Effects of different adjuvants on rotavirus antibody responses and protection in mice following intramuscular immunization with inactivated rotavirus
I.m. immunization of mice with inactivated rotavirus particles protects against subsequent infection. To optimize protection, the effects of different adjuvants (QS-21, QS-7, QUIL A, PCPP and RAS) with potential for human use were compared. Twenty-eight days after i.m. immunization with 20 μg of pur...
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| Veröffentlicht in: | Vaccine 1999-03, Vol.17 (11), p.1573-1580 |
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| creator | McNeal, Monica M Rae, Mary N Ward, Richard L |
| description | I.m. immunization of mice with inactivated rotavirus particles protects against subsequent infection. To optimize protection, the effects of different adjuvants (QS-21, QS-7, QUIL A, PCPP and RAS) with potential for human use were compared. Twenty-eight days after i.m. immunization with 20 μg of purified, UV/psoralen-inactivated murine rotavirus (EDIM), either with or without adjuvant, BALB/c mice were orally challenged with live EDIM and virus shedding was measured. All five adjuvants stimulated large (
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| doi_str_mv | 10.1016/S0264-410X(98)00359-4 |
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P<0.001) increases in rotavirus antibody, but significant differences were found between adjuvants. The order of rotavirus IgG responses, i.e. no adjuvant<RAS<QS-7<Quil A<QS-21<PCPP, was the same as the order of protection except that QS-21 and PCPP were reversed. These results establish the importance of adjuvants during i.m. immunization with rotavirus and identify those with the greatest potential.]]></description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(98)00359-4</identifier><identifier>PMID: 10195795</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants ; Adjuvants, Immunologic ; Animals ; Antibodies, Viral - biosynthesis ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Injections, Intramuscular ; Intramuscular immunization ; Mice ; Mice, Inbred BALB C ; Microbiology ; Rotavirus ; Rotavirus - immunology ; Rotavirus Infections - prevention & control ; Saponins - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Inactivated - administration & dosage ; Vaccines, Inactivated - immunology ; Viral Vaccines - administration & dosage ; Viral Vaccines - immunology ; Virology</subject><ispartof>Vaccine, 1999-03, Vol.17 (11), p.1573-1580</ispartof><rights>1999 Elsevier Science Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-87dbcb64fe12ee32990c9863546b074511fd6143e9200f12257c202fd43567693</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0264-410X(98)00359-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1742684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10195795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McNeal, Monica M</creatorcontrib><creatorcontrib>Rae, Mary N</creatorcontrib><creatorcontrib>Ward, Richard L</creatorcontrib><title>Effects of different adjuvants on rotavirus antibody responses and protection in mice following intramuscular immunization with inactivated rotavirus</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description><![CDATA[I.m. immunization of mice with inactivated rotavirus particles protects against subsequent infection. To optimize protection, the effects of different adjuvants (QS-21, QS-7, QUIL A, PCPP and RAS) with potential for human use were compared. Twenty-eight days after i.m. immunization with 20 μg of purified, UV/psoralen-inactivated murine rotavirus (EDIM), either with or without adjuvant, BALB/c mice were orally challenged with live EDIM and virus shedding was measured. All five adjuvants stimulated large (
P<0.001) increases in rotavirus antibody, but significant differences were found between adjuvants. The order of rotavirus IgG responses, i.e. no adjuvant<RAS<QS-7<Quil A<QS-21<PCPP, was the same as the order of protection except that QS-21 and PCPP were reversed. These results establish the importance of adjuvants during i.m. immunization with rotavirus and identify those with the greatest potential.]]