Apoptosis induction by E2F-1 via adenoviral-mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines

E2F-1, a transcription factor by discovery, is thought to play a crucial role in regulating G1/S cell cycle progression. Its activity is modulated by complex formation with the retinoblastoma protein and related proteins. Overexpression of E2F-1 has been shown to induce apoptosis in quiescent fibrob...

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Veröffentlicht in:	Cancer gene therapy 1999-03, Vol.6 (2), p.163-172
Hauptverfasser:	Liu, T J, Wang, M, Breau, R L, Henderson, Y, El-Naggar, A K, Steck, K D, Sicard, M W, Clayman, G L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferase Adenoviridae - genetics Adenoviruses Animals Apoptosis Biotin Blotting, Western Cancer Carcinoma, Squamous Cell - therapy Carrier Proteins Cell Cycle Cell Cycle Proteins Cell Division - drug effects Chloramphenicol Chloramphenicol O-acetyltransferase Chloramphenicol O-Acetyltransferase - metabolism DNA Fragmentation DNA nucleotidylexotransferase DNA-Binding Proteins E2F protein E2F Transcription Factors E2F-1 protein E2F1 protein E2F1 Transcription Factor Fibroblasts Gene transfer Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - therapy Humans In Situ Nick-End Labeling Mice Mice, Nude Neoplasms, Experimental - pathology p53 Protein Proteins Retina Retinoblastoma Retinoblastoma protein Retinoblastoma-Binding Protein 1 Squamous cell carcinoma Time Factors Transcription Factor DP1 Transcription Factors - genetics Transcription Factors - pharmacology Tumor cell lines Tumor Cells, Cultured Tumors
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