Viruses and Bacteria in Bronchial Samples from Patients with Primary Hypogammaglobulinemia
Viruses and bacteria in bronchoalveolar lavage fluids, protected specimen brush samples, and bronchial biopsies from 14 patients with primary hypogammaglobulinemia (11 patients with common variable immunodeficiency [CVID] and three patients with X-linked agammaglobulinemia [XLA]) were analyzed. At t...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 1999-04, Vol.159 (4), p.1199-1204 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | KAINULAINEN, LEENA NIKOSKELAINEN, JUKKA VUORINEN, TYTTI TEVOLA, KALLE LIIPPO, KARI RUUSKANEN, OLLI |
| description | Viruses and bacteria in bronchoalveolar lavage fluids, protected specimen brush samples, and bronchial biopsies from 14 patients with primary hypogammaglobulinemia (11 patients with common variable immunodeficiency [CVID] and three patients with X-linked agammaglobulinemia [XLA]) were analyzed. At the time of the study, the patients had no signs of acute respiratory infections, and no antibiotics were administered. In addition to routine bacterial and viral cultures, polymerase chain reaction tests were used for the detection of adenovirus, cytomegalovirus (CMV), herpes simplex virus 1, enterovirus, rhinovirus, Borrelia burgdorferi, Chlamydia pneumoniae, Legionella spp., Mycoplasma pneumoniae, Pneumocystis carinii, and Ureaplasma urealyticum. Viruses (four adenoviruses, one CMV, and one rhinovirus) were detected in four of the 11 (36%) CVID patients. No viruses were found in the three patients with XLA or in 13 control patients. Bacteria from the lower respiratory tract were detected in nine of the 14 (64%) patients with hypogammaglobulinemia and three of the 13 (23%) control patients. Haemophilus influenzae was the most prevalent bacterium (43%) in the hypogammaglobulinemia patients. The study shows that patients with CVID harbor viral and bacterial infections in the lower respiratory tract, which may predispose to the development of changes in the respiratory tract. |
| doi_str_mv | 10.1164/ajrccm.159.4.9807067 |
| format | Article |
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At the time of the study, the patients had no signs of acute respiratory infections, and no antibiotics were administered. In addition to routine bacterial and viral cultures, polymerase chain reaction tests were used for the detection of adenovirus, cytomegalovirus (CMV), herpes simplex virus 1, enterovirus, rhinovirus, Borrelia burgdorferi, Chlamydia pneumoniae, Legionella spp., Mycoplasma pneumoniae, Pneumocystis carinii, and Ureaplasma urealyticum. Viruses (four adenoviruses, one CMV, and one rhinovirus) were detected in four of the 11 (36%) CVID patients. No viruses were found in the three patients with XLA or in 13 control patients. Bacteria from the lower respiratory tract were detected in nine of the 14 (64%) patients with hypogammaglobulinemia and three of the 13 (23%) control patients. Haemophilus influenzae was the most prevalent bacterium (43%) in the hypogammaglobulinemia patients. The study shows that patients with CVID harbor viral and bacterial infections in the lower respiratory tract, which may predispose to the development of changes in the respiratory tract.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/ajrccm.159.4.9807067</identifier><identifier>PMID: 10194166</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Adolescent ; Adult ; Agammaglobulinemia - genetics ; Agammaglobulinemia - microbiology ; Agammaglobulinemia - virology ; Aged ; AIDS/HIV ; Bacteria - isolation & purification ; Biological and medical sciences ; Bronchi - microbiology ; Bronchi - virology ; Bronchoalveolar Lavage Fluid - microbiology ; Bronchoalveolar Lavage Fluid - virology ; Child ; Common Variable Immunodeficiency - microbiology ; Common Variable Immunodeficiency - virology ; Female ; Genetic Linkage ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Male ; Medical sciences ; Middle Aged ; Polymerase Chain Reaction ; Viruses - isolation & purification ; X Chromosome</subject><ispartof>American journal of respiratory and critical care medicine, 1999-04, Vol.159 (4), p.1199-1204</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-6f312bdd247f8c95f09f49dda59eb9f7439918698724266e00e3b4c844b3b9573</citedby><cites>FETCH-LOGICAL-c367t-6f312bdd247f8c95f09f49dda59eb9f7439918698724266e00e3b4c844b3b9573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,4027,4028,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1751711$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10194166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAINULAINEN, LEENA</creatorcontrib><creatorcontrib>NIKOSKELAINEN, JUKKA</creatorcontrib><creatorcontrib>VUORINEN, TYTTI</creatorcontrib><creatorcontrib>TEVOLA, KALLE</creatorcontrib><creatorcontrib>LIIPPO, KARI</creatorcontrib><creatorcontrib>RUUSKANEN, OLLI</creatorcontrib><title>Viruses and Bacteria in Bronchial Samples from Patients with Primary Hypogammaglobulinemia</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Viruses and bacteria in bronchoalveolar lavage fluids, protected specimen brush samples, and bronchial biopsies from 14 patients with primary hypogammaglobulinemia (11 patients with common variable immunodeficiency [CVID] and three patients with X-linked agammaglobulinemia [XLA]) were analyzed. At the time of the study, the patients had no signs of acute respiratory infections, and no antibiotics were administered. In addition to routine bacterial and viral cultures, polymerase chain reaction tests were used for the detection of adenovirus, cytomegalovirus (CMV), herpes simplex virus 1, enterovirus, rhinovirus, Borrelia burgdorferi, Chlamydia pneumoniae, Legionella spp., Mycoplasma pneumoniae, Pneumocystis carinii, and Ureaplasma urealyticum. Viruses (four adenoviruses, one CMV, and one rhinovirus) were detected in four of the 11 (36%) CVID patients. No viruses were found in the three patients with XLA or in 13 control patients. Bacteria from the lower respiratory tract were detected in nine of the 14 (64%) patients with hypogammaglobulinemia and three of the 13 (23%) control patients. Haemophilus influenzae was the most prevalent bacterium (43%) in the hypogammaglobulinemia patients. The study shows that patients with CVID harbor viral and bacterial infections in the lower respiratory tract, which may predispose to the development of changes in the respiratory tract.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Agammaglobulinemia - genetics</subject><subject>Agammaglobulinemia - microbiology</subject><subject>Agammaglobulinemia - virology</subject><subject>Aged</subject><subject>AIDS/HIV</subject><subject>Bacteria - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Bronchi - microbiology</subject><subject>Bronchi - virology</subject><subject>Bronchoalveolar Lavage Fluid - microbiology</subject><subject>Bronchoalveolar Lavage Fluid - virology</subject><subject>Child</subject><subject>Common Variable Immunodeficiency - microbiology</subject><subject>Common Variable Immunodeficiency - virology</subject><subject>Female</subject><subject>Genetic Linkage</subject><subject>Humans</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Viruses - isolation & purification</subject><subject>X Chromosome</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1q3TAQRkVpadK0b1CKFqWLgG81lixZyyY0TSHQQH8o3YixLN2rINk3kk3I29fBhnY1szjfN8Mh5C2wHYAUH_EuW5t20Oid2OmWKSbVM3IKDW8qoRV7vuxM8UoI_fuEvCrljjGoW2AvyQkw0AKkPCV_foU8F1coDj29QDu5HJCGgV7kcbCHgJF-x3SMC-HzmOgtTsENU6EPYTrQ2xwS5kd6_Xgc95gS7uPYzTEMLgV8TV54jMW92eYZ-Xn1-cfldXXz7cvXy083leVSTZX0HOqu72uhfGt145n2Qvc9Ntp12ivBtYZW6lbVopbSMeZ4J2wrRMc73Sh-Rj6svcc83s-uTCaFYl2MOLhxLkZqqZRWT6BYQZvHUrLz5rj-b4CZJ6dmdWoWp0aYzekSe7f1z11y_X-hVeICvN8ALBajzzjYUP5xqgEFsGDnK3YI-8NDyM6UhDEurbAdXu8CaM3_Aocfj8Q</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>KAINULAINEN, LEENA</creator><creator>NIKOSKELAINEN, JUKKA</creator><creator>VUORINEN, TYTTI</creator><creator>TEVOLA, KALLE</creator><creator>LIIPPO, KARI</creator><creator>RUUSKANEN, OLLI</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Viruses and Bacteria in Bronchial Samples from Patients with Primary Hypogammaglobulinemia</title><author>KAINULAINEN, LEENA ; NIKOSKELAINEN, JUKKA ; VUORINEN, TYTTI ; TEVOLA, KALLE ; LIIPPO, KARI ; RUUSKANEN, OLLI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-6f312bdd247f8c95f09f49dda59eb9f7439918698724266e00e3b4c844b3b9573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Agammaglobulinemia - genetics</topic><topic>Agammaglobulinemia - microbiology</topic><topic>Agammaglobulinemia - virology</topic><topic>Aged</topic><topic>AIDS/HIV</topic><topic>Bacteria - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Bronchi - microbiology</topic><topic>Bronchi - virology</topic><topic>Bronchoalveolar Lavage Fluid - microbiology</topic><topic>Bronchoalveolar Lavage Fluid - virology</topic><topic>Child</topic><topic>Common Variable Immunodeficiency - microbiology</topic><topic>Common Variable Immunodeficiency - virology</topic><topic>Female</topic><topic>Genetic Linkage</topic><topic>Humans</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Viruses - isolation & purification</topic><topic>X Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAINULAINEN, LEENA</creatorcontrib><creatorcontrib>NIKOSKELAINEN, JUKKA</creatorcontrib><creatorcontrib>VUORINEN, TYTTI</creatorcontrib><creatorcontrib>TEVOLA, KALLE</creatorcontrib><creatorcontrib>LIIPPO, KARI</creatorcontrib><creatorcontrib>RUUSKANEN, OLLI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAINULAINEN, LEENA</au><au>NIKOSKELAINEN, JUKKA</au><au>VUORINEN, TYTTI</au><au>TEVOLA, KALLE</au><au>LIIPPO, KARI</au><au>RUUSKANEN, OLLI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Viruses and Bacteria in Bronchial Samples from Patients with Primary Hypogammaglobulinemia</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>159</volume><issue>4</issue><spage>1199</spage><epage>1204</epage><pages>1199-1204</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Viruses and bacteria in bronchoalveolar lavage fluids, protected specimen brush samples, and bronchial biopsies from 14 patients with primary hypogammaglobulinemia (11 patients with common variable immunodeficiency [CVID] and three patients with X-linked agammaglobulinemia [XLA]) were analyzed. At the time of the study, the patients had no signs of acute respiratory infections, and no antibiotics were administered. In addition to routine bacterial and viral cultures, polymerase chain reaction tests were used for the detection of adenovirus, cytomegalovirus (CMV), herpes simplex virus 1, enterovirus, rhinovirus, Borrelia burgdorferi, Chlamydia pneumoniae, Legionella spp., Mycoplasma pneumoniae, Pneumocystis carinii, and Ureaplasma urealyticum. Viruses (four adenoviruses, one CMV, and one rhinovirus) were detected in four of the 11 (36%) CVID patients. No viruses were found in the three patients with XLA or in 13 control patients. Bacteria from the lower respiratory tract were detected in nine of the 14 (64%) patients with hypogammaglobulinemia and three of the 13 (23%) control patients. Haemophilus influenzae was the most prevalent bacterium (43%) in the hypogammaglobulinemia patients. The study shows that patients with CVID harbor viral and bacterial infections in the lower respiratory tract, which may predispose to the development of changes in the respiratory tract.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>10194166</pmid><doi>10.1164/ajrccm.159.4.9807067</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of respiratory and critical care medicine, 1999-04, Vol.159 (4), p.1199-1204 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload; American Thoracic Society (ATS) Journals Online |
| subjects | Adolescent Adult Agammaglobulinemia - genetics Agammaglobulinemia - microbiology Agammaglobulinemia - virology Aged AIDS/HIV Bacteria - isolation & purification Biological and medical sciences Bronchi - microbiology Bronchi - virology Bronchoalveolar Lavage Fluid - microbiology Bronchoalveolar Lavage Fluid - virology Child Common Variable Immunodeficiency - microbiology Common Variable Immunodeficiency - virology Female Genetic Linkage Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Male Medical sciences Middle Aged Polymerase Chain Reaction Viruses - isolation & purification X Chromosome |
| title | Viruses and Bacteria in Bronchial Samples from Patients with Primary Hypogammaglobulinemia |
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