Effect of Three Different Intensities of Infrared Laser Energy on the Levels of Amino Acid Neurotransmitters in the Cortex and Hippocampus of Rat Brain
Objective: The aim of this study is to investigate the effects of three different intensities of infrared diode laser radiation on amino acid neurotransmitters in the cortex and hippocampus of rat brain. Background Data: Lasers are known to induce different neurological effects such as pain relief,...
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| Veröffentlicht in: | Photomedicine and laser surgery 2008-10, Vol.26 (5), p.479-488 |
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| container_title | Photomedicine and laser surgery |
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| creator | Ahmed, Nawal Abd El Hay Radwan, Nasr Mahmoud Ibrahim, Khayria Mansour Khedr, Mona Emam El Aziz, Mona A. Khadrawy, Yasser Ashry |
| description | Objective:
The aim of this study is to investigate the effects of three different intensities of infrared diode laser radiation on amino acid neurotransmitters in the cortex and hippocampus of rat brain.
Background Data:
Lasers are known to induce different neurological effects such as pain relief, anesthesia, and neurosuppressive effects; however, the precise mechanisms of these effects are not clearly elucidated. Amino acid neurotransmitters (glutamate, aspartate, glutamine,
γ
-aminobutyric acid [GABA], glycine, and taurine) play vital roles in the central nervous system (CNS).
Materials and Methods:
The shaved scalp of each rat was exposed to different intensities of infrared laser energy (500, 190, and 90 mW) and then the rats were sacrificed after 1 h, 7 d, and 14 d of daily laser irradiation. The control groups were exposed to the same conditions but without exposure to laser. The concentrations of amino acid neurotransmitters were measured by high-performance liquid chromatography (HPLC).
Results:
The rats subjected to 500 mW of laser irradiation had a significant decrease in glutamate, aspartate, and taurine in the cortex, and a significant decrease in hippocampal GABA. In the cortices of rats exposed to 190 mW of laser irradiation, an increase in aspartate accompanied by a decrease in glutamine were observed. In the hippocampus, other changes were seen. The rats irradiated with 90 mW showed a decrease in cortical glutamate, aspartate, and glutamine, and an increase in glycine, while in the hippocampus an increase in glutamate, aspartate, and GABA were recorded.
Conclusion:
We conclude that daily laser irradiation at 90 mW produced the most pronounced inhibitory effect in the cortex after 7 d. This finding may explain the reported neurosuppressive effect of infrared laser energy on axonal conduction of hippocampal and cortical tissues of rat brain. |
| doi_str_mv | 10.1089/pho.2007.2190 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_69667514</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A200117871</galeid><sourcerecordid>A200117871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-46df9a2c8b4d86122610efd85100f9e6903e3aec76c336b2f683f1a13ad6928d3</originalsourceid><addsrcrecordid>eNpt0U1vFCEYB_CJsbG1evRqSEy8mFlhXhg4rutqN9nUxNQzYeGhi5mBERhjP4lfV6azsWnScIA8_B4C_IviDcErghn_OB79qsK4W1WE42fFBWnbrmRti5_P64aXbUPYefEyxp8YV7zj9YvinDCGMW_4RfF3awyohLxBN8cAgD7bXAjgEtq5BC7aZCHO2ztnggyg0V5GCGjrINzeIe9QOgLaw2_o79l6sM6jtbIaXcMUfArSxcGmBCEiu-iNDwn-IOk0urLj6JUcxum--7tM6FOQ1r0qzozsI7w-zZfFjy_bm81Vuf_2dbdZ70tV8yaVDdWGy0qxQ6MZJVVFCQajWUswNhwoxzXUElRHVV3TQ2Uoqw2RpJaa8orp-rJ4v5w7Bv9rgpjEYKOCvpcO_BQF5ZR2LWkyfLfAW9mDsM7ML1MzFuv8_4R0rCNZrZ5QeWgYrPIOjM31Rw3l0qCCjzGAEWOwgwx3gmAxByxywGIOWMwBZ__2dN_pMIB-0KdEM_iwgLksnestHCCk__Dxcf8AZi2wOg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69667514</pqid></control><display><type>article</type><title>Effect of Three Different Intensities of Infrared Laser Energy on the Levels of Amino Acid Neurotransmitters in the Cortex and Hippocampus of Rat Brain</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Ahmed, Nawal Abd El Hay ; Radwan, Nasr Mahmoud ; Ibrahim, Khayria Mansour ; Khedr, Mona Emam ; El Aziz, Mona A. ; Khadrawy, Yasser Ashry</creator><creatorcontrib>Ahmed, Nawal Abd El Hay ; Radwan, Nasr Mahmoud ; Ibrahim, Khayria Mansour ; Khedr, Mona Emam ; El Aziz, Mona A. ; Khadrawy, Yasser Ashry</creatorcontrib><description>Objective:
The aim of this study is to investigate the effects of three different intensities of infrared diode laser radiation on amino acid neurotransmitters in the cortex and hippocampus of rat brain.
