A novel endothelial-derived lipase that modulates HDL metabolism

High-density lipoprotein (HDL) cholesterol levels are inversely associated with risk of atherosclerotic cardiovascular disease 1 . At least 50% of the variation in HDL cholesterol levels is genetically determined 2 , 3 , but the genes responsible for variation in HDL levels have not been fully eluci...

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Veröffentlicht in:	Nature genetics 1999-04, Vol.21 (4), p.424-428
Hauptverfasser:	Rader, Daniel J, Jaye, Michael, Lynch, Kevin J, Krawiec, John, Marchadier, Dawn, Maugeais, Cyrille, Doan, Kim, South, Victoria, Amin, Dilip, Perrone, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino Acid Sequence Animal Genetics and Genomics Animals Anticholesteremic Agents - pharmacology Apolipoprotein A-I - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Northern Cancer Research Cells, Cultured Cholesterol, HDL - blood Cholesterol, HDL - drug effects Classical genetics, quantitative genetics, hybrids Cloning, Molecular COS Cells - enzymology Endothelium, Vascular - cytology Endothelium, Vascular - enzymology Female Fundamental and applied biological sciences. Psychology Gene Function Genetics of eukaryotes. Biological and molecular evolution Human Human Genetics Humans letter Lipase - genetics Lipase - metabolism Lipoproteins, HDL - blood Lipoproteins, HDL - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Molecular Sequence Data Placenta Pregnancy Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Sequence Homology, Amino Acid Transfection
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