Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer
Cervical cancer is the second most frequent cancer among women worldwide and the most frequent cancer among women in Africa, Asia, and South America. 1 In the United States, where screening for cervical cancer is readily available, most women who are found to have cervical cancer were not screened r...
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| Veröffentlicht in: | The New England journal of medicine 1999-04, Vol.340 (15), p.1144-1153 |
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| container_title | The New England journal of medicine |
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| creator | Rose, Peter G Bundy, Brian N Watkins, Edwin B Thigpen, J. Tate Deppe, Gunther Maiman, Mitchell A Clarke-Pearson, Daniel L Insalaco, Sam |
| description | Cervical cancer is the second most frequent cancer among women worldwide and the most frequent cancer among women in Africa, Asia, and South America.
1
In the United States, where screening for cervical cancer is readily available, most women who are found to have cervical cancer were not screened regularly.
2
As a result, about 25 percent of patients with cervical cancer in the United States present with locally advanced disease (stage IIB through IVA according to the staging system of the International Federation of Gynecology and Obstetrics).
3
,
4
The ability of radiotherapy to cure locally advanced cervical cancer is limited by . . . |
| doi_str_mv | 10.1056/NEJM199904153401502 |
| format | Article |
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1
In the United States, where screening for cervical cancer is readily available, most women who are found to have cervical cancer were not screened regularly.
2
As a result, about 25 percent of patients with cervical cancer in the United States present with locally advanced disease (stage IIB through IVA according to the staging system of the International Federation of Gynecology and Obstetrics).
3
,
4
The ability of radiotherapy to cure locally advanced cervical cancer is limited by . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199904153401502</identifier><identifier>PMID: 10202165</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Antineoplastic Agents - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Brachytherapy ; Cancer therapies ; Carcinoma - drug therapy ; Carcinoma - pathology ; Carcinoma - radiotherapy ; Cell cycle ; Cervical cancer ; Chemotherapy ; Cisplatin - therapeutic use ; Combined Modality Therapy - adverse effects ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Disease Progression ; Female ; Fluorouracil - therapeutic use ; Humans ; Hydroxyurea - therapeutic use ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Ovarian cancer ; Pharmacology. Drug treatments ; Radiation therapy ; Survival Analysis ; Uterine Cervical Neoplasms - drug therapy ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - radiotherapy ; Womens health</subject><ispartof>The New England journal of medicine, 1999-04, Vol.340 (15), p.1144-1153</ispartof><rights>Copyright © 1999 Massachusetts Medical Society. All rights reserved.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c645t-8af4c25b199ecf37e7d3341c7f6febb39b35d6c0d33674feaa4f2a7eddc41e0d3</citedby><cites>FETCH-LOGICAL-c645t-8af4c25b199ecf37e7d3341c7f6febb39b35d6c0d33674feaa4f2a7eddc41e0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199904153401502$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199904153401502$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1762015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10202165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rose, Peter G</creatorcontrib><creatorcontrib>Bundy, Brian N</creatorcontrib><creatorcontrib>Watkins, Edwin B</creatorcontrib><creatorcontrib>Thigpen, J. Tate</creatorcontrib><creatorcontrib>Deppe, Gunther</creatorcontrib><creatorcontrib>Maiman, Mitchell A</creatorcontrib><creatorcontrib>Clarke-Pearson, Daniel L</creatorcontrib><creatorcontrib>Insalaco, Sam</creatorcontrib><title>Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Cervical cancer is the second most frequent cancer among women worldwide and the most frequent cancer among women in Africa, Asia, and South America.
1
In the United States, where screening for cervical cancer is readily available, most women who are found to have cervical cancer were not screened regularly.
2
As a result, about 25 percent of patients with cervical cancer in the United States present with locally advanced disease (stage IIB through IVA according to the staging system of the International Federation of Gynecology and Obstetrics).
