Gastric emptying in hyperemesis gravidarum and non‐dyspeptic pregnancy
Background: Emesis and hyperemesis are significant problems associated with early pregnancy. However, gastric emptying of solids has never been studied during early pregnancy in humans. Aim: To investigate gastric emptying of solids in patients recovering from hyperemesis gravidarum and in non‐dyspe...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 1999-02, Vol.13 (2), p.237-243 |
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| creator | MAES, B. D SPITZ, B GHOOS, Y. F HIELE, M. I EVENEPOEL, P RUTGEERTS, P. J |
| description | Background:
Emesis and hyperemesis are significant problems associated with early pregnancy. However, gastric emptying of solids has never been studied during early pregnancy in humans.
Aim:
To investigate gastric emptying of solids in patients recovering from hyperemesis gravidarum and in non‐dyspeptic pregnant women and to compare these results with a group of healthy non‐pregnant women.
Methods:
Fourteen patients with hyperemesis gravidarum, 10 non‐dyspeptic pregnant women and 36 non‐pregnant women in the first half of the menstrual cycle underwent a gastric emptying study. Seven non‐pregnant women repeated the test in the post‐ovulatory period.
Results:
Gastric emptying of solids was not significantly delayed in non‐dyspeptic pregnant women compared with non‐pregnant women. The emptying rate tended to be impaired in the post‐ovulatory period of the menstrual cycle. Solid emptying was significantly accelerated in patients recovering from hyperemesis gravidarum, correlating well with thyroid function in the latter group.
Conclusion:
Pregnancy in humans is not associated with decreased solid gastric emptying. In subjects recovering from hyperemesis gravidarum, solid emptying is increased, correlating well with thyroid function abnormalities. Nausea and vomiting in hyperemesis are therefore probably not due to upper gastrointestinal disorders. |
| doi_str_mv | 10.1046/j.1365-2036.1999.00446.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69666493</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69666493</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3936-62ac11fe269069e06a276a4998b87abbfce7f335fa7512275a1cf3ccf42f11143</originalsourceid><addsrcrecordid>eNqNkEtOwzAQhi0EoqVwBZQFYpfgR-LEEpuqghapEizK2nIcu7jKCzuFZscROCMnIWkqYMlqRprvnxl9AHgIBgiG9GYTIEIjH0NCA8QYCyAMQxrsjsD4Z3AMxhBT5uMEkRE4c24DIaQxxKdghCCCmEXRGCzmwjXWSE8VddOacu2Z0ntpa2VVoZxx3tqKN5MJuy08UWZeWZVfH59Z62pVN12stmpdilK25-BEi9ypi0OdgOf7u9Vs4S8f5w-z6dKXhBHqUywkQlp1n0HKFKQCx1SEjCVpEos01VLFmpBIizhCGMeRQFITKXWINUIoJBNwPeytbfW6Va7hhXFS5bkoVbV1nDJKachIByYDKG3lnFWa19YUwrYcQd5b5Bvey-K9LN5b5HuLfNdFLw83tmmhsj_BQVsHXB0A4aTIte0MGPfLURai_Qu3A_ZuctX--z6fPq26hnwDg6qOkA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69666493</pqid></control><display><type>article</type><title>Gastric emptying in hyperemesis gravidarum and non‐dyspeptic pregnancy</title><source>MEDLINE</source><source>Wiley Free Content</source><source>IngentaConnect Free/Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><creator>MAES, B. D ; SPITZ, B ; GHOOS, Y. F ; HIELE, M. I ; EVENEPOEL, P ; RUTGEERTS, P. J</creator><creatorcontrib>MAES, B. D ; SPITZ, B ; GHOOS, Y. F ; HIELE, M. I ; EVENEPOEL, P ; RUTGEERTS, P. J</creatorcontrib><description>Background:
Emesis and hyperemesis are significant problems associated with early pregnancy. However, gastric emptying of solids has never been studied during early pregnancy in humans.
Aim:
To investigate gastric emptying of solids in patients recovering from hyperemesis gravidarum and in non‐dyspeptic pregnant women and to compare these results with a group of healthy non‐pregnant women.
