Reductions in brain phosphatidylinositol kinase activities in alzheimer’s disease

Background: Converging lines of evidence suggest that alterations in the intracellular trafficking of the amyloid precursor protein, its derivatives, and other relevant proteins may contribute to the pathophysiology of Alzheimer’s disease (AD). Since phosphatidylinositol (PI) kinase plays a pivotal...

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Veröffentlicht in:	Biological psychiatry (1969) 1999-03, Vol.45 (6), p.731-736
Hauptverfasser:	Zubenko, George S, Stiffler, J.Scott, Hughes, Hugh B, Martinez, A.Julio
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 4-Kinase - analysis 1-Phosphatidylinositol 4-Kinase - metabolism Aged Aged, 80 and over Alzheimer Disease - enzymology Alzheimer’s disease Biological and medical sciences Brain - enzymology Brain Chemistry Culture Techniques Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Male Medical sciences Neurology Phosphatidylinositol 3-Kinases - analysis Phosphatidylinositol 3-Kinases - metabolism phosphatidylinositol kinase protein sorting and trafficking Retrospective Studies
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