Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis
Platensimycins B(1)-B(3) are natural congeners of platensimycin with modest to significant changes in the benzoic acid portion of the molecule, leading to attenuation in the biological activities and thus confirming the significance of the free carboxylate for the potent activity.
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2008-10 (40), p.5034-5036 |
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| container_issue | 40 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Zhang, Chaowei Ondeyka, John Zink, Deborah L Burgess, Bruce Wang, Jun Singh, Sheo B |
| description | Platensimycins B(1)-B(3) are natural congeners of platensimycin with modest to significant changes in the benzoic acid portion of the molecule, leading to attenuation in the biological activities and thus confirming the significance of the free carboxylate for the potent activity. |
| doi_str_mv | 10.1039/b810113b |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2008-10 (40), p.5034-5036 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - antagonists & inhibitors 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - metabolism Adamantane - chemistry Adamantane - isolation & purification Adamantane - metabolism Adamantane - pharmacology Aminobenzoates - chemistry Aminobenzoates - isolation & purification Aminobenzoates - metabolism Aminobenzoates - pharmacology Anilides - chemistry Anilides - isolation & purification Anilides - metabolism Anilides - pharmacology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Fatty Acids - biosynthesis Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology Streptomyces - chemistry |
| title | Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis |
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