Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy
Postoperative pain is the dominating complaint and the primary reason for prolonged convalescence after laparoscopic cholecystectomy. We have evaluated the efficacy of a single preoperative dose of pregabalin for attenuating postoperative pain and fentanyl consumption after laparoscopic cholecystect...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 2008-11, Vol.101 (5), p.700-704 |
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| creator | Agarwal, A. Gautam, S. Gupta, D. Agarwal, S. Singh, P.K. Singh, U. |
| description | Postoperative pain is the dominating complaint and the primary reason for prolonged convalescence after laparoscopic cholecystectomy. We have evaluated the efficacy of a single preoperative dose of pregabalin for attenuating postoperative pain and fentanyl consumption after laparoscopic cholecystectomy.
Sixty adults (16–60 yr), ASA physical status I and II, of either sex undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized placebo controlled, double-blind study. Subjects were divided into two groups of 30 each to receive either a matching placebo or pregabalin 150 mg, administered orally 1 h before surgery. Postoperative pain (static and dynamic) was assessed by a 100 mm visual analogue scale, where 0, no pain; 100, worst imaginable pain. Subjects received patient-controlled i.v. fentanyl analgesia during the postoperative period. Results were analysed by Student's t-test, χ2 test, Mann–Whitney U-test, and Fisher's exact test.
Postoperative pain (static and dynamic) and postoperative patient-controlled fentanyl consumption were reduced in the pregabalin group compared with the placebo group (P |
| doi_str_mv | 10.1093/bja/aen244 |
| format | Article |
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Sixty adults (16–60 yr), ASA physical status I and II, of either sex undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized placebo controlled, double-blind study. Subjects were divided into two groups of 30 each to receive either a matching placebo or pregabalin 150 mg, administered orally 1 h before surgery. Postoperative pain (static and dynamic) was assessed by a 100 mm visual analogue scale, where 0, no pain; 100, worst imaginable pain. Subjects received patient-controlled i.v. fentanyl analgesia during the postoperative period. Results were analysed by Student's t-test, χ2 test, Mann–Whitney U-test, and Fisher's exact test.
Postoperative pain (static and dynamic) and postoperative patient-controlled fentanyl consumption were reduced in the pregabalin group compared with the placebo group (P<0.05). Side-effects were similar in both groups.
A single preoperative oral dose of pregabalin 150 mg is an effective method for reducing postoperative pain and fentanyl consumption in patients undergoing laparoscopic cholecystectomy.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/aen244</identifier><identifier>PMID: 18716003</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject><![CDATA[Administration, Oral ; Adolescent ; Adult ; analgesia ; analgesia, postoperative ; analgesia, pre-emptive ; analgesics non-opioid ; Analgesics, Non-Narcotic - administration & dosage ; Analgesics, Opioid - administration & dosage ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cholecystectomy, Laparoscopic ; Double-Blind Method ; Drug Administration Schedule ; Female ; Fentanyl - administration & dosage ; gamma-Aminobutyric Acid - administration & dosage ; gamma-Aminobutyric Acid - analogs & derivatives ; Humans ; Male ; Medical sciences ; Middle Aged ; pain ; Pain Measurement - methods ; pain, postoperative ; Pain, Postoperative - prevention & control ; postoperative ; pre-emptive ; Preanesthetic Medication - methods ; Pregabalin ; Prospective Studies]]></subject><ispartof>British journal of anaesthesia : BJA, 2008-11, Vol.101 (5), p.700-704</ispartof><rights>2008 British Journal of Anaesthesia</rights><rights>The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2008</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Nov 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c582t-2ec3884cbb915f062499dc33cb9c691e0773e118b888b0f0fd79e3db56e21ec73</citedby><cites>FETCH-LOGICAL-c582t-2ec3884cbb915f062499dc33cb9c691e0773e118b888b0f0fd79e3db56e21ec73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20814597$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18716003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agarwal, A.</creatorcontrib><creatorcontrib>Gautam, S.</creatorcontrib><creatorcontrib>Gupta, D.</creatorcontrib><creatorcontrib>Agarwal, S.</creatorcontrib><creatorcontrib>Singh, P.K.</creatorcontrib><creatorcontrib>Singh, U.</creatorcontrib><title>Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><addtitle>Br J Anaesth</addtitle><description>Postoperative pain is the dominating complaint and the primary reason for prolonged convalescence after laparoscopic cholecystectomy. We have evaluated the efficacy of a single preoperative dose of pregabalin for attenuating postoperative pain and fentanyl consumption after laparoscopic cholecystectomy.
Sixty adults (16–60 yr), ASA physical status I and II, of either sex undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized placebo controlled, double-blind study. Subjects were divided into two groups of 30 each to receive either a matching placebo or pregabalin 150 mg, administered orally 1 h before surgery. Postoperative pain (static and dynamic) was assessed by a 100 mm visual analogue scale, where 0, no pain; 100, worst imaginable pain. Subjects received patient-controlled i.v. fentanyl analgesia during the postoperative period. Results were analysed by Student's t-test, χ2 test, Mann–Whitney U-test, and Fisher's exact test.
Postoperative pain (static and dynamic) and postoperative patient-controlled fentanyl consumption were reduced in the pregabalin group compared with the placebo group (P<0.05). Side-effects were similar in both groups.