Background Data:
Lasers are known to induce different neurological effects such as pain relief, anesthesia, and neurosuppressive effects; however, the precise mechanisms of these effects are not clearly elucidated. Amino acid neurotransmitters (glutamate, aspartate, glutamine,
γ
-aminobutyric acid [GABA], glycine, and taurine) play vital roles in the central nervous system (CNS).
Materials and Methods:
The shaved scalp of each rat was exposed to different intensities of infrared laser energy (500, 190, and 90 mW) and then the rats were sacrificed after 1 h, 7 d, and 14 d of daily laser irradiation. The control groups were exposed to the same conditions but without exposure to laser. The concentrations of amino acid neurotransmitters were measured by high-performance liquid chromatography (HPLC).
Results:
The rats subjected to 500 mW of laser irradiation had a significant decrease in glutamate, aspartate, and taurine in the cortex, and a significant decrease in hippocampal GABA. In the cortices of rats exposed to 190 mW of laser irradiation, an increase in aspartate accompanied by a decrease in glutamine were observed. In the hippocampus, other changes were seen. The rats irradiated with 90 mW showed a decrease in cortical glutamate, aspartate, and glutamine, and an increase in glycine, while in the hippocampus an increase in glutamate, aspartate, and GABA were recorded.
Conclusion:
We conclude that daily laser irradiation at 90 mW produced the most pronounced inhibitory effect in the cortex after 7 d. This finding may explain the reported neurosuppressive effect of infrared laser energy on axonal conduction of hippocampal and cortical tissues of rat brain.</description><identifier>ISSN: 1549-5418</identifier><identifier>EISSN: 1557-8550</identifier><identifier>DOI: 10.1089/pho.2007.2190</identifier><identifier>PMID: 18800949</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Amino Acids - metabolism ; Animals ; Cerebral Cortex - metabolism ; Cerebral Cortex - radiation effects ; Health aspects ; Hippocampus (Brain) ; Hippocampus - metabolism ; Hippocampus - radiation effects ; Infrared Rays ; Lasers in surgery ; Lasers, Semiconductor ; Low-Level Light Therapy ; Neurotransmitter Agents - metabolism ; Physiological aspects ; Rats ; Rattus</subject><ispartof>Photomedicine and laser surgery, 2008-10, Vol.26 (5), p.479-488</ispartof><rights>2008 Mary Ann Liebert, Inc.</rights><rights>COPYRIGHT 2008 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-46df9a2c8b4d86122610efd85100f9e6903e3aec76c336b2f683f1a13ad6928d3</citedby><cites>FETCH-LOGICAL-c394t-46df9a2c8b4d86122610efd85100f9e6903e3aec76c336b2f683f1a13ad6928d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18800949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Nawal Abd El Hay</creatorcontrib><creatorcontrib>Radwan, Nasr Mahmoud</creatorcontrib><creatorcontrib>Ibrahim, Khayria Mansour</creatorcontrib><creatorcontrib>Khedr, Mona Emam</creatorcontrib><creatorcontrib>El Aziz, Mona A.</creatorcontrib><creatorcontrib>Khadrawy, Yasser Ashry</creatorcontrib><title>Effect of Three Different Intensities of Infrared Laser Energy on the Levels of Amino Acid Neurotransmitters in the Cortex and Hippocampus of Rat Brain</title><title>Photomedicine and laser surgery</title><addtitle>Photomed Laser Surg</addtitle><description>Objective:
The aim of this study is to investigate the effects of three different intensities of infrared diode laser radiation on amino acid neurotransmitters in the cortex and hippocampus of rat brain.
