Organization of the gene for gelatin-binding protein (GBP28)
GBP28 is a novel human plasma gelatin-binding protein that is encoded by apM1 mRNA, expressed specifically in adipose tissue. Three overlapping clones (two lambda clones and one BAC clone) containing the human plasma gelatin-binding protein (GBP28) gene were isolated and characterized. The GBP28 gen...
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| Veröffentlicht in: | Gene 1999-03, Vol.229 (1), p.67-73 |
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| container_title | Gene |
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| creator | Saito, Kiyomi Tobe, Takashi Minoshima, Shinsei Asakawa, Shuichi Sumiya, Junichi Yoda, Madoka Nakano, Yasuko Shimizu, Nobuyoshi Tomita, Motowo |
| description | GBP28 is a novel human plasma gelatin-binding protein that is encoded by apM1 mRNA, expressed specifically in adipose tissue. Three overlapping clones (two lambda clones and one BAC clone) containing the human plasma gelatin-binding protein (GBP28) gene were isolated and characterized. The
GBP28 gene spans 16
kb and is composed of three exons from 18
bp to 4277
bp in size with consensus splice sites. The sizes of the two introns were 0.8 and 12
kb, respectively. The gene's regulatory sequences contain putative promoter elements, but no typical TATA box.
The third exon of this gene contains a long 3′-untranslated sequence containing three Alu repeats. The exon–intron organization of this gene was very similar to that of
obese gene, encoding leptin. We also report the chromosome mapping of this gene by fluorescence in situ hybridization (FISH) using a genomic DNA fragment as a probe. The
GBP28 gene was located on human chromosome 3q27. The nucleotide sequence data reported in this paper will appear in the DDBJ/EMBL/GenBank nucleotide sequence databases with the accession numbers ABO12163, ABO12164 or ABO12165. |
| doi_str_mv | 10.1016/S0378-1119(99)00041-4 |
| format | Article |
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GBP28 gene spans 16
kb and is composed of three exons from 18
bp to 4277
bp in size with consensus splice sites. The sizes of the two introns were 0.8 and 12
kb, respectively. The gene's regulatory sequences contain putative promoter elements, but no typical TATA box.
The third exon of this gene contains a long 3′-untranslated sequence containing three Alu repeats. The exon–intron organization of this gene was very similar to that of
obese gene, encoding leptin. We also report the chromosome mapping of this gene by fluorescence in situ hybridization (FISH) using a genomic DNA fragment as a probe. The
GBP28 gene was located on human chromosome 3q27. The nucleotide sequence data reported in this paper will appear in the DDBJ/EMBL/GenBank nucleotide sequence databases with the accession numbers ABO12163, ABO12164 or ABO12165.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/S0378-1119(99)00041-4</identifier><identifier>PMID: 10095105</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adiponectin ; Alu Elements - genetics ; Animals ; Base Sequence ; Carrier Proteins - genetics ; Chromosome 3 ; Chromosome Mapping ; Chromosomes, Human, Pair 3 - genetics ; Cloning, Molecular ; Exons - genetics ; GBP28 ; Gene structure ; Guinea Pigs ; Humans ; In Situ Hybridization, Fluorescence ; Intercellular Signaling Peptides and Proteins ; Introns - genetics ; Leptin ; Molecular Sequence Data ; Promoter Regions, Genetic - genetics ; Proteins - genetics</subject><ispartof>Gene, 1999-03, Vol.229 (1), p.67-73</ispartof><rights>1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-8f8f6cc26cb9d7bfc7a35c5a94119f790103f66ae9b3030da62fa343a46bc1953</citedby><cites>FETCH-LOGICAL-c458t-8f8f6cc26cb9d7bfc7a35c5a94119f790103f66ae9b3030da62fa343a46bc1953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-1119(99)00041-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10095105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Kiyomi</creatorcontrib><creatorcontrib>Tobe, Takashi</creatorcontrib><creatorcontrib>Minoshima, Shinsei</creatorcontrib><creatorcontrib>Asakawa, Shuichi</creatorcontrib><creatorcontrib>Sumiya, Junichi</creatorcontrib><creatorcontrib>Yoda, Madoka</creatorcontrib><creatorcontrib>Nakano, Yasuko</creatorcontrib><creatorcontrib>Shimizu, Nobuyoshi</creatorcontrib><creatorcontrib>Tomita, Motowo</creatorcontrib><title>Organization of the gene for gelatin-binding protein (GBP28)</title><title>Gene</title><addtitle>Gene</addtitle><description>GBP28 is a novel human plasma gelatin-binding protein that is encoded by apM1 mRNA, expressed specifically in adipose tissue. Three overlapping clones (two lambda clones and one BAC clone) containing the human plasma gelatin-binding protein (GBP28) gene were isolated and characterized. The
GBP28 gene spans 16
kb and is composed of three exons from 18
bp to 4277
bp in size with consensus splice sites. The sizes of the two introns were 0.8 and 12
kb, respectively. The gene's regulatory sequences contain putative promoter elements, but no typical TATA box.
