Differences in extra-cellular matrix and myocyte homeostasis between the neonatal right ventricle in hypoplastic left heart syndrome and truncus arteriosus

Objective: The right ventricle in hypoplastic left heart syndrome (HLHS) works at systemic pressure and large volume loading before and after first stage palliation. There is a paucity of information regarding the intrinsic characteristics of the right ventricle in HLHS. We studied extra-cellular ma...

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Veröffentlicht in:	European journal of cardio-thoracic surgery 2008-10, Vol.34 (4), p.738-744
Hauptverfasser:	Davies, Ben, d’Udekem, Yves, Ukoumunne, Obioha C., Algar, Elizabeth M., Newgreen, Donald F., Brizard, Christian Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Cardiology. Vascular system Cell Division Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava Cross-Sectional Studies Extra-cellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Extracellular Matrix Proteins - metabolism Female Heart Heart Ventricles - metabolism Heart Ventricles - pathology Homeobox Protein Nkx-2.5 Homeodomain Proteins - metabolism Homeostasis Humans Hypoplastic left heart syndrome Hypoplastic Left Heart Syndrome - metabolism Hypoplastic Left Heart Syndrome - pathology Image Processing, Computer-Assisted - methods Infant Infant, Newborn Male Medical sciences Muscle Cells - pathology Muscle Cells - physiology Myocardium Pneumology Polymerase Chain Reaction - methods Right ventricle Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Transcription Factors - metabolism Truncus Arteriosus, Persistent - metabolism Truncus Arteriosus, Persistent - pathology
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