Regulation of cell adhesion by PAI-1
Type I plasminogen activator inhibitor (PAI‐1) is the primary inhibitor of tissue‐and urokinase‐type plasminogen activators. It circulates in plasma complexed with vitronectin (VN), the primary PAI‐1 binding protein. The somatomedin B (SMB) domain of VN contains both the high affinity PAI‐1 binding...
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| Veröffentlicht in: | APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 1999-03, Vol.107 (1-6), p.54-61 |
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| container_end_page | 61 |
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| container_issue | 1-6 |
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| container_title | APMIS : acta pathologica, microbiologica et immunologica Scandinavica |
| container_volume | 107 |
| creator | LOSKUTOFF, DAVID J. CURRIDEN, SCOTT A. HU, GENG DENG, GANG |
| description | Type I plasminogen activator inhibitor (PAI‐1) is the primary inhibitor of tissue‐and urokinase‐type plasminogen activators. It circulates in plasma complexed with vitronectin (VN), the primary PAI‐1 binding protein. The somatomedin B (SMB) domain of VN contains both the high affinity PAI‐1 binding site and the specific site for urokinase plasminogen activator receptor (uPAR). PAI‐1 is able to regulate uPAR‐mediated cell adhesion by competing with uPAR for VN binding. Binding of PAI‐1 to SMD may also affect integrin‐mediated cell adhesion to VN by hindering integrin binding to the RGD sequence adjacent to the uPAR binding site. |
| doi_str_mv | 10.1111/j.1699-0463.1999.tb01526.x |
| format | Article |
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It circulates in plasma complexed with vitronectin (VN), the primary PAI‐1 binding protein. The somatomedin B (SMB) domain of VN contains both the high affinity PAI‐1 binding site and the specific site for urokinase plasminogen activator receptor (uPAR). PAI‐1 is able to regulate uPAR‐mediated cell adhesion by competing with uPAR for VN binding. Binding of PAI‐1 to SMD may also affect integrin‐mediated cell adhesion to VN by hindering integrin binding to the RGD sequence adjacent to the uPAR binding site.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Cell Adhesion</subject><subject>Humans</subject><subject>integrins</subject><subject>Plasminogen Activator Inhibitor 1 - physiology</subject><subject>Receptors, Cell Surface - physiology</subject><subject>Receptors, Urokinase Plasminogen Activator</subject><subject>Type I plasminogen activator inhibitor (PAI-1)</subject><subject>urokinase plasminogen activator receptor (uPAR)</subject><subject>vitronectin (VN)</subject><subject>Vitronectin - physiology</subject><issn>0903-4641</issn><issn>1600-0463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFFLwzAQx4Mobk6_ghQR31rvmjRpBB_G0DmYOoYy8SWkXaqd3TqbFrdvb2uH-Oq9HFz-v7vwI-QMwcO6LhcecildYJx6KKX0yggw8Lm32SNd5AA_T_ukCxKoyzjDDjmydgGAfsjFIekgoAQ_hC45n5q3KtNlmq-cPHFik2WOnr8b2wyirTPpj1w8JgeJzqw52fUeeb69eRrcuePH4WjQH7sxE5S5CJGOBUhJkcb1SLPIMCmomAfIMQQWJkwaTHgomYwoJIlPpdFByCiDyHDaIxft3nWRf1bGlmqZ2uZLemXyyiouOReC0jp41QbjIre2MIlaF-lSF1uFoBpHaqEaR6oRoRpHaudIbWr4dHelipZm_gdtpdSB6zbwlWZm-4_Vqj-5D1jNuy2f2tJsfnldfChe2wjU7GGoBISvM86m6oV-A_NkghE</recordid><startdate>199903</startdate><enddate>199903</enddate><creator>LOSKUTOFF, DAVID J.</creator><creator>CURRIDEN, SCOTT A.</creator><creator>HU, GENG</creator><creator>DENG, GANG</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199903</creationdate><title>Regulation of cell adhesion by PAI-1</title><author>LOSKUTOFF, DAVID J. ; CURRIDEN, SCOTT A. ; HU, GENG ; DENG, GANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4734-10bac7099313cc47a4be49737d51618048f49e1f68949b30ff239ea584340be63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Cell Adhesion</topic><topic>Humans</topic><topic>integrins</topic><topic>Plasminogen Activator Inhibitor 1 - physiology</topic><topic>Receptors, Cell Surface - physiology</topic><topic>Receptors, Urokinase Plasminogen Activator</topic><topic>Type I plasminogen activator inhibitor (PAI-1)</topic><topic>urokinase plasminogen activator receptor (uPAR)</topic><topic>vitronectin (VN)</topic><topic>Vitronectin - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LOSKUTOFF, DAVID J.</creatorcontrib><creatorcontrib>CURRIDEN, SCOTT A.</creatorcontrib><creatorcontrib>HU, GENG</creatorcontrib><creatorcontrib>DENG, GANG</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LOSKUTOFF, DAVID J.</au><au>CURRIDEN, SCOTT A.</au><au>HU, GENG</au><au>DENG, GANG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of cell adhesion by PAI-1</atitle><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle><addtitle>APMIS</addtitle><date>1999-03</date><risdate>1999</risdate><volume>107</volume><issue>1-6</issue><spage>54</spage><epage>61</epage><pages>54-61</pages><issn>0903-4641</issn><eissn>1600-0463</eissn><abstract>Type I plasminogen activator inhibitor (PAI‐1) is the primary inhibitor of tissue‐and urokinase‐type plasminogen activators. 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| fulltext | fulltext |
| identifier | ISSN: 0903-4641 |
| ispartof | APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 1999-03, Vol.107 (1-6), p.54-61 |
| issn | 0903-4641 1600-0463 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Animals Binding Sites Cell Adhesion Humans integrins Plasminogen Activator Inhibitor 1 - physiology Receptors, Cell Surface - physiology Receptors, Urokinase Plasminogen Activator Type I plasminogen activator inhibitor (PAI-1) urokinase plasminogen activator receptor (uPAR) vitronectin (VN) Vitronectin - physiology |
| title | Regulation of cell adhesion by PAI-1 |
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