C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown that subcutaneous adipose tissue secretes interleukin-6 in vivo. In this study we have sought associations of level...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1999-04, Vol.19 (4), p.972-978 |
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| creator | Yudkin, John S Stehouwer, C.D.A Emeis, J.J Coppack, S.W |
| description | C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown that subcutaneous adipose tissue secretes interleukin-6 in vivo. In this study we have sought associations of levels of C-reactive protein and interleukin-6 with measures of obesity and of chronic infection as their putative determinants. We have also related levels of C-reactive protein and interleukin-6 to markers of the insulin resistance syndrome and of endothelial dysfunction. We performed a cross-sectional study in 107 nondiabetic subjects(1) Levels of C-reactive protein, and concentrations of the proinflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, were related to all measures of obesity, but titers of antibodies to Helicobacter pylori were only weakly and those of Chlamydia pneumoniae and cytomegalovirus were not significantly correlated with levels of these molecules. Levels of C-reactive protein were significantly related to those of interleukin-6 (r=0.37, P |
| doi_str_mv | 10.1161/01.ATV.19.4.972 |
| format | Article |
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We have shown that subcutaneous adipose tissue secretes interleukin-6 in vivo. In this study we have sought associations of levels of C-reactive protein and interleukin-6 with measures of obesity and of chronic infection as their putative determinants. We have also related levels of C-reactive protein and interleukin-6 to markers of the insulin resistance syndrome and of endothelial dysfunction. We performed a cross-sectional study in 107 nondiabetic subjects(1) Levels of C-reactive protein, and concentrations of the proinflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, were related to all measures of obesity, but titers of antibodies to Helicobacter pylori were only weakly and those of Chlamydia pneumoniae and cytomegalovirus were not significantly correlated with levels of these molecules. Levels of C-reactive protein were significantly related to those of interleukin-6 (r=0.37, P<0.0005) and tumor necrosis factor-alpha (r=0.46, P<0.0001). (2) Concentrations of C-reactive protein were related to insulin resistance as calculated from the homoeostasis model assessment model, blood pressure, HDL, and triglyceride, and to markers of endothelial dysfunction (plasma levels of von Willebrand factor, tissue plasminogen activator, and cellular fibronectin). A mean standard deviation score of levels of acute phase markers correlated closely with a similar score of insulin resistance syndrome variables (r=0.59, P<0.00005), this relationship being weakened only marginally by removing measures of obesity from the insulin resistance score (r=0.53, P<0.00005). These data suggest that adipose tissue is an important determinant of a low level, chronic inflammatory state as reflected by levels of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein, and that infection with H pylori, C pneumoniae, and cytomegalovirus is not. Moreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease. (Arterioscler Thromb Vasc Biol. 1999;19:972-978.)</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/01.ATV.19.4.972</identifier><identifier>PMID: 10195925</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adipose Tissue - metabolism ; Adipose Tissue - physiology ; Adult ; Aged ; Biological and medical sciences ; Body fat ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Coronary heart disease ; Cytokines - physiology ; Endothelium, Vascular - physiopathology ; Female ; Follow-Up Studies ; Heart ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Male ; Medical sciences ; Middle Aged ; Obesity - blood ; Obesity - epidemiology ; Obesity - physiopathology ; Random Allocation ; United Kingdom - epidemiology</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 1999-04, Vol.19 (4), p.972-978</ispartof><rights>1999 American Heart Association, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Apr 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2962-dfbf850b11b46d7a11802c22eefd79377f98e7b7ea6ce03ba08059e81ca31163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1753426$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10195925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yudkin, John S</creatorcontrib><creatorcontrib>Stehouwer, C.D.A</creatorcontrib><creatorcontrib>Emeis, J.J</creatorcontrib><creatorcontrib>Coppack, S.W</creatorcontrib><title>C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown that subcutaneous adipose tissue secretes interleukin-6 in vivo. In this study we have sought associations of levels of C-reactive protein and interleukin-6 with measures of obesity and of chronic infection as their putative determinants. We have also related levels of C-reactive protein and interleukin-6 to markers of the insulin resistance syndrome and of endothelial dysfunction. We performed a cross-sectional study in 107 nondiabetic subjects(1) Levels of C-reactive protein, and concentrations of the proinflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, were related to all measures of obesity, but titers of antibodies to Helicobacter pylori were only weakly and those of Chlamydia pneumoniae and cytomegalovirus were not significantly correlated with levels of these molecules. Levels of C-reactive protein were significantly related to those of interleukin-6 (r=0.37, P<0.0005) and tumor necrosis factor-alpha (r=0.46, P<0.0001). (2) Concentrations of C-reactive protein were related to insulin resistance as calculated from the homoeostasis model assessment model, blood pressure, HDL, and triglyceride, and to markers of endothelial dysfunction (plasma levels of von Willebrand factor, tissue plasminogen activator, and cellular fibronectin). A mean standard deviation score of levels of acute phase markers correlated closely with a similar score of insulin resistance syndrome variables (r=0.59, P<0.00005), this relationship being weakened only marginally by removing measures of obesity from the insulin resistance score (r=0.53, P<0.00005). These data suggest that adipose tissue is an important determinant of a low level, chronic inflammatory state as reflected by levels of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein, and that infection with H pylori, C pneumoniae, and cytomegalovirus is not. Moreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease. (Arterioscler Thromb Vasc Biol. 1999;19:972-978.)