Formation of Hyaluronan- and Versican-Rich Pericellular Matrix Is Required for Proliferation and Migration of Vascular Smooth Muscle Cells

The accumulation of hyaluronan (HA) and the HA-binding proteoglycan versican around smooth muscle cells in lesions of atherosclerosis suggests that together these molecules play an important role in the events of atherogenesis. In this study we have examined the formation of HA- and versican-rich pe...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1999-04, Vol.19 (4), p.1004-1013
Hauptverfasser:	Evanko, Stephen P, Angello, John C, Wight, Thomas N
Format:	Artikel
Sprache:	eng
Schlagworte:	Aorta, Thoracic Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Division - drug effects Cell Division - physiology Cell Movement - drug effects Cell Movement - physiology Cells, Cultured Chondroitin Sulfate Proteoglycans - metabolism Chondroitin Sulfate Proteoglycans - ultrastructure Extracellular Matrix - metabolism Extracellular Matrix - physiology Extracellular Matrix - ultrastructure Humans Hyaluronic Acid - metabolism Hyaluronic Acid - ultrastructure Infant, Newborn Lectins, C-Type Medical sciences Mitosis - physiology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiology Oligosaccharides - pharmacology Versicans
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