Inhibition of Cyclooxygenase-2 Expression by 4-Trifluoromethyl Derivatives of Salicylate, Triflusal, and Its Deacetylated Metabolite, 2-Hydroxy-4-trifluoromethylbenzoic Acid

The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized. When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared wi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmacology 1999-04, Vol.55 (4), p.753-760
Hauptverfasser:	Fernández de Arriba, Alberto, Cavalcanti, Fernando, Miralles, Agustí, Bayón, Yolanda, Alonso, Andrés, Merlos, Manuel, García-Rafanell, Julián, Forn, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspirin - pharmacology Cells, Cultured Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - pharmacology Dinoprostone - biosynthesis Dinoprostone - metabolism Humans Inflammation - drug therapy Isoenzymes - biosynthesis Isoenzymes - genetics Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lipopolysaccharides - pharmacology Male Membrane Proteins NF-kappa B - metabolism Platelet Aggregation Inhibitors - pharmacology Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Rats Rats, Inbred Lew Salicylates - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!