Requirement of the carboxy-terminal domain of RNA polymerase II for the transcriptional activation of chromosomal c-fos and hsp70A genes

The carboxy-terminal domain of the large subunit of mouse and human RNA polymerase II contains 52 repeats of a heptapeptide which are the targets for a variety of kinases. We have used an α-amanitin resistant form of the large subunit of pol II to study the role of the carboxy-terminal domain in the...

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Veröffentlicht in:	FEBS letters 1999-03, Vol.446 (1), p.173-176
Hauptverfasser:	Meininghaus, Mark, Eick, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carboxy-terminal domain Carboxylic Acids Cell Line Genes, fos HSP70 Heat-Shock Proteins - genetics Humans Mice RNA polymerase II RNA Polymerase II - chemistry RNA Polymerase II - genetics RNA Polymerase II - metabolism Sequence Deletion Transcription Transcriptional Activation α-Amanitin
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