Timing of coronary stent thrombosis in patients treated with ticlopidine and aspirin
In patients receiving coronary stents treated with aspirin and coumadin, the peak incidence of stent thrombosis occurs on the fifth and sixth days following the implantation procedure. Little is known about the timing of stent thrombosis in patients treated with aspirin and ticlopidine. We compared...
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| Veröffentlicht in: | The American journal of cardiology 1999-04, Vol.83 (7), p.1006-1011 |
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| creator | Wilson, Stephanie H Rihal, Charanjit S Bell, Malcolm R Velianou, James L Holmes, David R Berger, Peter B |
| description | In patients receiving coronary stents treated with aspirin and coumadin, the peak incidence of stent thrombosis occurs on the fifth and sixth days following the implantation procedure. Little is known about the timing of stent thrombosis in patients treated with aspirin and ticlopidine. We compared the timing of coronary stent thrombosis in patients treated with ticlopidine and aspirin with the timing in those receiving coumadin and aspirin. A retrospective databank analysis was performed and 39 patients were identified who experienced stent thrombosis after successful coronary stent implantation. Of these, 21 had been treated with ticlopidine and aspirin and 18 with coumadin and aspirin therapy. The median time from stent implantation to stent thrombosis in the ticlopidine and aspirin group was 12 hours (interquartile range 6 to 72 hours) compared with 4 days in the coumadin and aspirin group (interquartile range 21 to 68 hours) (p |
| doi_str_mv | 10.1016/S0002-9149(99)00005-3 |
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Little is known about the timing of stent thrombosis in patients treated with aspirin and ticlopidine. We compared the timing of coronary stent thrombosis in patients treated with ticlopidine and aspirin with the timing in those receiving coumadin and aspirin. A retrospective databank analysis was performed and 39 patients were identified who experienced stent thrombosis after successful coronary stent implantation. Of these, 21 had been treated with ticlopidine and aspirin and 18 with coumadin and aspirin therapy. The median time from stent implantation to stent thrombosis in the ticlopidine and aspirin group was 12 hours (interquartile range 6 to 72 hours) compared with 4 days in the coumadin and aspirin group (interquartile range 21 to 68 hours) (p <0.0001). There was no significant difference between the timing of stent thrombosis in patients treated with abciximab in addition to ticlopidine and aspirin (median 17 hours, interquartile range 6 to 29) versus ticlopidine and aspirin patients who did not receive abciximab (median 11 hours, interquartile range 9 to 12, p = 0.57). Thus, in patients who receive coronary stents, stent thrombosis occurs much earlier after the procedure in patients treated with ticlopidine and aspirin than in patients treated with anticoagulation therapy.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(99)00005-3</identifier><identifier>PMID: 10190510</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject><![CDATA[Angioplasty, Balloon, Coronary ; Anticoagulants - administration & dosage ; Aspirin ; Aspirin - administration & dosage ; Biological and medical sciences ; Cardiology ; Cardiovascular disease ; Coronary Angiography ; Coronary Disease - therapy ; Coronary Vessels ; Diseases of the cardiovascular system ; Drug therapy ; Drug Therapy, Combination ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Platelet Aggregation Inhibitors - administration & dosage ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Retrospective Studies ; Stents ; Stents - adverse effects ; Thrombosis - diagnostic imaging ; Thrombosis - etiology ; Thrombosis - prevention & control ; Ticlopidine - administration & dosage ; Time Factors ; Warfarin - administration & dosage]]></subject><ispartof>The American journal of cardiology, 1999-04, Vol.83 (7), p.1006-1011</ispartof><rights>1999 Excerpta Medica Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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Little is known about the timing of stent thrombosis in patients treated with aspirin and ticlopidine. We compared the timing of coronary stent thrombosis in patients treated with ticlopidine and aspirin with the timing in those receiving coumadin and aspirin. A retrospective databank analysis was performed and 39 patients were identified who experienced stent thrombosis after successful coronary stent implantation. Of these, 21 had been treated with ticlopidine and aspirin and 18 with coumadin and aspirin therapy. The median time from stent implantation to stent thrombosis in the ticlopidine and aspirin group was 12 hours (interquartile range 6 to 72 hours) compared with 4 days in the coumadin and aspirin group (interquartile range 21 to 68 hours) (p <0.0001). There was no significant difference between the timing of stent thrombosis in patients treated with abciximab in addition to ticlopidine and aspirin (median 17 hours, interquartile range 6 to 29) versus ticlopidine and aspirin patients who did not receive abciximab (median 11 hours, interquartile range 9 to 12, p = 0.57). Thus, in patients who receive coronary stents, stent thrombosis occurs much earlier after the procedure in patients treated with ticlopidine and aspirin than in patients treated with anticoagulation therapy.