Increase in matrix metalloproteinase-9 levels in the rat medial prefrontal cortex after cocaine reinstatement of conditioned place preference

Recently we have shown that inhibition of matrix metalloproteinase (MMP) activity suppresses the reinstatement of cocaine‐primed conditioned place preference (CPP) in rats. Here we explored whether cocaine‐primed reinstatement was associated with increased activity of the gelatinases, MMP‐2 or MMP‐9...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2008-12, Vol.62 (12), p.886-889
Hauptverfasser:	Brown, Travis E., Forquer, Melissa R., Harding, Joseph W., Wright, John W., Sorg, Barbara A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cocaine Cocaine - administration & dosage Conditioning, Operant - drug effects Conditioning, Operant - physiology Enzyme Activation - drug effects Enzyme Activation - physiology extinction Male matrix metalloproteinase Matrix Metalloproteinase 9 - metabolism medial prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - enzymology Rats Rats, Sprague-Dawley Reinforcement (Psychology) reinstatement Up-Regulation - drug effects Up-Regulation - physiology
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