Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice

Neovascularization within the intima of human atherosclerotic lesions is well described, but its role in the progression of atherosclerosis is unknown. In this report, we first demonstrate that intimal vessels occur in advanced lesions of apolipoprotein E-deficient (apoE -/-) mice. To test the hypot...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1999-04, Vol.99 (13), p.1726-1732
Hauptverfasser:	MOULTON, K. S, HELLER, E, KONERDING, M. A, FLYNN, E, PALINSKI, W, FOLKMAN, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - drug effects Aorta, Thoracic - pathology Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Count - drug effects Cell Division - drug effects Collagen - pharmacology Cyclohexanes Endostatins Male Medical sciences Mice Mice, Knockout Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Neovascularization, Pathologic - pathology O-(Chloroacetylcarbamoyl)fumagillol Peptide Fragments - pharmacology Sesquiterpenes - pharmacology Time Factors Tunica Intima - drug effects Tunica Intima - pathology
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