Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats
Taurine is a sulfur amino acid that is present in high concentration in mammalian tissues and previously has been reported to decline in a number of tissues with advancing age. The aims of the present study were to examine: (1) the effects of dietary taurine supplementation; (2) the effects of tauri...
Gespeichert in:
| Veröffentlicht in: | Mechanisms of ageing and development 1999-02, Vol.107 (1), p.73-91 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 91 |
|---|---|
| container_issue | 1 |
| container_start_page | 73 |
| container_title | Mechanisms of ageing and development |
| container_volume | 107 |
| creator | Dawson, Ralph Liu, Steven Eppler, Baerbel Patterson, Tucker |
| description | Taurine is a sulfur amino acid that is present in high concentration in mammalian tissues and previously has been reported to decline in a number of tissues with advancing age. The aims of the present study were to examine: (1) the effects of dietary taurine supplementation; (2) the effects of taurine-free diets; (3) the ability of aged rats to conserve urinary taurine; and (4) the consequences of these dietary manipulations on some biochemical parameters. Male F344 rats (
n=30/group) 18 months of age were placed on control diets, diets supplemented with 1.5% taurine in the drinking water, or a taurine-free diet for 10 months. An adult control group (12 months old at the end of the study) on normal diets was included for comparison purposes. Significant (
P |
| doi_str_mv | 10.1016/S0047-6374(98)00138-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69676200</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0047637498001389</els_id><sourcerecordid>69676200</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-f2e80a55b6c817609d12a7d23857aca173dcc5a60b6a39150a89d570b87ae5f23</originalsourceid><addsrcrecordid>eNqFkUlrFUEQgBtRzEv0Jxj6IJIcRnuZ3k5BQhYh4CERj0297hptmeXZPRPw36eTeURvnoqCr7avCHnH2UfOuP50y1hrGi1Ne-LsKWNc2sa9IBtujWi04Pol2TwjB-SwlF-sUq3Qr8lB7eCMcWxDvl90HYa50KmjMeEM-Q-dYclpRFqW3a7HAccZ5jSNdMo04i6n-zVNI4UfGOkAPdLLVMJPzFS2Lc0wlzfkVQd9wbf7eES-XV7cnV83N1-vvpx_vmlCq_TcdAItA6W2OlhuNHORCzBRSKsMBOBGxhAUaLbVIB1XDKyLyrCtNYCqE_KIfFj77vL0e8Ey-6Fugn0PI05L8dppowVjFVQrGPJUSsbO10uGeq7nzD8a9U9G_aMu76x_MupdrTveD1i2A8Z_qlaFFXi_B6AE6LsMY0jlL2ekEEpW7GzFsNq4T5h9CQnHgDHl-gAfp_SfTR4AqVmR3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69676200</pqid></control><display><type>article</type><title>Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Dawson, Ralph ; Liu, Steven ; Eppler, Baerbel ; Patterson, Tucker</creator><creatorcontrib>Dawson, Ralph ; Liu, Steven ; Eppler, Baerbel ; Patterson, Tucker</creatorcontrib><description>Taurine is a sulfur amino acid that is present in high concentration in mammalian tissues and previously has been reported to decline in a number of tissues with advancing age. The aims of the present study were to examine: (1) the effects of dietary taurine supplementation; (2) the effects of taurine-free diets; (3) the ability of aged rats to conserve urinary taurine; and (4) the consequences of these dietary manipulations on some biochemical parameters. Male F344 rats (
n=30/group) 18 months of age were placed on control diets, diets supplemented with 1.5% taurine in the drinking water, or a taurine-free diet for 10 months. An adult control group (12 months old at the end of the study) on normal diets was included for comparison purposes. Significant (
P<0.05) age-related declines in taurine content were observed in the spleen, kidney, eye, cerebellum and serum. Taurine supplementation corrected these deficits in tissue content in aged rats and in many cases increased taurine content above that of adult controls. Urinary excretion of taurine was significantly (
P<0.05) reduced in aged rats indicating an increased need to conserve taurine. Taurine-deficient diets did not further exacerbate the age-related decline in tissue taurine content, suggesting biosynthetic adaptations to the lack of dietary taurine. Dietary taurine supplementation blunted age-related declines in serum IGF-1 and increases in serum creatinine and blood urinary nitrogen (BUN). These studies suggest that advanced aging results in a taurine-deficient state that can be corrected by dietary supplementation.