1-Arylnaphthalene Lignan: A Novel Scaffold for Type 5 Phosphodiesterase Inhibitor

1-Arylnaphthalene lignan, which had been reported as a PDE4 inhibitor by Iwasaki, was disclosed as a new structural class of PDE5 inhibitors. The structural requirements for potent and specific PDE5 inhibition were revealed in a 1-arylnaphthalene lignan series, in which 1-(3-bromo-4,5-dimethoxypheny...

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Veröffentlicht in:	Journal of medicinal chemistry 1999-04, Vol.42 (7), p.1293-1305
Hauptverfasser:	Ukita, Tatsuzo, Nakamura, Yoshinori, Kubo, Akira, Yamamoto, Yasuo, Takahashi, Masami, Kotera, Jun, Ikeo, Tomohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-GMP Phosphodiesterases Animals Aorta - drug effects Biological and medical sciences Cardiovascular Agents - chemical synthesis Cardiovascular Agents - chemistry Cardiovascular Agents - pharmacology Cardiovascular system Coronary Vessels - drug effects Cyclic Nucleotide Phosphodiesterases, Type 5 Dogs Heart - drug effects In Vitro Techniques Isoenzymes - antagonists & inhibitors Lignans - chemistry Medical sciences Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Myocardium - enzymology Naphthalenes - chemical synthesis Naphthalenes - chemistry Naphthalenes - pharmacology Pharmacology. Drug treatments Phosphodiesterase Inhibitors - chemical synthesis Phosphodiesterase Inhibitors - chemistry Phosphodiesterase Inhibitors - pharmacology Phosphoric Diester Hydrolases - metabolism Piperazines - chemical synthesis Piperazines - chemistry Piperazines - pharmacology Rats Structure-Activity Relationship Swine Vasodilator agents. Cerebral vasodilators
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