Knockdown of Snail, a novel zinc finger transcription factor, via RNA interference increases A549 cell sensitivity to cisplatin via JNK/mitochondrial pathway

Summary Previous reports have implicated epithelial-mesenchymal transition (EMT) as a major cause of cancer. Snail, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether Snail could...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2008-10, Vol.62 (1), p.8-14
Hauptverfasser:	Zhuo, Wenlei, Wang, Yan, Zhuo, Xianlu, Zhang, Yunsong, Ao, Xujun, Chen, Zhengtang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Blotting, Western Cell Line, Tumor Cell Survival Cisplatin Cisplatin - pharmacology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Epithelial-mesenchymal transition Hematology, Oncology and Palliative Medicine Humans In Situ Nick-End Labeling JNK Lung Neoplasms - drug therapy Lung Neoplasms - metabolism MAP Kinase Kinase 4 - metabolism Medical sciences Mitochondria - metabolism Mitochondrial pathway Non-small-cell lung cancer Pneumology Pulmonary/Respiratory Reverse Transcriptase Polymerase Chain Reaction RNA Interference Sensitivity Signal Transduction - physiology Snail Snail Family Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism Tumors Tumors of the respiratory system and mediastinum
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