Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1

The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for embryonic development in mammals. Mutations in the human JAGGED1 (JAG1) gene, which encodes a ligand for the Notch family of transmembrane receptors, cause the autosomal dominant disorder Alagi...

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Veröffentlicht in:	Human molecular genetics 1999-05, Vol.8 (5), p.723-730
Hauptverfasser:	Xue, Yingzi, Gao, Xiang, Lindsell, Claire E., Norton, Christine R., Chang, Bo, Hicks, Carol, Gendron-Maguire, Maureen, Rand, Elizabeth B., Weinmaster, Gerry, Gridley, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Vessels - physiopathology Calcium-Binding Proteins Chromosome Mapping Embryo, Mammalian - physiopathology Embryonic and Fetal Development - genetics Female Fetal Death - genetics Gene Deletion Heterozygote Homozygote Intercellular Signaling Peptides and Proteins Jagged-1 Protein Male Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Mutant Strains Mutation Phenotype Platelet Endothelial Cell Adhesion Molecule-1 - immunology Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Proteins - genetics Proteins - metabolism Receptors, Notch Serrate-Jagged Proteins
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