Background Data:
Lasers are known to induce different neurological effects such as pain relief, anesthesia, and neurosuppressive effects; however, the precise mechanisms of these effects are not clearly elucidated. Amino acid neurotransmitters (glutamate, aspartate, glutamine,
γ
-aminobutyric acid [GABA], glycine, and taurine) play vital roles in the central nervous system (CNS).
Materials and Methods:
The shaved scalp of each rat was exposed to different intensities of infrared laser energy (500, 190, and 90 mW) and then the rats were sacrificed after 1 h, 7 d, and 14 d of daily laser irradiation. The control groups were exposed to the same conditions but without exposure to laser. The concentrations of amino acid neurotransmitters were measured by high-performance liquid chromatography (HPLC).
Results:
The rats subjected to 500 mW of laser irradiation had a significant decrease in glutamate, aspartate, and taurine in the cortex, and a significant decrease in hippocampal GABA. In the cortices of rats exposed to 190 mW of laser irradiation, an increase in aspartate accompanied by a decrease in glutamine were observed. In the hippocampus, other changes were seen. The rats irradiated with 90 mW showed a decrease in cortical glutamate, aspartate, and glutamine, and an increase in glycine, while in the hippocampus an increase in glutamate, aspartate, and GABA were recorded.
Conclusion:
We conclude that daily laser irradiation at 90 mW produced the most pronounced inhibitory effect in the cortex after 7 d. This finding may explain the reported neurosuppressive effect of infrared laser energy on axonal conduction of hippocampal and cortical tissues of rat brain.</description><subject>Amino Acids - metabolism</subject><subject>Animals</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - radiation effects</subject><subject>Health aspects</subject><subject>Hippocampus (Brain)</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - radiation effects</subject><subject>Infrared Rays</subject><subject>Lasers in surgery</subject><subject>Lasers, Semiconductor</subject><subject>Low-Level Light Therapy</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Physiological aspects</subject><subject>Rats</subject><subject>Rattus</subject><issn>1549-5418</issn><issn>1557-8550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0U1vFCEYB_CJsbG1evRqSEy8mFlhXhg4rutqN9nUxNQzYeGhi5mBERhjP4lfV6azsWnScIA8_B4C_IviDcErghn_OB79qsK4W1WE42fFBWnbrmRti5_P64aXbUPYefEyxp8YV7zj9YvinDCGMW_4RfF3awyohLxBN8cAgD7bXAjgEtq5BC7aZCHO2ztnggyg0V5GCGjrINzeIe9QOgLaw2_o79l6sM6jtbIaXcMUfArSxcGmBCEiu-iNDwn-IOk0urLj6JUcxum--7tM6FOQ1r0qzozsI7w-zZfFjy_bm81Vuf_2dbdZ70tV8yaVDdWGy0qxQ6MZJVVFCQajWUswNhwoxzXUElRHVV3TQ2Uoqw2RpJaa8orp-rJ4v5w7Bv9rgpjEYKOCvpcO_BQF5ZR2LWkyfLfAW9mDsM7ML1MzFuv8_4R0rCNZrZ5QeWgYrPIOjM31Rw3l0qCCjzGAEWOwgwx3gmAxByxywGIOWMwBZ__2dN_pMIB-0KdEM_iwgLksnestHCCk__Dxcf8AZi2wOg</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Ahmed, Nawal Abd El Hay</creator><creator>Radwan, Nasr Mahmoud</creator><creator>Ibrahim, Khayria Mansour</creator><creator>Khedr, Mona Emam</creator><creator>El Aziz, Mona A.</creator><creator>Khadrawy, Yasser Ashry</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Effect of Three Different Intensities of Infrared Laser Energy on the Levels of Amino Acid Neurotransmitters in the Cortex and Hippocampus of Rat Brain</title><author>Ahmed, Nawal Abd El Hay ; Radwan, Nasr Mahmoud ; Ibrahim, Khayria Mansour ; Khedr, Mona Emam ; El Aziz, Mona A. ; Khadrawy, Yasser Ashry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-46df9a2c8b4d86122610efd85100f9e6903e3aec76c336b2f683f1a13ad6928d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Amino Acids - metabolism</topic><topic>Animals</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Cortex - radiation effects</topic><topic>Health aspects</topic><topic>Hippocampus (Brain)</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - radiation effects</topic><topic>Infrared Rays</topic><topic>Lasers in surgery</topic><topic>Lasers, Semiconductor</topic><topic>Low-Level Light Therapy</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>Physiological aspects</topic><topic>Rats</topic><topic>Rattus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Nawal Abd El Hay</creatorcontrib><creatorcontrib>Radwan, Nasr Mahmoud</creatorcontrib><creatorcontrib>Ibrahim, Khayria Mansour</creatorcontrib><creatorcontrib>Khedr, Mona Emam</creatorcontrib><creatorcontrib>El Aziz, Mona A.