Regulatable Expression of the Interferon-Induced Double-Stranded RNA Dependent Protein Kinase PKR Induces Apoptosis and Fas Receptor Expression

PKR is an interferon-induced dsRNA-dependent protein kinase involved in the antiviral response as well as in cell growth and differentiation. Studies using a transdominant negative mutant of PKR also have implicated the kinase in tumor suppression and apoptosis. However, functional studies of PKR ha...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1999-04, Vol.256 (2), p.322-329
Hauptverfasser:	Donzé, Olivier, Dostie, Josée, Sonenberg, Nahum
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Apoptosis Cell Division eIF-2 Kinase - genetics eIF-2 Kinase - metabolism fas Receptor - genetics Gene Expression Regulation - drug effects Humans Interferons Mice RNA, Double-Stranded Tetracycline - pharmacology
Online-Zugang:	Volltext
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