Aldehydic components of Cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation

Cinnamomum zeylanicum exhibited the strong inhibitory effects on osteoclastogenesis and that its mechanism of action involved the suppression of NFATc1-mediated signal transduction. In addition, cinnamaldehyde and 2-methoxycinnamaldehyde were identified as its active components. Several major bone d...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-10, Vol.16 (20), p.9176-9183
1. Verfasser:	Tsuji-Naito, Kentaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Aldehydes - isolation & purification Aldehydes - pharmacology Animals Cell Differentiation - drug effects Cell Line Cinnamomum zeylanicum Cinnamomum zeylanicum - chemistry Down-Regulation - drug effects Mice Molecular Structure NF-kappa B - metabolism NFATC Transcription Factors - metabolism NFATc1 Osteoclastogenesis Osteoclasts - cytology Osteoclasts - metabolism Plant Bark - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Proto-Oncogene Proteins c-fos - metabolism RANK Ligand - metabolism RANKL Signal Transduction - drug effects
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