Trypanosoma cruzi: Orchiectomy and dehydroepiandrosterone therapy in infected rats

The ability of gonadal hormones to influence and induce diverse immunological functions during the course of a number of parasitic infections has been extensively studied in the latest decades. Dehydroepiandrosterone and its sulfate are the most abundant steroid hormones secreted by the human adrena...

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Veröffentlicht in:	Experimental parasitology 2008-11, Vol.120 (3), p.249-254
Hauptverfasser:	Filipin, Marina Del Vecchio, Brazão, Vânia, Caetano, Leony Cristina, Santello, Fabricia Helena, Toldo, Míriam Paula Alonso, Caetano, Luana Naiara, do Prado, José Clóvis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Animals Biological and medical sciences Cell Count Chagas Disease - drug therapy Chagas Disease - immunology Chagas Disease - surgery Dehydroepiandrosterone (DHEA) Dehydroepiandrosterone - pharmacology Dehydroepiandrosterone - therapeutic use Fundamental and applied biological sciences. Psychology Heart - parasitology Histopathology Interferon gamma (IFN-γ) Interferon-gamma - blood Life cycle. Host-agent relationship. Pathogenesis Macrophages, Peritoneal - cytology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Male Myocardium - pathology Nitric oxide (NO) Nitric Oxide - biosynthesis Orchiectomy Parasitemia - immunology Parasitemia - parasitology Protozoa Rats Rats, Wistar Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - immunology
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