Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene

The genomic organization of the heparin cofactor II (HCII) gene from rat and mouse was investigated and compared with their human counterpart. The genes share a common core structure consisting of five exons interrupted by four introns, but the mouse and rat gene reveal individual additional feature...

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Veröffentlicht in:	Gene 1999-03, Vol.229 (1), p.137-144
Hauptverfasser:	Kamp, Paul-Bertram, Ragg, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Amino Acid Sequence Animals Antithrombins - genetics Base Sequence Cloning, Molecular Evolution of genes Evolution, Molecular Exons Heparin cofactor II Heparin Cofactor II - chemistry Heparin Cofactor II - genetics Humans Introns Leuserpin 2 Liver - metabolism Mice Molecular Sequence Data Oligodeoxyribonucleotides - genetics Polymorphism, Restriction Fragment Length Rats RNA Splicing - genetics RNA, Messenger - genetics Sequence Alignment Serine Proteinase Inhibitors - genetics Serpins Splicing
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