular ultrasound ; Magnesium ; Materials Testing ; Models, Animal ; Optical coherence tomography ; Prosthesis Design ; Stents ; Sus scrofa ; Time Factors ; Tomography, Optical Coherence ; Ultrasonography, Interventional</subject><ispartof>Cardiovascular revascularization medicine, 2008-10, Vol.9 (4), p.248-254</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-f0ea5a22a241a5e7e64cf55cddcb714854ef111e06a73b556fbc4c71442b18133</citedby><cites>FETCH-LOGICAL-c481t-f0ea5a22a241a5e7e64cf55cddcb714854ef111e06a73b556fbc4c71442b18133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1553838908001309$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18928950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slottow, Tina L. Pinto</creatorcontrib><creatorcontrib>Pakala, Rajbabu</creatorcontrib><creatorcontrib>Okabe, Teruo</creatorcontrib><creatorcontrib>Hellinga, David</creatorcontrib><creatorcontrib>Lovec, Rachel J</creatorcontrib><creatorcontrib>Tio, Fermin O</creatorcontrib><creatorcontrib>Bui, Anh B</creatorcontrib><creatorcontrib>Waksman, Ron</creatorcontrib><title>Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries</title><title>Cardiovascular revascularization medicine</title><addtitle>Cardiovasc Revasc Med</addtitle><description>Abstract Background Absorbable metallic stents (AMS) composed of magnesium alloy were designed to complete degradation within 90–120 days. Among the potential advantages of these stents, when compared to conventional stents, are the elimination of late stent thrombosis, chronic inflammation, and artifacts during noninvasive imaging. Methods Magnesium-based AMS were deployed in juvenile domestic pig coronary arteries. Angiography, optical coherence tomography (OCT), and intravascular ultrasound (IVUS) were performed before and after implant and then at 28 days and 3 months following stenting. The animals were sacrificed at 28 days or 3 months following stent implantation. Stented vessels were harvested and analyzed by histomorphometry. Results Over time, OCT, IVUS, and histologic images revealed a progressive degradation of the stents. Mean stent strut width in the OCT images after implantation was 0.24±0.032 mm, then decreased to 0.12±0.007 mm ( P <.0001) at 28 days and to 0.151±0.032 mm at 3 months ( P <.0001 vs. implant, P =.078 vs. 28 days). Conclusion Magnesium-based AMS degrade over a 3-month time period in a porcine model. Its structure is not apparent by angiography but is well-visualized by OCT and IVUS. OCT allowed quantitative assessment of stent degradation.</description><subject>Absorbable Implants</subject><subject>Alloys</subject><subject>Angioplasty, Balloon, Coronary - instrumentation</subject><subject>Animals</subject><subject>Bioabsorbable stent</subject><subject>Cardiovascular</subject><subject>Coronary Angiography</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - pathology</subject><subject>Intravascular ultrasound</subject><subject>Magnesium</subject><subject>Materials Testing</subject><subject>Models, Animal</subject><subject>Optical coherence tomography</subject><subject>Prosthesis Design</subject><subject>Stents</subject><subject>Sus scrofa</subject><subject>Time Factors</subject><subject>Tomography, Optical Coherence</subject><subject>Ultrasonography, Interventional</subject><issn>1553-8389</issn><issn>1878-0938</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsuO1DAQjBCIXRb-ACGfuCXYiZ14LkhoxWOllfYAnK2O05n1kNih7Yw038BP42hGQuKyJz-6qlrdVUXxVvBKcNF-OFQWiPBY1ZzrisuKc_GsuBa60yXfNfp5vivVlLrRu6viVYwHzpuubruXxZXQu1rvFL8u_jwsyVmYmA2PSOgtshTmsCdYHk8M_MCcTwRHiHadgNg65VcM61aYYe_8noWR9S5AHwP10E_I8r_H6NaZxYQ-sQGz3ADJBZ_V2BLIOo-5IwUPlLtQQnIYXxcvRpgivrmcN8XPL59_3H4r7x--3t1-ui-t1CKVI0dQUNdQSwEKO2ylHZWyw2D7TkitJI5CCOQtdE2vVDv2VtpckXUvtGiam-L9WXeh8HvFmMzsosVpAo9hjabdtVpkeAbKM9BSiJFwNAvlqelkBDebCeZgziaYzQTDpckmZNq7i_7azzj8I122ngEfzwDMUx4dkonWbbsfHKFNZgjuqQ7_C9jJ-c3HX3jCeAgr-bxBI0ysDTfftyBsOeB6Y-d0_AVihbOn</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Slottow, Tina L. Pinto</creator><creator>Pakala, Rajbabu</creator><creator>Okabe, Teruo</creator><creator>Hellinga, David</creator><creator>Lovec, Rachel J</creator><creator>Tio, Fermin