Isosorbide-2-carbamate Esters: Potent and Selective Butyrylcholinesterase Inhibitors

In this study, we report the SAR and characterization of two groups of isosorbide-based cholinesterase inhibitors. The first was based directly on the clinically used nitrate isosorbide mononitrate (ISMN) retention of the 5-nitrate group and introduction of a series of 2-carbamate functionalities. T...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-10, Vol.51 (20), p.6400-6409
Hauptverfasser:	Carolan, Ciaran G, Dillon, Gerald P, Gaynor, Joanne M, Reidy, Sean, Ryder, Sheila A, Khan, Denise, Marquez, Juan F, Gilmer, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Butyrylcholinesterase - metabolism Carbamates - chemistry Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Esters - chemical synthesis Esters - chemistry Esters - pharmacology Humans Isosorbide - chemistry Medical sciences Models, Molecular Molecular Structure Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Structure-Activity Relationship
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