Methods:
Fourteen patients with hyperemesis gravidarum, 10 non‐dyspeptic pregnant women and 36 non‐pregnant women in the first half of the menstrual cycle underwent a gastric emptying study. Seven non‐pregnant women repeated the test in the post‐ovulatory period.
Results:
Gastric emptying of solids was not significantly delayed in non‐dyspeptic pregnant women compared with non‐pregnant women. The emptying rate tended to be impaired in the post‐ovulatory period of the menstrual cycle. Solid emptying was significantly accelerated in patients recovering from hyperemesis gravidarum, correlating well with thyroid function in the latter group.
Conclusion:
Pregnancy in humans is not associated with decreased solid gastric emptying. In subjects recovering from hyperemesis gravidarum, solid emptying is increased, correlating well with thyroid function abnormalities. Nausea and vomiting in hyperemesis are therefore probably not due to upper gastrointestinal disorders.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1046/j.1365-2036.1999.00446.x</identifier><identifier>PMID: 10102955</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Carbon Dioxide - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Gastric Emptying ; Humans ; Hyperemesis Gravidarum - physiopathology ; Middle Aged ; Mother. Fetoplacental unit. Mammary gland. Milk ; Pregnancy - physiology ; Pregnancy. Parturition. Lactation ; Vertebrates: reproduction</subject><ispartof>Alimentary pharmacology & therapeutics, 1999-02, Vol.13 (2), p.237-243</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3936-62ac11fe269069e06a276a4998b87abbfce7f335fa7512275a1cf3ccf42f11143</citedby><cites>FETCH-LOGICAL-c3936-62ac11fe269069e06a276a4998b87abbfce7f335fa7512275a1cf3ccf42f11143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2036.1999.00446.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2036.1999.00446.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1694193$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10102955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAES, B. D</creatorcontrib><creatorcontrib>SPITZ, B</creatorcontrib><creatorcontrib>GHOOS, Y. F</creatorcontrib><creatorcontrib>HIELE, M. I</creatorcontrib><creatorcontrib>EVENEPOEL, P</creatorcontrib><creatorcontrib>RUTGEERTS, P. J</creatorcontrib><title>Gastric emptying in hyperemesis gravidarum and non‐dyspeptic pregnancy</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Background:
Emesis and hyperemesis are significant problems associated with early pregnancy. However, gastric emptying of solids has never been studied during early pregnancy in humans.
Aim:
To investigate gastric emptying of solids in patients recovering from hyperemesis gravidarum and in non‐dyspeptic pregnant women and to compare these results with a group of healthy non‐pregnant women.
Methods:
Fourteen patients with hyperemesis gravidarum, 10 non‐dyspeptic pregnant women and 36 non‐pregnant women in the first half of the menstrual cycle underwent a gastric emptying study. Seven non‐pregnant women repeated the test in the post‐ovulatory period.
Results:
Gastric emptying of solids was not significantly delayed in non‐dyspeptic pregnant women compared with non‐pregnant women. The emptying rate tended to be impaired in the post‐ovulatory period of the menstrual cycle. Solid emptying was significantly accelerated in patients recovering from hyperemesis gravidarum, correlating well with thyroid function in the latter group.