</description><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue - physiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Cytokines - physiology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Obesity - epidemiology</subject><subject>Obesity - physiopathology</subject><subject>Random Allocation</subject><subject>United Kingdom - epidemiology</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkk1vEzEQhlcIREvgzA1ZCHHqprbX--FeUBRaWqlSqhDB0fJ6Zxu3Gzt4vFT5XfxBHBIJhOSvkZ-Z8czrLHvL6JSxip1TNp2tvk2ZnIqprPmz7JSVXOSiKqrn6UxrmZeV4CfZK8QHSqngnL7MThhlspS8PM1-zfMlaBPtTyB3wUewjqRxDXqI6x35OrYPYCJekBmiN1ZH6x2S7zauyaIFtHF3Rm4cjkNyWiYbo3YGzoh2Hbl0nY9rGKweyOcd9qMze_cUi9ylTC7uL5Z-ANL7QOa76B-tAySLYO-tS6ncPbkKfkNmnd16BLKyiCN8ep296PWA8Oa4T7LV1eVqfp3fLr7czGe3ueGy4nnXt31T0paxVlRdrRlrKDecA_RdLYu67mUDdVuDrgzQotW0oaWEhhldpOYWk-zjIew2-B8jYFQbiwaGQTvwI6pKVnXDOE_g-__ABz8Gl56mOBUFZSytk-z8AJngEQP0ahvsRoedYlTttVSUqaSlYlIJlbRMHu-OYcd2A90__EG8BHw4AhqNHvqQWm_xL1eXheD7OsQBe_JDhICPw_gEQa3_SKz2n6KoaJkzKSUVyczTTFX9Bu_2uGU</recordid><startdate>199904</startdate><enddate>199904</enddate><creator>Yudkin, John S</creator><creator>Stehouwer, C.D.A</creator><creator>Emeis, J.J</creator><creator>Coppack, S.W</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199904</creationdate><title>C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?</title><author>Yudkin, John S ; Stehouwer, C.D.A ; Emeis, J.J ; Coppack, S.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2962-dfbf850b11b46d7a11802c22eefd79377f98e7b7ea6ce03ba08059e81ca31163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue - physiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Cytokines - physiology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Obesity - epidemiology</topic><topic>Obesity - physiopathology</topic><topic>Random Allocation</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yudkin, John S</creatorcontrib><creatorcontrib>Stehouwer, C.D.A</creatorcontrib><creatorcontrib>Emeis, J.J</creatorcontrib><creatorcontrib>Coppack, S.W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yudkin, John S</au><au>Stehouwer, C.D.A</au><au>Emeis, J.J</au><au>Coppack, S.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>1999-04</date><risdate>1999</risdate><volume>19</volume><issue>4</issue><spage>972</spage><epage>978</epage><pages>972-978</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown that subcutaneous adipose tissue secretes interleukin-6 in vivo. In this study we have sought associations of levels of C-reactive protein and interleukin-6 with measures of obesity and of chronic infection as their putative determinants. We have also related levels of C-reactive protein and interleukin-6 to markers of the insulin resistance syndrome and of endothelial dysfunction. We performed a cross-sectional study in 107 nondiabetic subjects(1) Levels of C-reactive protein, and concentrations of the proinflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, were related to all measures of obesity, but titers of antibodies to Helicobacter pylori were only weakly and those of Chlamydia pneumoniae and cytomegalovirus were not significantly correlated with levels of these molecules. Levels of C-reactive protein were significantly related to those of interleukin-6 (r=0.37, P<0.0005) and tumor necrosis factor-alpha (r=0.46, P<0.0001). (2) Concentrations of C-reactive protein were related to insulin resistance as calculated from the homoeostasis model assessment model, blood pressure, HDL, and triglyceride, and to markers of endothelial dysfunction (plasma levels of von Willebrand factor, tissue plasminogen activator, and cellular fibronectin). A mean standard deviation score of levels of acute phase markers correlated closely with a similar score of insulin resistance syndrome variables (r=0.59, P<0.00005), this relationship being weakened only marginally by removing measures of obesity from the insulin resistance score (r=0.53, P<0.00005). These data suggest that adipose tissue is an important determinant of a low level, chronic inflammatory state as reflected by levels of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein, and that infection with H pylori, C pneumoniae, and cytomegalovirus is not. Moreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease. (Arterioscler Thromb Vasc Biol. 1999;19:972-978.)</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>10195925</pmid><doi>10.1161/01.ATV.19.4.972</doi><tpages>7</tpages></addata></record> |
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| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 1999-04, Vol.19 (4), p.972-978 |
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| subjects | Adipose Tissue - metabolism Adipose Tissue - physiology Adult Aged Biological and medical sciences Body fat C-Reactive Protein - metabolism Cardiology. Vascular system Coronary heart disease Cytokines - physiology Endothelium, Vascular - physiopathology Female Follow-Up Studies Heart Humans Insulin resistance Insulin Resistance - physiology Male Medical sciences Middle Aged Obesity - blood Obesity - epidemiology Obesity - physiopathology Random Allocation United Kingdom - epidemiology |
| title | C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue? |
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