3
,
4
The ability of radiotherapy to cure locally advanced cervical cancer is limited by . . .</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brachytherapy</subject><subject>Cancer therapies</subject><subject>Carcinoma - drug therapy</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - radiotherapy</subject><subject>Cell cycle</subject><subject>Cervical cancer</subject><subject>Chemotherapy</subject><subject>Cisplatin - therapeutic use</subject><subject>Combined Modality Therapy - adverse effects</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fluorouracil - therapeutic use</subject><subject>Humans</subject><subject>Hydroxyurea - therapeutic use</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Ovarian cancer</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiation therapy</subject><subject>Survival Analysis</subject><subject>Uterine Cervical Neoplasms - drug therapy</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><subject>Womens health</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kFlLxDAUhYMoOi6_QJAi4otUszWZPI7FlVFB9FFKmtxghy5j0grz743MoCJiXpIcvnNuchDaJ_iU4Eyc3V_c3hGlFOYkYxyTDNM1NIpnlnKOxToaYUzHKZeKbaHtEGY4LsLVJtoimGJKRDZCL3nXmsF7aPskr8K81n3Vpuc6gE0eta26_hW8ni8S3dokf4XmS3CdT6ad0XW9SCb2XbcmWnLw71XUkvzz7nfRhtN1gL3VvoOeLy-e8ut0-nB1k0-mqRE869OxdtzQrIy_AeOYBGkZ48RIJxyUJVMly6wwOKpCcgdac0e1BGsNJxDlHXS8zJ377m2A0BdNFQzUtW6hG0IhlBBSEhnBw1_grBt8G99WUMoUz8ZKRYgtIeO7EDy4Yu6rRvtFQXDxWX3xR_XRdbCKHsoG7A_PsusIHK0AHWJFzseKqvDNSUFjUsROlljThKKFWfPv1A9Hmpgv</recordid><startdate>19990415</startdate><enddate>19990415</enddate><creator>Rose, Peter G</creator><creator>Bundy, Brian N</creator><creator>Watkins, Edwin B</creator><creator>Thigpen, J. Tate</creator><creator>Deppe, Gunther</creator><creator>Maiman, Mitchell A</creator><creator>Clarke-Pearson, Daniel L</creator><creator>Insalaco, Sam</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19990415</creationdate><title>Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer</title><author>Rose, Peter G ; Bundy, Brian N ; Watkins, Edwin B ; Thigpen, J. 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Tate</au><au>Deppe, Gunther</au><au>Maiman, Mitchell A</au><au>Clarke-Pearson, Daniel L</au><au>Insalaco, Sam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1999-04-15</date><risdate>1999</risdate><volume>340</volume><issue>15</issue><spage>1144</spage><epage>1153</epage><pages>1144-1153</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Cervical cancer is the second most frequent cancer among women worldwide and the most frequent cancer among women in Africa, Asia, and South America.
1
In the United States, where screening for cervical cancer is readily available, most women who are found to have cervical cancer were not screened regularly.
2
As a result, about 25 percent of patients with cervical cancer in the United States present with locally advanced disease (stage IIB through IVA according to the staging system of the International Federation of Gynecology and Obstetrics).
3
,
4
The ability of radiotherapy to cure locally advanced cervical cancer is limited by . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>10202165</pmid><doi>10.1056/NEJM199904153401502</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1999-04, Vol.340 (15), p.1144-1153 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69667717 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adult Aged Antineoplastic agents Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Brachytherapy Cancer therapies Carcinoma - drug therapy Carcinoma - pathology Carcinoma - radiotherapy Cell cycle Cervical cancer Chemotherapy Cisplatin - therapeutic use Combined Modality Therapy - adverse effects Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Disease Progression Female Fluorouracil - therapeutic use Humans Hydroxyurea - therapeutic use Medical sciences Middle Aged Neoplasm Staging Ovarian cancer Pharmacology. Drug treatments Radiation therapy Survival Analysis Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy Womens health |
| title | Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer |
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