O</creator><creator>Bui, Anh B</creator><creator>Waksman, Ron</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries</title><author>Slottow, Tina L. Pinto ; Pakala, Rajbabu ; Okabe, Teruo ; Hellinga, David ; Lovec, Rachel J ; Tio, Fermin O ; Bui, Anh B ; Waksman, Ron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-f0ea5a22a241a5e7e64cf55cddcb714854ef111e06a73b556fbc4c71442b18133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Absorbable Implants</topic><topic>Alloys</topic><topic>Angioplasty, Balloon, Coronary - instrumentation</topic><topic>Animals</topic><topic>Bioabsorbable stent</topic><topic>Cardiovascular</topic><topic>Coronary Angiography</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - pathology</topic><topic>Intravascular ultrasound</topic><topic>Magnesium</topic><topic>Materials Testing</topic><topic>Models, Animal</topic><topic>Optical coherence tomography</topic><topic>Prosthesis Design</topic><topic>Stents</topic><topic>Sus scrofa</topic><topic>Time Factors</topic><topic>Tomography, Optical Coherence</topic><topic>Ultrasonography, Interventional</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slottow, Tina L. Pinto</creatorcontrib><creatorcontrib>Pakala, Rajbabu</creatorcontrib><creatorcontrib>Okabe, Teruo</creatorcontrib><creatorcontrib>Hellinga, David</creatorcontrib><creatorcontrib>Lovec, Rachel J</creatorcontrib><creatorcontrib>Tio, Fermin O</creatorcontrib><creatorcontrib>Bui, Anh B</creatorcontrib><creatorcontrib>Waksman, Ron</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular revascularization medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slottow, Tina L. Pinto</au><au>Pakala, Rajbabu</au><au>Okabe, Teruo</au><au>Hellinga, David</au><au>Lovec, Rachel J</au><au>Tio, Fermin O</au><au>Bui, Anh B</au><au>Waksman, Ron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries</atitle><jtitle>Cardiovascular revascularization medicine</jtitle><addtitle>Cardiovasc Revasc Med</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>9</volume><issue>4</issue><spage>248</spage><epage>254</epage><pages>248-254</pages><issn>1553-8389</issn><eissn>1878-0938</eissn><abstract>Abstract Background Absorbable metallic stents (AMS) composed of magnesium alloy were designed to complete degradation within 90–120 days. Among the potential advantages of these stents, when compared to conventional stents, are the elimination of late stent thrombosis, chronic inflammation, and artifacts during noninvasive imaging. Methods Magnesium-based AMS were deployed in juvenile domestic pig coronary arteries. Angiography, optical coherence tomography (OCT), and intravascular ultrasound (IVUS) were performed before and after implant and then at 28 days and 3 months following stenting. The animals were sacrificed at 28 days or 3 months following stent implantation. Stented vessels were harvested and analyzed by histomorphometry. Results Over time, OCT, IVUS, and histologic images revealed a progressive degradation of the stents. Mean stent strut width in the OCT images after implantation was 0.24±0.032 mm, then decreased to 0.12±0.007 mm ( P <.0001) at 28 days and to 0.151±0.032 mm at 3 months ( P <.0001 vs. implant, P =.078 vs. 28 days). Conclusion Magnesium-based AMS degrade over a 3-month time period in a porcine model. Its structure is not apparent by angiography but is well-visualized by OCT and IVUS. OCT allowed quantitative assessment of stent degradation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18928950</pmid><doi>10.1016/j.carrev.2008.04.001</doi><tpages>7</tpages></addata></record> |
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| subjects | Absorbable Implants Alloys Angioplasty, Balloon, Coronary - instrumentation Animals Bioabsorbable stent Cardiovascular Coronary Angiography Coronary Vessels - diagnostic imaging Coronary Vessels - pathology Intravascular ultrasound Magnesium Materials Testing Models, Animal Optical coherence tomography Prosthesis Design Stents Sus scrofa Time Factors Tomography, Optical Coherence Ultrasonography, Interventional |
| title | Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries |
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