></description><subject>Adjuvants</subject><subject>Adjuvants, Immunologic</subject><subject>Animals</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intramuscular</subject><subject>Intramuscular immunization</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Rotavirus</subject><subject>Rotavirus - immunology</subject><subject>Rotavirus Infections - prevention & control</subject><subject>Saponins - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, Inactivated - administration & dosage</subject><subject>Vaccines, Inactivated - immunology</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - immunology</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uFSEYxYnR2Gv1ETQsjNHFKDD8GVbGNG01aeJCTdwRBj6UZoa5wsxt6nv4vjL33lh3XUEOv3M-4CD0nJK3lFD57gthkjecku-vdfeGkFbohj9AG9qptmGCdg_R5h9ygp6Uck0IES3Vj9FJTdBCabFBf85DADcXPAXsY91nSDO2_nrZ2bTKCedptruYl4KrEvvJ3-IMZTulAqvk8bYSNSNWNiY8Rgc4TMMw3cT0oypztuNS3DLYjOM4Lin-tnv4Js4_67mt1p2dwd9NeooeBTsUeHZcT9G3i_OvZx-bq8-Xn84-XDWOMzo3nfK96yUPQBlAy7QmTneyFVz2RHFBafCS8hY0IyRQxoRyjLDgeSukkro9Ra8OufUJvxYosxljcTAMNsG0FCO1VEqQ7l6QKka5UCsoDqDLUykZgtnmONp8aygxa3FmX5xZWzG6M_viDK--F8cBSz-C_891aKoCL4-ALc4OIdvkYrnjFGeyW3PeHzCo37aLkE1xEZIDH3PtyPgp3nOTv7zhuLw</recordid><startdate>19990317</startdate><enddate>19990317</enddate><creator>McNeal, Monica M</creator><creator>Rae, Mary N</creator><creator>Ward, Richard L</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990317</creationdate><title>Effects of different adjuvants on rotavirus antibody responses and protection in mice following intramuscular immunization with inactivated rotavirus</title><author>McNeal, Monica M ; Rae, Mary N ; Ward, Richard L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-87dbcb64fe12ee32990c9863546b074511fd6143e9200f12257c202fd43567693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adjuvants</topic><topic>Adjuvants, Immunologic</topic><topic>Animals</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intramuscular</topic><topic>Intramuscular immunization</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Rotavirus</topic><topic>Rotavirus - immunology</topic><topic>Rotavirus Infections - prevention & control</topic><topic>Saponins - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, Inactivated - administration & dosage</topic><topic>Vaccines, Inactivated - immunology</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Viral Vaccines - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McNeal, Monica M</creatorcontrib><creatorcontrib>Rae, Mary N</creatorcontrib><creatorcontrib>Ward, Richard L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McNeal, Monica M</au><au>Rae, Mary N</au><au>Ward, Richard L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of different adjuvants on rotavirus antibody responses and protection in mice following intramuscular immunization with inactivated rotavirus</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1999-03-17</date><risdate>1999</risdate><volume>17</volume><issue>11</issue><spage>1573</spage><epage>1580</epage><pages>1573-1580</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract><![CDATA[I.m. immunization of mice with inactivated rotavirus particles protects against subsequent infection. To optimize protection, the effects of different adjuvants (QS-21, QS-7, QUIL A, PCPP and RAS) with potential for human use were compared. Twenty-eight days after i.m. immunization with 20 μg of purified, UV/psoralen-inactivated murine rotavirus (EDIM), either with or without adjuvant, BALB/c mice were orally challenged with live EDIM and virus shedding was measured. All five adjuvants stimulated large (
P<0.001) increases in rotavirus antibody, but significant differences were found between adjuvants. The order of rotavirus IgG responses, i.e. no adjuvant<RAS<QS-7<Quil A<QS-21<PCPP, was the same as the order of protection except that QS-21 and PCPP were reversed. These results establish the importance of adjuvants during i.m. immunization with rotavirus and identify those with the greatest potential.]]></abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10195795</pmid><doi>10.1016/S0264-410X(98)00359-4</doi><tpages>8</tpages></addata></record> |
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| subjects | Adjuvants Adjuvants, Immunologic Animals Antibodies, Viral - biosynthesis Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Injections, Intramuscular Intramuscular immunization Mice Mice, Inbred BALB C Microbiology Rotavirus Rotavirus - immunology Rotavirus Infections - prevention & control Saponins - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Virology |
| title | Effects of different adjuvants on rotavirus antibody responses and protection in mice following intramuscular immunization with inactivated rotavirus |
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