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/S0047-6374(98)00138-9</identifier><identifier>PMID: 10197790</identifier><identifier>CODEN: MAGDA3</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aging ; Aging - metabolism ; Animals ; Biological and medical sciences ; Blood Urea Nitrogen ; Body Weight ; Brain - metabolism ; Chromatography, High Pressure Liquid ; Creatine - blood ; Dietary antioxidants ; Eye - metabolism ; Feeding. Feeding behavior ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Homeostasis ; Insulin-Like Growth Factor I - metabolism ; Kidney - metabolism ; Male ; Rats ; Rats, Inbred F344 ; Spleen - metabolism ; Sulfur amino acids ; Taurine ; Taurine - administration & dosage ; Taurine - deficiency ; Taurine - physiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Mechanisms of ageing and development, 1999-02, Vol.107 (1), p.73-91</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-f2e80a55b6c817609d12a7d23857aca173dcc5a60b6a39150a89d570b87ae5f23</citedby><cites>FETCH-LOGICAL-c456t-f2e80a55b6c817609d12a7d23857aca173dcc5a60b6a39150a89d570b87ae5f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0047637498001389$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1732253$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10197790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dawson, Ralph</creatorcontrib><creatorcontrib>Liu, Steven</creatorcontrib><creatorcontrib>Eppler, Baerbel</creatorcontrib><creatorcontrib>Patterson, Tucker</creatorcontrib><title>Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>Taurine is a sulfur amino acid that is present in high concentration in mammalian tissues and previously has been reported to decline in a number of tissues with advancing age. The aims of the present study were to examine: (1) the effects of dietary taurine supplementation; (2) the effects of taurine-free diets; (3) the ability of aged rats to conserve urinary taurine; and (4) the consequences of these dietary manipulations on some biochemical parameters. Male F344 rats (
n=30/group) 18 months of age were placed on control diets, diets supplemented with 1.5% taurine in the drinking water, or a taurine-free diet for 10 months. An adult control group (12 months old at the end of the study) on normal diets was included for comparison purposes. Significant (
P<0.05) age-related declines in taurine content were observed in the spleen, kidney, eye, cerebellum and serum. Taurine supplementation corrected these deficits in tissue content in aged rats and in many cases increased taurine content above that of adult controls. Urinary excretion of taurine was significantly (
P<0.05) reduced in aged rats indicating an increased need to conserve taurine. Taurine-deficient diets did not further exacerbate the age-related decline in tissue taurine content, suggesting biosynthetic adaptations to the lack of dietary taurine. Dietary taurine supplementation blunted age-related declines in serum IGF-1 and increases in serum creatinine and blood urinary nitrogen (BUN). These studies suggest that advanced aging results in a taurine-deficient state that can be corrected by dietary supplementation.</description><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Urea Nitrogen</subject><subject>Body Weight</subject><subject>Brain - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Creatine - blood</subject><subject>Dietary antioxidants</subject><subject>Eye - metabolism</subject><subject>Feeding. Feeding behavior</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Homeostasis</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Spleen - metabolism</subject><subject>Sulfur amino acids</subject><subject>Taurine</subject><subject>Taurine - administration & dosage</subject><subject>Taurine - deficiency</subject><subject>Taurine - physiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUlrFUEQgBtRzEv0Jxj6IJIcRnuZ3k5BQhYh4CERj0297hptmeXZPRPw36eTeURvnoqCr7avCHnH2UfOuP50y1hrGi1Ne-LsKWNc2sa9IBtujWi04Pol2TwjB-SwlF-sUq3Qr8lB7eCMcWxDvl90HYa50KmjMeEM-Q-dYclpRFqW3a7HAccZ5jSNdMo04i6n-zVNI4UfGOkAPdLLVMJPzFS2Lc0wlzfkVQd9wbf7eES-XV7cnV83N1-vvpx_vmlCq_TcdAItA6W2OlhuNHORCzBRSKsMBOBGxhAUaLbVIB1XDKyLyrCtNYCqE_KIfFj77vL0e8Ey-6Fugn0PI05L8dppowVjFVQrGPJUSsbO10uGeq7nzD8a9U9G_aMu76x_MupdrTveD1i2A8Z_qlaFFXi_B6AE6LsMY0jlL2ekEEpW7GzFsNq4T5h9CQnHgDHl-gAfp_SfTR4AqVmR3w</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Dawson, Ralph</creator><creator>Liu, Steven</creator><creator>Eppler, Baerbel</creator><creator>Patterson, Tucker</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats</title><author>Dawson, Ralph ; Liu, Steven ; Eppler, Baerbel ; Patterson, Tucker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-f2e80a55b6c817609d12a7d23857aca173dcc5a60b6a39150a89d570b87ae5f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Urea Nitrogen</topic><topic>Body Weight</topic><topic>Brain - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Creatine - blood</topic><topic>Dietary antioxidants</topic><topic>Eye - metabolism</topic><topic>Feeding. Feeding behavior</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Homeostasis</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Spleen - metabolism</topic><topic>Sulfur amino acids</topic><topic>Taurine</topic><topic>Taurine - administration & dosage</topic><topic>Taurine - deficiency</topic><topic>Taurine - physiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dawson, Ralph</creatorcontrib><creatorcontrib>Liu, Steven</creatorcontrib><creatorcontrib>Eppler, Baerbel</creatorcontrib><creatorcontrib>Patterson, Tucker</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dawson, Ralph</au><au>Liu, Steven</au><au>Eppler, Baerbel</au><au>Patterson, Tucker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>107</volume><issue>1</issue><spage>73</spage><epage>91</epage><pages>73-91</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><coden>MAGDA3</coden><abstract>Taurine is a sulfur amino acid that is present in high concentration in mammalian tissues and previously has been reported to decline in a number of tissues with advancing age. The aims of the present study were to examine: (1) the effects of dietary taurine supplementation; (2) the effects of taurine-free diets; (3) the ability of aged rats to conserve urinary taurine; and (4) the consequences of these dietary manipulations on some biochemical parameters. Male F344 rats (
n=30/group) 18 months of age were placed on control diets, diets supplemented with 1.5% taurine in the drinking water, or a taurine-free diet for 10 months. An adult control group (12 months old at the end of the study) on normal diets was included for comparison purposes. Significant (
P<0.05) age-related declines in taurine content were observed in the spleen, kidney, eye, cerebellum and serum. Taurine supplementation corrected these deficits in tissue content in aged rats and in many cases increased taurine content above that of adult controls. Urinary excretion of taurine was significantly (
P<0.05) reduced in aged rats indicating an increased need to conserve taurine. Taurine-deficient diets did not further exacerbate the age-related decline in tissue taurine content, suggesting biosynthetic adaptations to the lack of dietary taurine. Dietary taurine supplementation blunted age-related declines in serum IGF-1 and increases in serum creatinine and blood urinary nitrogen (BUN). These studies suggest that advanced aging results in a taurine-deficient state that can be corrected by dietary supplementation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10197790</pmid><doi>10.1016/S0047-6374(98)00138-9</doi><tpages>19</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0047-6374 |
| ispartof | Mechanisms of ageing and development, 1999-02, Vol.107 (1), p.73-91 |
| issn | 0047-6374 1872-6216 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69676200 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aging Aging - metabolism Animals Biological and medical sciences Blood Urea Nitrogen Body Weight Brain - metabolism Chromatography, High Pressure Liquid Creatine - blood Dietary antioxidants Eye - metabolism Feeding. Feeding behavior Follow-Up Studies Fundamental and applied biological sciences. Psychology Homeostasis Insulin-Like Growth Factor I - metabolism Kidney - metabolism Male Rats Rats, Inbred F344 Spleen - metabolism Sulfur amino acids Taurine Taurine - administration & dosage Taurine - deficiency Taurine - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T07%3A46%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20dietary%20taurine%20supplementation%20or%20deprivation%20in%20aged%20male%20Fischer%20344%20rats&rft.jtitle=Mechanisms%20of%20ageing%20and%20development&rft.au=Dawson,%20Ralph&rft.date=1999-02-01&rft.volume=107&rft.issue=1&rft.spage=73&rft.epage=91&rft.pages=73-91&rft.issn=0047-6374&rft.eissn=1872-6216&rft.coden=MAGDA3&rft_id=info:doi/10.1016/S0047-6374(98)00138-9&rft_dat=%3Cproquest_cross%3E69676200%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69676200&rft_id=info:pmid/10197790&rft_els_id=S0047637498001389&rfr_iscdi=true |