Central vasopressin is modulated by chronic blockade of the renin-angiotensin system in experimental left ventricular hypertrophy
We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the...
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| Veröffentlicht in: | American journal of hypertension 1999-03, Vol.12 (3), p.311-314 |
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| creator | Muders, Frank Elsner, Dietmar Schunkert, Heribert Riegger, Günter A.J Palkovits, Miklos |
| description | We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the RAS by angiotensin-converting enzyme (ACE) inhibition (ramipril) and AT
1 receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT
1 antagonists. |
| doi_str_mv | 10.1016/S0895-7061(98)00177-0 |
| format | Article |
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1 receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT
1 antagonists.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/S0895-7061(98)00177-0</identifier><identifier>PMID: 10192235</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>angiotensin II ; angiotensin-converting enzyme ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Animals ; aortic banding ; Biological and medical sciences ; Blood Pressure ; Brain Chemistry - drug effects ; brain nuclei ; Cardiology. Vascular system ; Heart ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Hypertrophy, Left Ventricular - metabolism ; Hypertrophy, Left Ventricular - physiopathology ; Losartan - pharmacology ; Medical sciences ; Ramipril - pharmacology ; Rats ; Rats, Wistar ; Renin-Angiotensin System - drug effects ; Vasopressin ; Vasopressins - blood ; ventricular hypertrophy</subject><ispartof>American journal of hypertension, 1999-03, Vol.12 (3), p.311-314</ispartof><rights>1999 American Journal of Hypertension, Ltd.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-8d552a9ca85d0b3fd64b4072cd843d7dca444693b344fdb9bed7c3b3f60ae2d13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1744516$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10192235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muders, Frank</creatorcontrib><creatorcontrib>Elsner, Dietmar</creatorcontrib><creatorcontrib>Schunkert, Heribert</creatorcontrib><creatorcontrib>Riegger, Günter A.J</creatorcontrib><creatorcontrib>Palkovits, Miklos</creatorcontrib><title>Central vasopressin is modulated by chronic blockade of the renin-angiotensin system in experimental left ventricular hypertrophy</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the RAS by angiotensin-converting enzyme (ACE) inhibition (ramipril) and AT
1 receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT
1 antagonists.</description><subject>angiotensin II</subject><subject>angiotensin-converting enzyme</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Animals</subject><subject>aortic banding</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Brain Chemistry - drug effects</subject><subject>brain nuclei</subject><subject>Cardiology. Vascular system</subject><subject>Heart</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Hypertrophy, Left Ventricular - metabolism</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Losartan - pharmacology</subject><subject>Medical sciences</subject><subject>Ramipril - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>Vasopressin</subject><subject>Vasopressins - blood</subject><subject>ventricular hypertrophy</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhiMEokvhJwA-IASHgJ34Iz5VaAUUafmQAAlxsRx7Qtxm7cX2rrpH_jneZtVy42Rb88w7nqeqHhP8imDCX3_FnWS1wJy8kN1LjIkQNb5TLUgnZE0kZnerxQ1yUj1I6QJjTDkn96uTkiCbpmWL6s8SfI56QjudwiZCSs4jl9A62O2kM1jU75EZY_DOoH4K5lJbQGFAeQQUwTtfa__LhQz-0Jn2KcMalRtcbSC6dUkv4RMMGe0Ok5wpsRGN-1LNMWzG_cPq3qCnBI-O52n1_d3bb8vzevX5_Yflm1VtmKS57ixjjZZGd8zivh0spz3FojG2o60V1mhKKZdt31I62F72YIUpr4FjDY0l7Wn1fM7dxPB7CymrtUsGpkl7CNukuOS8k1wUkM2giSGlCIPalEV03CuC1cG9unavDmKV7NS1e4VL35PjgG2_BvtP1yy7AM-OgE5GT0PU3rh0ywlKGeEFezpjXudthJu6vhiJlJK1hahnwhXbV7dAvFTl_4Kp8x8_1ZePqxVvl0J9KvzZzEPxu3MQVTIOvAHrIpisbHD_2e0vpIy-ew</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Muders, Frank</creator><creator>Elsner, Dietmar</creator><creator>Schunkert, Heribert</creator><creator>Riegger, Günter A.J</creator><creator>Palkovits, Miklos</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Central vasopressin is modulated by chronic blockade of the renin-angiotensin system in experimental left ventricular hypertrophy</title><author>Muders, Frank ; Elsner, Dietmar ; Schunkert, Heribert ; Riegger, Günter A.J ; Palkovits, Miklos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-8d552a9ca85d0b3fd64b4072cd843d7dca444693b344fdb9bed7c3b3f60ae2d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>angiotensin II</topic><topic>angiotensin-converting enzyme</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Animals</topic><topic>aortic banding</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Brain Chemistry - drug effects</topic><topic>brain nuclei</topic><topic>Cardiology. Vascular system</topic><topic>Heart</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Hypertrophy, Left Ventricular - metabolism</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Losartan - pharmacology</topic><topic>Medical sciences</topic><topic>Ramipril - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>Vasopressin</topic><topic>Vasopressins - blood</topic><topic>ventricular hypertrophy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muders, Frank</creatorcontrib><creatorcontrib>Elsner, Dietmar</creatorcontrib><creatorcontrib>Schunkert, Heribert</creatorcontrib><creatorcontrib>Riegger, Günter A.J</creatorcontrib><creatorcontrib>Palkovits, Miklos</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muders, Frank</au><au>Elsner, Dietmar</au><au>Schunkert, Heribert</au><au>Riegger, Günter A.J</au><au>Palkovits, Miklos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central vasopressin is modulated by chronic blockade of the renin-angiotensin system in experimental left ventricular hypertrophy</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>12</volume><issue>3</issue><spage>311</spage><epage>314</epage><pages>311-314</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><abstract>We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the RAS by angiotensin-converting enzyme (ACE) inhibition (ramipril) and AT
1 receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT
1 antagonists.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10192235</pmid><doi>10.1016/S0895-7061(98)00177-0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | angiotensin II angiotensin-converting enzyme Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals aortic banding Biological and medical sciences Blood Pressure Brain Chemistry - drug effects brain nuclei Cardiology. Vascular system Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hypertrophy, Left Ventricular - metabolism Hypertrophy, Left Ventricular - physiopathology Losartan - pharmacology Medical sciences Ramipril - pharmacology Rats Rats, Wistar Renin-Angiotensin System - drug effects Vasopressin Vasopressins - blood ventricular hypertrophy |
| title | Central vasopressin is modulated by chronic blockade of the renin-angiotensin system in experimental left ventricular hypertrophy |
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