A single preoperative oral dose of pregabalin 150 mg is an effective method for reducing postoperative pain and fentanyl consumption in patients undergoing laparoscopic cholecystectomy.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>analgesia</subject><subject>analgesia, postoperative</subject><subject>analgesia, pre-emptive</subject><subject>analgesics non-opioid</subject><subject>Analgesics, Non-Narcotic - administration & dosage</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cholecystectomy, Laparoscopic</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Fentanyl - administration & dosage</subject><subject>gamma-Aminobutyric Acid - administration & dosage</subject><subject>gamma-Aminobutyric Acid - analogs & derivatives</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>pain</subject><subject>Pain Measurement - methods</subject><subject>pain, postoperative</subject><subject>Pain, Postoperative - prevention & control</subject><subject>postoperative</subject><subject>pre-emptive</subject><subject>Preanesthetic Medication - methods</subject><subject>Pregabalin</subject><subject>Prospective Studies</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90UGL1DAUB_AgijuuXvwAUgQ9CHXz2rRJjuuwuuKKe1AQL-E1fV0zdpqatINz8qubpcMOiHgKJL_3XpI_Y0-Bvwauy7Nmg2dIQyHEPbYCISGvpYT7bMU5lznXUJywRzFuOAdZ6OohOwEloea8XLHfFzvsZ5ycHzLfZZhFN9z0lI2B_EghHewoa32k29O0eYMN9m7IOh8ynCYajrWjj9OxZsSksJsoZD2OGHy0fnQ2s999T3YfJ7KT3-4fswcd9pGeHNZT9uXtxef1ZX716d379flVbitVTHlBtlRK2KbRUHW8LoTWrS1L22hbayAuZUkAqlFKNbzjXSs1lW1T1VQAWVmespdL3zH4nzPFyWxdtNT3OJCfo6l1XUkhIMHnf8GNn8OQ7mZASwVCiSqhVwuy6V0xUGfG4LYY9ga4uc3EpEzMkknCzw4d52ZL7ZEeQkjgxQFgtNh3AQfr4p0reJpaaXl0fh7_PzBfnEu__OtOYvhhalnKylx-_Wau9QfxZn0N5mPyYvGUAtg5CiZaR4Ol1oWUkmm9-9eYP7wnxZQ</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Agarwal, A.</creator><creator>Gautam, S.</creator><creator>Gupta, D.</creator><creator>Agarwal, S.</creator><creator>Singh, P.K.</creator><creator>Singh, U.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy</title><author>Agarwal, A. ; Gautam, S. ; Gupta, D. ; Agarwal, S. ; Singh, P.K. ; Singh, U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-2ec3884cbb915f062499dc33cb9c691e0773e118b888b0f0fd79e3db56e21ec73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>analgesia</topic><topic>analgesia, postoperative</topic><topic>analgesia, pre-emptive</topic><topic>analgesics non-opioid</topic><topic>Analgesics, Non-Narcotic - administration & dosage</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cholecystectomy, Laparoscopic</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Fentanyl - administration & dosage</topic><topic>gamma-Aminobutyric Acid - administration & dosage</topic><topic>gamma-Aminobutyric Acid - analogs & derivatives</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>pain</topic><topic>Pain Measurement - methods</topic><topic>pain, postoperative</topic><topic>Pain, Postoperative - prevention & control</topic><topic>postoperative</topic><topic>pre-emptive</topic><topic>Preanesthetic Medication - methods</topic><topic>Pregabalin</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agarwal, A.</creatorcontrib><creatorcontrib>Gautam, S.</creatorcontrib><creatorcontrib>Gupta, D.</creatorcontrib><creatorcontrib>Agarwal, S.</creatorcontrib><creatorcontrib>Singh, P.K.</creatorcontrib><creatorcontrib>Singh, U.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agarwal, A.</au><au>Gautam, S.</au><au>Gupta, D.</au><au>Agarwal, S.</au><au>Singh, P.K.</au><au>Singh, U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>101</volume><issue>5</issue><spage>700</spage><epage>704</epage><pages>700-704</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Postoperative pain is the dominating complaint and the primary reason for prolonged convalescence after laparoscopic cholecystectomy. We have evaluated the efficacy of a single preoperative dose of pregabalin for attenuating postoperative pain and fentanyl consumption after laparoscopic cholecystectomy.
Sixty adults (16–60 yr), ASA physical status I and II, of either sex undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized placebo controlled, double-blind study. Subjects were divided into two groups of 30 each to receive either a matching placebo or pregabalin 150 mg, administered orally 1 h before surgery. Postoperative pain (static and dynamic) was assessed by a 100 mm visual analogue scale, where 0, no pain; 100, worst imaginable pain. Subjects received patient-controlled i.v. fentanyl analgesia during the postoperative period. Results were analysed by Student's t-test, χ2 test, Mann–Whitney U-test, and Fisher's exact test.
Postoperative pain (static and dynamic) and postoperative patient-controlled fentanyl consumption were reduced in the pregabalin group compared with the placebo group (P<0.05). Side-effects were similar in both groups.
A single preoperative oral dose of pregabalin 150 mg is an effective method for reducing postoperative pain and fentanyl consumption in patients undergoing laparoscopic cholecystectomy.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18716003</pmid><doi>10.1093/bja/aen244</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Oral Adolescent Adult analgesia analgesia, postoperative analgesia, pre-emptive analgesics non-opioid Analgesics, Non-Narcotic - administration & dosage Analgesics, Opioid - administration & dosage Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cholecystectomy, Laparoscopic Double-Blind Method Drug Administration Schedule Female Fentanyl - administration & dosage gamma-Aminobutyric Acid - administration & dosage gamma-Aminobutyric Acid - analogs & derivatives Humans Male Medical sciences Middle Aged pain Pain Measurement - methods pain, postoperative Pain, Postoperative - prevention & control postoperative pre-emptive Preanesthetic Medication - methods Pregabalin Prospective Studies |
| title | Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy |
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