The association of 4a4b polymorphism of endothelial nitric oxide synthase (eNOS) gene with the sperm morphology in Korean infertile men
Objective To investigate the association between three polymorphism sites of endothelial nitric oxide synthase (eNOS; −786T>C, 4a4b, and 894G>T) with nonobstructive male infertility. Design Prospective case-control study. Setting University-based hospital. Patient(s) Three hundred seventy-one...
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| creator | Yun, Yeo-Jin, M.S Park, Jung-Hoon, Ph.D Song, Seung-Hun, M.D Lee, Suman, Ph.D |
| description | Objective To investigate the association between three polymorphism sites of endothelial nitric oxide synthase (eNOS; −786T>C, 4a4b, and 894G>T) with nonobstructive male infertility. Design Prospective case-control study. Setting University-based hospital. Patient(s) Three hundred seventy-one nonobstructive infertile men in azoospermia (n = 184) or ejaculate semen (n = 187) group were enrolled in this study. Two hundred twenty fertile men who had at least one child without any history of requiring assisted reproductive technology were included as the nationwide control group. Intervention(s) Semen analysis according to the World Health Organization guidelines and cytogenetic and Y chromosome microdeletion assay. Main Outcome Measure(s) Three eNOS polymorphisms were investigated to assess its association with male infertility by pyrosequencing and gel electrophoresis. Result(s) The statistical analysis of three eNOS polymorphisms showed no significant association between the polymorphisms of the control and infertile group. We investigated the sperm parameters depending on the genotypes of the ejaculate semen group. The sperm morphology was found to be significantly associated with the 4a4b polymorphism of eNOS. Conclusion(s) Endothelial nitric oxide synthase may be important to sperm morphology in infertile men. |
| doi_str_mv | 10.1016/j.fertnstert.2007.07.1382 |
| format | Article |
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Design Prospective case-control study. Setting University-based hospital. Patient(s) Three hundred seventy-one nonobstructive infertile men in azoospermia (n = 184) or ejaculate semen (n = 187) group were enrolled in this study. Two hundred twenty fertile men who had at least one child without any history of requiring assisted reproductive technology were included as the nationwide control group. Intervention(s) Semen analysis according to the World Health Organization guidelines and cytogenetic and Y chromosome microdeletion assay. Main Outcome Measure(s) Three eNOS polymorphisms were investigated to assess its association with male infertility by pyrosequencing and gel electrophoresis. Result(s) The statistical analysis of three eNOS polymorphisms showed no significant association between the polymorphisms of the control and infertile group. We investigated the sperm parameters depending on the genotypes of the ejaculate semen group. The sperm morphology was found to be significantly associated with the 4a4b polymorphism of eNOS. Conclusion(s) Endothelial nitric oxide synthase may be important to sperm morphology in infertile men.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2007.07.1382</identifier><identifier>PMID: 18539276</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Azoospermia - enzymology ; Azoospermia - epidemiology ; Azoospermia - genetics ; Biological and medical sciences ; Birth control ; eNOS ; Genetic Predisposition to Disease - epidemiology ; Genetic Predisposition to Disease - genetics ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Male - enzymology ; Infertility, Male - epidemiology ; Infertility, Male - genetics ; Internal Medicine ; Korea - epidemiology ; Male ; male infertility ; Medical sciences ; Nitric Oxide Synthase Type III - genetics ; Obstetrics and Gynecology ; Polymorphism, Single Nucleotide - genetics ; Prevalence ; pyrosequencing ; Risk Assessment - methods ; Risk Factors ; single nucleotide polymorphism ; smoking ; sperm parameter ; Spermatozoa - enzymology ; Spermatozoa - pathology ; Sterility. Assisted procreation ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Fertility and sterility, 2008-10, Vol.90 (4), p.1126-1131</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2008 