</description><subject>Angioplasty, Balloon, Coronary</subject><subject>Anticoagulants - administration & dosage</subject><subject>Aspirin</subject><subject>Aspirin - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - therapy</subject><subject>Coronary Vessels</subject><subject>Diseases of the cardiovascular system</subject><subject>Drug therapy</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Platelet Aggregation Inhibitors - administration & dosage</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Retrospective Studies</subject><subject>Stents</subject><subject>Stents - adverse effects</subject><subject>Thrombosis - diagnostic imaging</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - prevention & control</subject><subject>Ticlopidine - administration & dosage</subject><subject>Time Factors</subject><subject>Warfarin - administration & dosage</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo7rj6E5QgInpoTSb9VadFFr9gwYPjOVRXEjdLd9ImGcV_b2ZnUPHiKVR46s2bh7HHUrySQvavPwshtg3IFl4AvKyD6Bp1h23kOEAjQaq7bPMbOWMPcr6po5Rdf5-d1QQQnRQbttv5xYevPDpOMcWA6SfPxYbCy3WKyxSzz9wHvmLx9TbzkiwWa_gPX6558TTH1RsfLMdgOObVJx8esnsO52wfnc5z9uXd293lh-bq0_uPl2-uGmrlUBpFZAQ6ItcBudF1ZHDCFieYxs4M0AIOcgvSkUNT-07bqXNitL2stAJU5-z5MXdN8dve5qIXn8nOMwYb91n30Pd9_X4Fn_4D3sR9CrWb3iqhetXCAeqOEKWYc7JOr8kvVYiWQh-c61vn-iBUA-hb51rVvSen8P20WPPX1lFyBZ6dAMyEs0sYyOc_3KDUKA7vXxwxW5V99zbpTNU5WeOTpaJN9P9p8guRJp8Z</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Wilson, Stephanie H</creator><creator>Rihal, Charanjit S</creator><creator>Bell, Malcolm R</creator><creator>Velianou, James L</creator><creator>Holmes, David R</creator><creator>Berger, Peter B</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Timing of coronary stent thrombosis in patients treated with ticlopidine and aspirin</title><author>Wilson, Stephanie H ; Rihal, Charanjit S ; Bell, Malcolm R ; Velianou, James L ; Holmes, David R ; Berger, Peter B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3ccd0afccf59cf8f5cdaba4ab9b85d7949a71291fcfad905b2b5f08e61cf839a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Angioplasty, Balloon, Coronary</topic><topic>Anticoagulants - administration & dosage</topic><topic>Aspirin</topic><topic>Aspirin - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - therapy</topic><topic>Coronary Vessels</topic><topic>Diseases of the cardiovascular system</topic><topic>Drug therapy</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Platelet Aggregation Inhibitors - administration & dosage</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Retrospective Studies</topic><topic>Stents</topic><topic>Stents - adverse effects</topic><topic>Thrombosis - diagnostic imaging</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - prevention & control</topic><topic>Ticlopidine - administration & dosage</topic><topic>Time Factors</topic><topic>Warfarin - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, Stephanie H</creatorcontrib><creatorcontrib>Rihal, Charanjit S</creatorcontrib><creatorcontrib>Bell, Malcolm R</creatorcontrib><creatorcontrib>Velianou, James L</creatorcontrib><creatorcontrib>Holmes, David R</creatorcontrib><creatorcontrib>Berger, Peter B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, Stephanie H</au><au>Rihal, Charanjit S</au><au>Bell, Malcolm R</au><au>Velianou, James L</au><au>Holmes, David R</au><au>Berger, Peter B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Timing of coronary stent thrombosis in patients treated with ticlopidine and aspirin</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>83</volume><issue>7</issue><spage>1006</spage><epage>1011</epage><pages>1006-1011</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>In patients receiving coronary stents treated with aspirin and coumadin, the peak incidence of stent thrombosis occurs on the fifth and sixth days following the implantation procedure. Little is known about the timing of stent thrombosis in patients treated with aspirin and ticlopidine. We compared the timing of coronary stent thrombosis in patients treated with ticlopidine and aspirin with the timing in those receiving coumadin and aspirin. A retrospective databank analysis was performed and 39 patients were identified who experienced stent thrombosis after successful coronary stent implantation. Of these, 21 had been treated with ticlopidine and aspirin and 18 with coumadin and aspirin therapy. The median time from stent implantation to stent thrombosis in the ticlopidine and aspirin group was 12 hours (interquartile range 6 to 72 hours) compared with 4 days in the coumadin and aspirin group (interquartile range 21 to 68 hours) (p <0.0001). There was no significant difference between the timing of stent thrombosis in patients treated with abciximab in addition to ticlopidine and aspirin (median 17 hours, interquartile range 6 to 29) versus ticlopidine and aspirin patients who did not receive abciximab (median 11 hours, interquartile range 9 to 12, p = 0.57). Thus, in patients who receive coronary stents, stent thrombosis occurs much earlier after the procedure in patients treated with ticlopidine and aspirin than in patients treated with anticoagulation therapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10190510</pmid><doi>10.1016/S0002-9149(99)00005-3</doi><tpages>6</tpages></addata></record> |
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| subjects | Angioplasty, Balloon, Coronary Anticoagulants - administration & dosage Aspirin Aspirin - administration & dosage Biological and medical sciences Cardiology Cardiovascular disease Coronary Angiography Coronary Disease - therapy Coronary Vessels Diseases of the cardiovascular system Drug therapy Drug Therapy, Combination Female Humans Male Medical sciences Middle Aged Platelet Aggregation Inhibitors - administration & dosage Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Retrospective Studies Stents Stents - adverse effects Thrombosis - diagnostic imaging Thrombosis - etiology Thrombosis - prevention & control Ticlopidine - administration & dosage Time Factors Warfarin - administration & dosage |
| title | Timing of coronary stent thrombosis in patients treated with ticlopidine and aspirin |
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