Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle
Inclusion body myositis (IBM) is the most common myopathy in people over 50 years of age. It involves an inflammatory process that, paradoxically, does not respond to anti-inflammatory drugs. A key feature of IBM is the presence of amyloid-β-peptide aggregates called amyloid deposits, which are also...
Gespeichert in:
| Veröffentlicht in: | Molecular neurobiology 2008-10, Vol.38 (2), p.178-198 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 198 |
|---|---|
| container_issue | 2 |
| container_start_page | 178 |
| container_title | Molecular neurobiology |
| container_volume | 38 |
| creator | Rebolledo, Daniela L. Minniti, Alicia N. Grez, Paula M. Fadic, Ricardo Kohn, Rebecca Inestrosa, Nibaldo C. |
| description | Inclusion body myositis (IBM) is the most common myopathy in people over 50 years of age. It involves an inflammatory process that, paradoxically, does not respond to anti-inflammatory drugs. A key feature of IBM is the presence of amyloid-β-peptide aggregates called amyloid deposits, which are also characteristic of Alzheimer’s disease. The use of animals that mimic at least some characteristics of a disease has become very important in the quest to elucidate the molecular mechanisms underlying this and other pathogeneses. Although there are some transgenic mouse strains that recreate some aspects of IBM, in this review, we hypothesize that the great degree of similarity between nematode and human genes known to be involved in IBM as well as the considerable conservation of biological mechanisms across species is an important feature that must be taken into consideration when deciding on the use of this nematode as a model. Straightforward laboratory techniques (culture, transformation, gene knockdown, genetic screenings, etc.) as well as anatomical, physiological, and behavioral characteristics add to the value of this model. In the present work, we review evidence that supports the use of
Caenorhabditis elegans
as a biological model for IBM. |
| doi_str_mv | 10.1007/s12035-008-8041-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69672581</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21269761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-59775501d378058a63c085dd4cfe3774609f7c5e7f5c54542367ae63efa1290d3</originalsourceid><addsrcrecordid>eNqFkU9rGzEQxUVJadykH6CXInLobdsZafVnc3NMnRhieml6FbJ2NtmwXjmSl-Bv3zU2GAKhpzm833vDzGPsK8IPBDA_MwqQqgCwhYUSC_jAJqhUVSBaccYmYCtZGF3ac_Y552cAIRDMJ3aO1hgpESdsvuhDN-Q29vwm1ju-3MXcbtt8zaf8b0uvvElxzbdPxGee-pie_Kre65w6evR95sshh44u2cfGd5m-HOcFe5j_-jO7K-5_3y5m0_silADbQlXGKAVYS2NBWa9lAKvqugwNSWNKDVVjgiLTqKBKVQqpjSctqfEoKqjlBft-yN2k-DJQ3rp1mwN1ne8pDtnpShuhLP4XFCh0ZfQevHoDPsch9eMRI1NaAFDVCOEBCinmnKhxm9Sufdo5BLevwh2qcGMVbl-Fg9Hz7Rg8rNZUnxzH34-AOAB5lPpHSqfN76f-A_mYkPk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214800059</pqid></control><display><type>article</type><title>Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Rebolledo, Daniela L. ; Minniti, Alicia N. ; Grez, Paula M. ; Fadic, Ricardo ; Kohn, Rebecca ; Inestrosa, Nibaldo C.</creator><creatorcontrib>Rebolledo, Daniela L. ; Minniti, Alicia N. ; Grez, Paula M. ; Fadic, Ricardo ; Kohn, Rebecca ; Inestrosa, Nibaldo C.</creatorcontrib><description>Inclusion body myositis (IBM) is the most common myopathy in people over 50 years of age. It involves an inflammatory process that, paradoxically, does not respond to anti-inflammatory drugs. A key feature of IBM is the presence of amyloid-β-peptide aggregates called amyloid deposits, which are also characteristic of Alzheimer’s disease. The use of animals that mimic at least some characteristics of a disease has become very important in the quest to elucidate the molecular mechanisms underlying this and other pathogeneses. Although there are some transgenic mouse strains that recreate some aspects of IBM, in this review, we hypothesize that the great degree of similarity between nematode and human genes known to be involved in IBM as well as the considerable conservation of biological mechanisms across species is an important feature that must be taken into consideration when deciding on the use of this nematode as a model. Straightforward laboratory techniques (culture, transformation, gene knockdown, genetic screenings, etc.) as well as anatomical, physiological, and behavioral characteristics add to the value of this model. In the present work, we review evidence that supports the use of
Caenorhabditis elegans