American Society for Reproductive Medicine</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-693680f729b45088dbc639364b225f435f2a9ef6675188cfa39ace0187e9a7633</citedby><cites>FETCH-LOGICAL-c511t-693680f729b45088dbc639364b225f435f2a9ef6675188cfa39ace0187e9a7633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028207030270$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20754596$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18539276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yun, Yeo-Jin, M.S</creatorcontrib><creatorcontrib>Park, Jung-Hoon, Ph.D</creatorcontrib><creatorcontrib>Song, Seung-Hun, M.D</creatorcontrib><creatorcontrib>Lee, Suman, Ph.D</creatorcontrib><title>The association of 4a4b polymorphism of endothelial nitric oxide synthase (eNOS) gene with the sperm morphology in Korean infertile men</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To investigate the association between three polymorphism sites of endothelial nitric oxide synthase (eNOS; −786T>C, 4a4b, and 894G>T) with nonobstructive male infertility. Design Prospective case-control study. Setting University-based hospital. Patient(s) Three hundred seventy-one nonobstructive infertile men in azoospermia (n = 184) or ejaculate semen (n = 187) group were enrolled in this study. Two hundred twenty fertile men who had at least one child without any history of requiring assisted reproductive technology were included as the nationwide control group. Intervention(s) Semen analysis according to the World Health Organization guidelines and cytogenetic and Y chromosome microdeletion assay. Main Outcome Measure(s) Three eNOS polymorphisms were investigated to assess its association with male infertility by pyrosequencing and gel electrophoresis. Result(s) The statistical analysis of three eNOS polymorphisms showed no significant association between the polymorphisms of the control and infertile group. We investigated the sperm parameters depending on the genotypes of the ejaculate semen group. The sperm morphology was found to be significantly associated with the 4a4b polymorphism of eNOS. Conclusion(s) Endothelial nitric oxide synthase may be important to sperm morphology in infertile men.</description><subject>Azoospermia - enzymology</subject><subject>Azoospermia - epidemiology</subject><subject>Azoospermia - genetics</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>eNOS</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infertility, Male - enzymology</subject><subject>Infertility, Male - epidemiology</subject><subject>Infertility, Male - genetics</subject><subject>Internal Medicine</subject><subject>Korea - epidemiology</subject><subject>Male</subject><subject>male infertility</subject><subject>Medical sciences</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Obstetrics and Gynecology</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Prevalence</subject><subject>pyrosequencing</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>single nucleotide polymorphism</subject><subject>smoking</subject><subject>sperm parameter</subject><subject>Spermatozoa - enzymology</subject><subject>Spermatozoa - pathology</subject><subject>Sterility. Assisted procreation</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt-P1CAQxxuj8dbTf8Hgg0YfugIt0L6YmI2_4sV7uPOZUDpcWVvoAav2L_DflrobL_HJZDKQyWe-AzNTFM8I3hJM-Ov91kBILqbstxRjsc1GqobeKzaEMV4yzqr7xQZjwkpMG3pWPIpxjzHmRNCHxRlpWNVSwTfFr-sBkIrRa6uS9Q55g2pVd2j24zL5MA82TmsQXO_TAKNVI3I2BauR_2l7QHFxaVAR0Ev4cnn1Ct2AA_TDpgFlHMUZwoT-CPnR3yzIOvTZB1Au39Zf2BHQBO5x8cCoMcKT03lefH3_7nr3sby4_PBp9_ai1IyQVPK24g02grZdzXDT9J3mVY7VHaXM1BUzVLVgOBeMNI02qmqVBkwaAa0SvKrOixdH3Tn42wPEJCcbNYyjcuAPUfKWi6wuMtgeQR18jAGMnIOdVFgkwXKdgtzLuynIdQoy2zqFnPv0VOTQTdDfZZ7anoHnJ0BFrUYTlNM2_uUoFqxm7crtjhzklny3EGTUFpyG3gbQSfbe_tdz3vyjokfrbC78DRaIe38ILvdcEhmpxPJqXZt1a7DAFabZ_QbhwMGI</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Yun, Yeo-Jin, M.S</creator><creator>Park, Jung-Hoon, Ph.D</creator><creator>Song, Seung-Hun, M.D</creator><creator>Lee, Suman, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>The association of 4a4b polymorphism of endothelial nitric oxide synthase (eNOS) gene with the sperm morphology in Korean infertile men</title><author>Yun, Yeo-Jin, M.S ; Park, Jung-Hoon, Ph.D ; Song, Seung-Hun, M.D ; Lee, Suman, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-693680f729b45088dbc639364b225f435f2a9ef6675188cfa39ace0187e9a7633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Azoospermia - enzymology</topic><topic>Azoospermia - epidemiology</topic><topic>Azoospermia - genetics</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>eNOS</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infertility, Male - enzymology</topic><topic>Infertility, Male - epidemiology</topic><topic>Infertility, Male - genetics</topic><topic>Internal Medicine</topic><topic>Korea - epidemiology</topic><topic>Male</topic><topic>male infertility</topic><topic>Medical sciences</topic><topic>Nitric Oxide Synthase Type III - genetics</topic><topic>Obstetrics and Gynecology</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Prevalence</topic><topic>pyrosequencing</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>single nucleotide polymorphism</topic><topic>smoking</topic><topic>sperm parameter</topic><topic>Spermatozoa - enzymology</topic><topic>Spermatozoa - pathology</topic><topic>Sterility. Assisted procreation</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yun, Yeo-Jin, M.S</creatorcontrib><creatorcontrib>Park, Jung-Hoon, Ph.D</creatorcontrib><creatorcontrib>Song, Seung-Hun, M.D</creatorcontrib><creatorcontrib>Lee, Suman, Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yun, Yeo-Jin, M.S</au><au>Park, Jung-Hoon, Ph.D</au><au>Song, Seung-Hun, M.D</au><au>Lee, Suman, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of 4a4b polymorphism of endothelial nitric oxide synthase (eNOS) gene with the sperm morphology in Korean infertile men</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>90</volume><issue>4</issue><spage>1126</spage><epage>1131</epage><pages>1126-1131</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To investigate the association between three polymorphism sites of endothelial nitric oxide synthase (eNOS; −786T>C, 4a4b, and 894G>T) with nonobstructive male infertility. Design Prospective case-control study. Setting University-based hospital. Patient(s) Three hundred seventy-one nonobstructive infertile men in azoospermia (n = 184) or ejaculate semen (n = 187) group were enrolled in this study. Two hundred twenty fertile men who had at least one child without any history of requiring assisted reproductive technology were included as the nationwide control group. Intervention(s) Semen analysis according to the World Health Organization guidelines and cytogenetic and Y chromosome microdeletion assay. Main Outcome Measure(s) Three eNOS polymorphisms were investigated to assess its association with male infertility by pyrosequencing and gel electrophoresis. Result(s) The statistical analysis of three eNOS polymorphisms showed no significant association between the polymorphisms of the control and infertile group. We investigated the sperm parameters depending on the genotypes of the ejaculate semen group. The sperm morphology was found to be significantly associated with the 4a4b polymorphism of eNOS. Conclusion(s) Endothelial nitric oxide synthase may be important to sperm morphology in infertile men.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18539276</pmid><doi>10.1016/j.fertnstert.2007.07.1382</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 2008-10, Vol.90 (4), p.1126-1131 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Azoospermia - enzymology Azoospermia - epidemiology Azoospermia - genetics Biological and medical sciences Birth control eNOS Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Gynecology. Andrology. Obstetrics Humans Infertility, Male - enzymology Infertility, Male - epidemiology Infertility, Male - genetics Internal Medicine Korea - epidemiology Male male infertility Medical sciences Nitric Oxide Synthase Type III - genetics Obstetrics and Gynecology Polymorphism, Single Nucleotide - genetics Prevalence pyrosequencing Risk Assessment - methods Risk Factors single nucleotide polymorphism smoking sperm parameter Spermatozoa - enzymology Spermatozoa - pathology Sterility. Assisted procreation Tobacco, tobacco smoking Toxicology |
| title | The association of 4a4b polymorphism of endothelial nitric oxide synthase (eNOS) gene with the sperm morphology in Korean infertile men |
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