Role of TLR9 in hepatic stellate cells and experimental liver fibrosis

Accumulating evidence indicates that bacteria and bacterial products promote hepatic fibrogenesis. The activation of hepatic stellate cells (HSC) plays a central role in hepatic fibrosis. Here, we demonstrate that HSC express toll-like receptor 9 (TLR9), a pattern recognition receptor that is activa...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-11, Vol.376 (2), p.271-276
Hauptverfasser:	Gäbele, Erwin, Mühlbauer, Marcus, Dorn, Christoph, Weiss, Thomas S., Froh, Matthias, Schnabl, Bernd, Wiest, Reiner, Schölmerich, Jürgen, Obermeier, Florian, Hellerbrand, Claus
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Bacterial DNA Chemokine CCL2 - genetics CpG Islands - immunology CpG motifs DNA, Bacterial - immunology Hepatic fibrosis Hepatic stellate cell Humans Liver - immunology Liver - pathology Liver Cirrhosis - immunology Liver Cirrhosis - pathology Mice Mice, Mutant Strains Models, Animal TLR9 Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - immunology
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