Inhibition of the Na+ /Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3

Background Long QT syndrome (LQTS) is associated with sudden cardiac death resulting from torsades de pointes (TdP), which are triggered by early afterdepolarizations (EADs). The cardiac Na+ /Ca2+ exchanger (NCX) has been suggested to work as a trigger for EADs. Objective The purpose of this study w...

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Veröffentlicht in:	Heart rhythm 2008-10, Vol.5 (10), p.1444-1452
Hauptverfasser:	Milberg, Peter, MD, Pott, Christian, MD, Fink, Martin, PhD, Frommeyer, Gerrit, MS, Matsuda, Toshio, PhD, Baba, Akemichi, PhD, Osada, Nani, PhD, Breithardt, Günter, MD, FESC, FACC, FHRS, Noble, Denis, PhD, CBE, FRS, FRCP (Hon), Eckardt, Lars, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - pharmacology Animals Cardiovascular Disease Models, Animal Female Long QT Syndrome - classification Long QT Syndrome - prevention & control Muscle Cells - drug effects Phenyl Ethers - pharmacology Rabbits Sodium-Calcium Exchanger - metabolism Torsades de Pointes - prevention & control
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