Brain white matter damage in SCA1 and SCA2. An in vivo study using voxel-based morphometry, histogram analysis of mean diffusivity and tract-based spatial statistics

Neurodegeneration in spinocerebellar ataxia type 1(SCA1) and 2(SCA2) is associated with white matter(WM) damage. Voxel-Based Morphometry(VBM), histogram analysis of mean diffusivity(MD) and Tract-Based Spatial Statistics(TBSS) enable an in vivo quantitative analysis of WM volume and structure. We as...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2008-10, Vol.43 (1), p.10-19
Hauptverfasser:	Nave, Riccardo Della, Ginestroni, Andrea, Tessa, Carlo, Salvatore, Elena, De Grandis, Domenico, Plasmati, Rosaria, Salvi, Fabrizio, De Michele, Giuseppe, Dotti, Maria Teresa, Piacentini, Silvia, Mascalchi, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Ataxia Ataxin-1 Ataxins Brain Brain Stem - metabolism Brain Stem - pathology Cerebellum - metabolism Cerebellum - pathology Data Interpretation, Statistical Data processing Diffusion Magnetic Resonance Imaging - methods Female Humans Male Middle Aged Nerve Fibers, Myelinated - metabolism Nerve Fibers, Myelinated - pathology Nerve Tissue Proteins - metabolism Nuclear Proteins - metabolism Olivopontocerebellar atrophy Software Spinocerebellar ataxia type 1 Spinocerebellar ataxia type 2 Spinocerebellar Ataxias - metabolism Spinocerebellar Ataxias - pathology Statistics Tissue Distribution Tract-based spatial statistics-MR imaging Voxel-based morphometry
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