A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex

Nuclear receptors play critical roles in the regulation of eukaryotic gene expression. We report the isolation and functional characterization of a novel transcriptional coactivator, termed steroid receptor RNA activator (SRA). SRA is selective for steroid hormone receptors and mediates transactivat...

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Veröffentlicht in:	Cell 1999-04, Vol.97 (1), p.17-27
Hauptverfasser:	Lanz, Rainer B, McKenna, Neil J, Onate, Sergio A, Albrecht, Urs, Wong, Jiemin, Tsai, Sophia Y, Tsai, Ming-Jer, O’Malley, Bert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence DNA, Complementary - isolation & purification Histone Acetyltransferases Humans Macromolecular Substances Mice Molecular Sequence Data Multiprotein Complexes Nuclear Receptor Coactivator 1 Receptors, Cytoplasmic and Nuclear - physiology Receptors, Steroid - genetics Receptors, Steroid - physiology RNA - physiology Sequence Homology, Nucleic Acid Trans-Activators - genetics Trans-Activators - physiology Transcription Factors - chemistry Transcription Factors - physiology
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