as a biological model for IBM.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-008-8041-0</identifier><identifier>PMID: 18773311</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Amyloid beta-Peptides - genetics ; Amyloid beta-Peptides - metabolism ; Amyloid beta-Protein Precursor - genetics ; Amyloid beta-Protein Precursor - metabolism ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Caenorhabditis elegans ; Caenorhabditis elegans - anatomy & histology ; Caenorhabditis elegans - genetics ; Cell Biology ; Disease Models, Animal ; Humans ; Metals - metabolism ; Mitochondria - metabolism ; Muscles - metabolism ; Muscles - pathology ; Muscular system ; Myositis, Inclusion Body - metabolism ; Myositis, Inclusion Body - pathology ; Nematoda ; Neurobiology ; Neurology ; Neurosciences ; Oxidative Stress ; Peptides ; Peptides - genetics ; Peptides - metabolism ; RNA Interference ; Studies ; Worms</subject><ispartof>Molecular neurobiology, 2008-10, Vol.38 (2), p.178-198</ispartof><rights>Humana Press Inc. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-59775501d378058a63c085dd4cfe3774609f7c5e7f5c54542367ae63efa1290d3</citedby><cites>FETCH-LOGICAL-c400t-59775501d378058a63c085dd4cfe3774609f7c5e7f5c54542367ae63efa1290d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-008-8041-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-008-8041-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18773311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rebolledo, Daniela L.</creatorcontrib><creatorcontrib>Minniti, Alicia N.</creatorcontrib><creatorcontrib>Grez, Paula M.</creatorcontrib><creatorcontrib>Fadic, Ricardo</creatorcontrib><creatorcontrib>Kohn, Rebecca</creatorcontrib><creatorcontrib>Inestrosa, Nibaldo C.</creatorcontrib><title>Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Inclusion body myositis (IBM) is the most common myopathy in people over 50 years of age. It involves an inflammatory process that, paradoxically, does not respond to anti-inflammatory drugs. A key feature of IBM is the presence of amyloid-β-peptide aggregates called amyloid deposits, which are also characteristic of Alzheimer’s disease. The use of animals that mimic at least some characteristics of a disease has become very important in the quest to elucidate the molecular mechanisms underlying this and other pathogeneses. Although there are some transgenic mouse strains that recreate some aspects of IBM, in this review, we hypothesize that the great degree of similarity between nematode and human genes known to be involved in IBM as well as the considerable conservation of biological mechanisms across species is an important feature that must be taken into consideration when deciding on the use of this nematode as a model. Straightforward laboratory techniques (culture, transformation, gene knockdown, genetic screenings, etc.) as well as anatomical, physiological, and behavioral characteristics add to the value of this model. In the present work, we review evidence that supports the use of
Caenorhabditis elegans
as a biological model for IBM.</description><subject>Amyloid beta-Peptides - genetics</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Amyloid beta-Protein Precursor - genetics</subject><subject>Amyloid beta-Protein Precursor - metabolism</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - anatomy & histology</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Cell Biology</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Metals - metabolism</subject><subject>Mitochondria - metabolism</subject><subject>Muscles - metabolism</subject><subject>Muscles - pathology</subject><subject>Muscular system</subject><subject>Myositis, Inclusion Body - metabolism</subject><subject>Myositis, Inclusion Body - pathology</subject><subject>Nematoda</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Oxidative Stress</subject><subject>Peptides</subject><subject>Peptides - genetics</subject><subject>Peptides - metabolism</subject><subject>RNA Interference</subject><subject>Studies</subject><subject>Worms</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU9rGzEQxUVJadykH6CXInLobdsZafVnc3NMnRhieml6FbJ2NtmwXjmSl-Bv3zU2GAKhpzm833vDzGPsK8IPBDA_MwqQqgCwhYUSC_jAJqhUVSBaccYmYCtZGF3ac_Y552cAIRDMJ3aO1hgpESdsvuhDN-Q29vwm1ju-3MXcbtt8zaf8b0uvvElxzbdPxGee-pie_Kre65w6evR95sshh44u2cfGd5m-HOcFe5j_-jO7K-5_3y5m0_silADbQlXGKAVYS2NBWa9lAKvqugwNSWNKDVVjgiLTqKBKVQqpjSctqfEoKqjlBft-yN2k-DJQ3rp1mwN1ne8pDtnpShuhLP4XFCh0ZfQevHoDPsch9eMRI1NaAFDVCOEBCinmnKhxm9Sufdo5BLevwh2qcGMVbl-Fg9Hz7Rg8rNZUnxzH34-AOAB5lPpHSqfN76f-A_mYkPk</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Rebolledo, Daniela L.</creator><creator>Minniti, Alicia N.</creator><creator>Grez, Paula M.</creator><creator>Fadic, Ricardo</creator><creator>Kohn, Rebecca</creator><creator>Inestrosa, Nibaldo C.