Conclusion:
Pregnancy in humans is not associated with decreased solid gastric emptying. In subjects recovering from hyperemesis gravidarum, solid emptying is increased, correlating well with thyroid function abnormalities. Nausea and vomiting in hyperemesis are therefore probably not due to upper gastrointestinal disorders.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric Emptying</subject><subject>Humans</subject><subject>Hyperemesis Gravidarum - physiopathology</subject><subject>Middle Aged</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Pregnancy - physiology</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Vertebrates: reproduction</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtOwzAQhi0EoqVwBZQFYpfgR-LEEpuqghapEizK2nIcu7jKCzuFZscROCMnIWkqYMlqRprvnxl9AHgIBgiG9GYTIEIjH0NCA8QYCyAMQxrsjsD4Z3AMxhBT5uMEkRE4c24DIaQxxKdghCCCmEXRGCzmwjXWSE8VddOacu2Z0ntpa2VVoZxx3tqKN5MJuy08UWZeWZVfH59Z62pVN12stmpdilK25-BEi9ypi0OdgOf7u9Vs4S8f5w-z6dKXhBHqUywkQlp1n0HKFKQCx1SEjCVpEos01VLFmpBIizhCGMeRQFITKXWINUIoJBNwPeytbfW6Va7hhXFS5bkoVbV1nDJKachIByYDKG3lnFWa19YUwrYcQd5b5Bvey-K9LN5b5HuLfNdFLw83tmmhsj_BQVsHXB0A4aTIte0MGPfLURai_Qu3A_ZuctX--z6fPq26hnwDg6qOkA</recordid><startdate>199902</startdate><enddate>199902</enddate><creator>MAES, B. D</creator><creator>SPITZ, B</creator><creator>GHOOS, Y. F</creator><creator>HIELE, M. I</creator><creator>EVENEPOEL, P</creator><creator>RUTGEERTS, P. J</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199902</creationdate><title>Gastric emptying in hyperemesis gravidarum and non‐dyspeptic pregnancy</title><author>MAES, B. D ; SPITZ, B ; GHOOS, Y. F ; HIELE, M. I ; EVENEPOEL, P ; RUTGEERTS, P. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3936-62ac11fe269069e06a276a4998b87abbfce7f335fa7512275a1cf3ccf42f11143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric Emptying</topic><topic>Humans</topic><topic>Hyperemesis Gravidarum - physiopathology</topic><topic>Middle Aged</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Pregnancy - physiology</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAES, B. D</creatorcontrib><creatorcontrib>SPITZ, B</creatorcontrib><creatorcontrib>GHOOS, Y. F</creatorcontrib><creatorcontrib>HIELE, M. I</creatorcontrib><creatorcontrib>EVENEPOEL, P</creatorcontrib><creatorcontrib>RUTGEERTS, P. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAES, B. D</au><au>SPITZ, B</au><au>GHOOS, Y. F</au><au>HIELE, M. I</au><au>EVENEPOEL, P</au><au>RUTGEERTS, P. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric emptying in hyperemesis gravidarum and non‐dyspeptic pregnancy</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>1999-02</date><risdate>1999</risdate><volume>13</volume><issue>2</issue><spage>237</spage><epage>243</epage><pages>237-243</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Background:
Emesis and hyperemesis are significant problems associated with early pregnancy. However, gastric emptying of solids has never been studied during early pregnancy in humans.
Aim:
To investigate gastric emptying of solids in patients recovering from hyperemesis gravidarum and in non‐dyspeptic pregnant women and to compare these results with a group of healthy non‐pregnant women.
Methods:
Fourteen patients with hyperemesis gravidarum, 10 non‐dyspeptic pregnant women and 36 non‐pregnant women in the first half of the menstrual cycle underwent a gastric emptying study. Seven non‐pregnant women repeated the test in the post‐ovulatory period.
Results:
Gastric emptying of solids was not significantly delayed in non‐dyspeptic pregnant women compared with non‐pregnant women. The emptying rate tended to be impaired in the post‐ovulatory period of the menstrual cycle. Solid emptying was significantly accelerated in patients recovering from hyperemesis gravidarum, correlating well with thyroid function in the latter group.
Conclusion:
Pregnancy in humans is not associated with decreased solid gastric emptying. In subjects recovering from hyperemesis gravidarum, solid emptying is increased, correlating well with thyroid function abnormalities. Nausea and vomiting in hyperemesis are therefore probably not due to upper gastrointestinal disorders.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>10102955</pmid><doi>10.1046/j.1365-2036.1999.00446.x</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 1999-02, Vol.13 (2), p.237-243 |
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| language | eng |
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| source | MEDLINE; Wiley Free Content; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals |
| subjects | Adolescent Adult Biological and medical sciences Carbon Dioxide - metabolism Female Fundamental and applied biological sciences. Psychology Gastric Emptying Humans Hyperemesis Gravidarum - physiopathology Middle Aged Mother. Fetoplacental unit. Mammary gland. Milk Pregnancy - physiology Pregnancy. Parturition. Lactation Vertebrates: reproduction |
| title | Gastric emptying in hyperemesis gravidarum and non‐dyspeptic pregnancy |
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