</creatorcontrib><creatorcontrib>Khadrawy, Yasser Ashry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photomedicine and laser surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Nawal Abd El Hay</au><au>Radwan, Nasr Mahmoud</au><au>Ibrahim, Khayria Mansour</au><au>Khedr, Mona Emam</au><au>El Aziz, Mona A.</au><au>Khadrawy, Yasser Ashry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Three Different Intensities of Infrared Laser Energy on the Levels of Amino Acid Neurotransmitters in the Cortex and Hippocampus of Rat Brain</atitle><jtitle>Photomedicine and laser surgery</jtitle><addtitle>Photomed Laser Surg</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>26</volume><issue>5</issue><spage>479</spage><epage>488</epage><pages>479-488</pages><issn>1549-5418</issn><eissn>1557-8550</eissn><abstract>Objective:
The aim of this study is to investigate the effects of three different intensities of infrared diode laser radiation on amino acid neurotransmitters in the cortex and hippocampus of rat brain.
Background Data:
Lasers are known to induce different neurological effects such as pain relief, anesthesia, and neurosuppressive effects; however, the precise mechanisms of these effects are not clearly elucidated. Amino acid neurotransmitters (glutamate, aspartate, glutamine,
γ
-aminobutyric acid [GABA], glycine, and taurine) play vital roles in the central nervous system (CNS).
Materials and Methods:
The shaved scalp of each rat was exposed to different intensities of infrared laser energy (500, 190, and 90 mW) and then the rats were sacrificed after 1 h, 7 d, and 14 d of daily laser irradiation. The control groups were exposed to the same conditions but without exposure to laser. The concentrations of amino acid neurotransmitters were measured by high-performance liquid chromatography (HPLC).
Results:
The rats subjected to 500 mW of laser irradiation had a significant decrease in glutamate, aspartate, and taurine in the cortex, and a significant decrease in hippocampal GABA. In the cortices of rats exposed to 190 mW of laser irradiation, an increase in aspartate accompanied by a decrease in glutamine were observed. In the hippocampus, other changes were seen. The rats irradiated with 90 mW showed a decrease in cortical glutamate, aspartate, and glutamine, and an increase in glycine, while in the hippocampus an increase in glutamate, aspartate, and GABA were recorded.
Conclusion:
We conclude that daily laser irradiation at 90 mW produced the most pronounced inhibitory effect in the cortex after 7 d. This finding may explain the reported neurosuppressive effect of infrared laser energy on axonal conduction of hippocampal and cortical tissues of rat brain.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>18800949</pmid><doi>10.1089/pho.2007.2190</doi><tpages>10</tpages></addata></record> |
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| ispartof | Photomedicine and laser surgery, 2008-10, Vol.26 (5), p.479-488 |
| issn | 1549-5418 1557-8550 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Amino Acids - metabolism Animals Cerebral Cortex - metabolism Cerebral Cortex - radiation effects Health aspects Hippocampus (Brain) Hippocampus - metabolism Hippocampus - radiation effects Infrared Rays Lasers in surgery Lasers, Semiconductor Low-Level Light Therapy Neurotransmitter Agents - metabolism Physiological aspects Rats Rattus |
| title | Effect of Three Different Intensities of Infrared Laser Energy on the Levels of Amino Acid Neurotransmitters in the Cortex and Hippocampus of Rat Brain |
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