</creator><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle</title><author>Rebolledo, Daniela L. ; Minniti, Alicia N. ; Grez, Paula M. ; Fadic, Ricardo ; Kohn, Rebecca ; Inestrosa, Nibaldo C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-59775501d378058a63c085dd4cfe3774609f7c5e7f5c54542367ae63efa1290d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Amyloid beta-Peptides - genetics</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Amyloid beta-Protein Precursor - genetics</topic><topic>Amyloid beta-Protein Precursor - metabolism</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - anatomy & histology</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Cell Biology</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Metals - metabolism</topic><topic>Mitochondria - metabolism</topic><topic>Muscles - metabolism</topic><topic>Muscles - pathology</topic><topic>Muscular system</topic><topic>Myositis, Inclusion Body - metabolism</topic><topic>Myositis, Inclusion Body - pathology</topic><topic>Nematoda</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Oxidative Stress</topic><topic>Peptides</topic><topic>Peptides - genetics</topic><topic>Peptides - metabolism</topic><topic>RNA Interference</topic><topic>Studies</topic><topic>Worms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rebolledo, Daniela L.</creatorcontrib><creatorcontrib>Minniti, Alicia N.</creatorcontrib><creatorcontrib>Grez, Paula M.</creatorcontrib><creatorcontrib>Fadic, Ricardo</creatorcontrib><creatorcontrib>Kohn, Rebecca</creatorcontrib><creatorcontrib>Inestrosa, Nibaldo C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rebolledo, Daniela L.</au><au>Minniti, Alicia N.</au><au>Grez, Paula M.</au><au>Fadic, Ricardo</au><au>Kohn, Rebecca</au><au>Inestrosa, Nibaldo C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>38</volume><issue>2</issue><spage>178</spage><epage>198</epage><pages>178-198</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Inclusion body myositis (IBM) is the most common myopathy in people over 50 years of age. It involves an inflammatory process that, paradoxically, does not respond to anti-inflammatory drugs. A key feature of IBM is the presence of amyloid-β-peptide aggregates called amyloid deposits, which are also characteristic of Alzheimer’s disease. The use of animals that mimic at least some characteristics of a disease has become very important in the quest to elucidate the molecular mechanisms underlying this and other pathogeneses. Although there are some transgenic mouse strains that recreate some aspects of IBM, in this review, we hypothesize that the great degree of similarity between nematode and human genes known to be involved in IBM as well as the considerable conservation of biological mechanisms across species is an important feature that must be taken into consideration when deciding on the use of this nematode as a model. Straightforward laboratory techniques (culture, transformation, gene knockdown, genetic screenings, etc.) as well as anatomical, physiological, and behavioral characteristics add to the value of this model. In the present work, we review evidence that supports the use of
Caenorhabditis elegans
as a biological model for IBM.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>18773311</pmid><doi>10.1007/s12035-008-8041-0</doi><tpages>21</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-7648 |
| ispartof | Molecular neurobiology, 2008-10, Vol.38 (2), p.178-198 |
| issn | 0893-7648 1559-1182 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69672581 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Biomedical and Life Sciences Biomedicine Caenorhabditis elegans Caenorhabditis elegans - anatomy & histology Caenorhabditis elegans - genetics Cell Biology Disease Models, Animal Humans Metals - metabolism Mitochondria - metabolism Muscles - metabolism Muscles - pathology Muscular system Myositis, Inclusion Body - metabolism Myositis, Inclusion Body - pathology Nematoda Neurobiology Neurology Neurosciences Oxidative Stress Peptides Peptides - genetics Peptides - metabolism RNA Interference Studies Worms |
| title | Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T14%3A06%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inclusion%20Body%20Myositis:%20A%20View%20from%20the%20Caenorhabditis%20elegans%20Muscle&rft.jtitle=Molecular%20neurobiology&rft.au=Rebolledo,%20Daniela%20L.&rft.date=2008-10-01&rft.volume=38&rft.issue=2&rft.spage=178&rft.epage=198&rft.pages=178-198&rft.issn=0893-7648&rft.eissn=1559-1182&rft_id=info:doi/10.1007/s12035-008-8041-0&rft_dat=%3Cproquest_cross%3E21269761%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=214800059&rft_id=info:pmid/18773311&rfr_iscdi=true |