The third exon of this gene contains a long 3′-untranslated sequence containing three Alu repeats. The exon–intron organization of this gene was very similar to that of
obese gene, encoding leptin. We also report the chromosome mapping of this gene by fluorescence in situ hybridization (FISH) using a genomic DNA fragment as a probe. The
GBP28 gene was located on human chromosome 3q27. The nucleotide sequence data reported in this paper will appear in the DDBJ/EMBL/GenBank nucleotide sequence databases with the accession numbers ABO12163, ABO12164 or ABO12165.</description><subject>Adiponectin</subject><subject>Alu Elements - genetics</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Carrier Proteins - genetics</subject><subject>Chromosome 3</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 3 - genetics</subject><subject>Cloning, Molecular</subject><subject>Exons - genetics</subject><subject>GBP28</subject><subject>Gene structure</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Introns - genetics</subject><subject>Leptin</subject><subject>Molecular Sequence Data</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Proteins - genetics</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFFLwzAQx4Mobk4_gtIn2R6ql6ZJGxBEh05hMEF9DmmazMiWzqQT9NObrSK-7ekO7nf3P34InWK4wIDZ5TOQokwxxnzI-QgAcpzme6iPy4KnAKTcR_0_pIeOQniPEFCaHaIeBuAUA-2jq5mfS2e_ZWsblzQmad90MtdOJ6bxsVnEgUsr62rr5snKN622LhlObp-ycnSMDoxcBH3yWwfo9f7uZfyQTmeTx_HNNFU5Ldu0NKVhSmVMVbwuKqMKSaiikufxNVNwwEAMY1LzigCBWrLMSJITmbNKYU7JAJ13d2P-x1qHVixtUHqxkE436yAYZ5SwDO8EcZEVWU6zCNIOVL4JwWsjVt4upf8SGMTGr9j6FRt5gnOx9SvyuHf2G7Culrr-t9UJjcB1B-jo49NqL4Ky2ildW69VK-rG7oj4AbR-iAo</recordid><startdate>19990318</startdate><enddate>19990318</enddate><creator>Saito, Kiyomi</creator><creator>Tobe, Takashi</creator><creator>Minoshima, Shinsei</creator><creator>Asakawa, Shuichi</creator><creator>Sumiya, Junichi</creator><creator>Yoda, Madoka</creator><creator>Nakano, Yasuko</creator><creator>Shimizu, Nobuyoshi</creator><creator>Tomita, Motowo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19990318</creationdate><title>Organization of the gene for gelatin-binding protein (GBP28)</title><author>Saito, Kiyomi ; Tobe, Takashi ; Minoshima, Shinsei ; Asakawa, Shuichi ; Sumiya, Junichi ; Yoda, Madoka ; Nakano, Yasuko ; Shimizu, Nobuyoshi ; Tomita, Motowo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-8f8f6cc26cb9d7bfc7a35c5a94119f790103f66ae9b3030da62fa343a46bc1953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adiponectin</topic><topic>Alu Elements - genetics</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Carrier Proteins - genetics</topic><topic>Chromosome 3</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 3 - genetics</topic><topic>Cloning, Molecular</topic><topic>Exons - genetics</topic><topic>GBP28</topic><topic>Gene structure</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Introns - genetics</topic><topic>Leptin</topic><topic>Molecular Sequence Data</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Kiyomi</creatorcontrib><creatorcontrib>Tobe, Takashi</creatorcontrib><creatorcontrib>Minoshima, Shinsei</creatorcontrib><creatorcontrib>Asakawa, Shuichi</creatorcontrib><creatorcontrib>Sumiya, Junichi</creatorcontrib><creatorcontrib>Yoda, Madoka</creatorcontrib><creatorcontrib>Nakano, Yasuko</creatorcontrib><creatorcontrib>Shimizu, Nobuyoshi</creatorcontrib><creatorcontrib>Tomita, Motowo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Kiyomi</au><au>Tobe, Takashi</au><au>Minoshima, Shinsei</au><au>Asakawa, Shuichi</au><au>Sumiya, Junichi</au><au>Yoda, Madoka</au><au>Nakano, Yasuko</au><au>Shimizu, Nobuyoshi</au><au>Tomita, Motowo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Organization of the gene for gelatin-binding protein (GBP28)</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>1999-03-18</date><risdate>1999</risdate><volume>229</volume><issue>1</issue><spage>67</spage><epage>73</epage><pages>67-73</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>GBP28 is a novel human plasma gelatin-binding protein that is encoded by apM1 mRNA, expressed specifically in adipose tissue. Three overlapping clones (two lambda clones and one BAC clone) containing the human plasma gelatin-binding protein (GBP28) gene were isolated and characterized. The
GBP28 gene spans 16
kb and is composed of three exons from 18
bp to 4277
bp in size with consensus splice sites. The sizes of the two introns were 0.8 and 12
kb, respectively. The gene's regulatory sequences contain putative promoter elements, but no typical TATA box.
The third exon of this gene contains a long 3′-untranslated sequence containing three Alu repeats. The exon–intron organization of this gene was very similar to that of
obese gene, encoding leptin. We also report the chromosome mapping of this gene by fluorescence in situ hybridization (FISH) using a genomic DNA fragment as a probe. The
GBP28 gene was located on human chromosome 3q27. The nucleotide sequence data reported in this paper will appear in the DDBJ/EMBL/GenBank nucleotide sequence databases with the accession numbers ABO12163, ABO12164 or ABO12165.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10095105</pmid><doi>10.1016/S0378-1119(99)00041-4</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0378-1119 |
| ispartof | Gene, 1999-03, Vol.229 (1), p.67-73 |
| issn | 0378-1119 1879-0038 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adiponectin Alu Elements - genetics Animals Base Sequence Carrier Proteins - genetics Chromosome 3 Chromosome Mapping Chromosomes, Human, Pair 3 - genetics Cloning, Molecular Exons - genetics GBP28 Gene structure Guinea Pigs Humans In Situ Hybridization, Fluorescence Intercellular Signaling Peptides and Proteins Introns - genetics Leptin Molecular Sequence Data Promoter Regions, Genetic - genetics Proteins - genetics |
| title | Organization of the gene for gelatin-binding protein (GBP28) |
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