Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel
Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel Lawrence Ang, Vachaspathi Palakodeti, Ahmer Khalid, Sotirios Tsimikas, Zaheib Idrees, Phillip Tran, Paul Clopton, Nayab Zafar, Guilherme Bromberg-Marin, Shahin Keramati, Ehti...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2008-09, Vol.52 (13), p.1052-1059 |
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| creator | Ang, Lawrence, BS Palakodeti, Vachaspathi, MD, FACC Khalid, Ahmer, BS Tsimikas, Sotirios, MD, FACC Idrees, Zaheib, BS Tran, Phillip, MD Clopton, Paul, MS Zafar, Nayab, MD Bromberg-Marin, Guilherme, MD Keramati, Shahin, MD, FACC Mahmud, Ehtisham, MD, FACC |
| description | Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel Lawrence Ang, Vachaspathi Palakodeti, Ahmer Khalid, Sotirios Tsimikas, Zaheib Idrees, Phillip Tran, Paul Clopton, Nayab Zafar, Guilherme Bromberg-Marin, Shahin Keramati, Ehtisham Mahmud A heterogeneous platelet reactivity response to clopidogrel exists. In this study, platelet reactivity was measured in 157 subjects (age 67.2 ± 12.2 years; 59.9% men) with cardiovascular disease utilizing a rapid platelet function assay. Among variables known to affect platelet reactivity, elevated plasma fibrinogen (≥375 mg/dl), diabetes mellitus, and increased body mass index (BMI) (≥25 kg/m2 ) were associated with lower platelet inhibition (PI) with clopidogrel. After testing for interaction, significantly lower PI was observed only in diabetic patients with elevated plasma fibrinogen (≥375 mg/dl) while increased BMI (≥25 kg/m2 ) remained independently associated with lower PI regardless of diabetic status or fibrinogen level. |
| doi_str_mv | 10.1016/j.jacc.2008.05.054 |
| format | Article |
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In this study, platelet reactivity was measured in 157 subjects (age 67.2 ± 12.2 years; 59.9% men) with cardiovascular disease utilizing a rapid platelet function assay. Among variables known to affect platelet reactivity, elevated plasma fibrinogen (≥375 mg/dl), diabetes mellitus, and increased body mass index (BMI) (≥25 kg/m2 ) were associated with lower platelet inhibition (PI) with clopidogrel. After testing for interaction, significantly lower PI was observed only in diabetic patients with elevated plasma fibrinogen (≥375 mg/dl) while increased BMI (≥25 kg/m2 ) remained independently associated with lower PI regardless of diabetic status or fibrinogen level.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2008.05.054</identifier><identifier>PMID: 18848137</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Blood ; Body Mass Index ; Cardiology ; Cardiovascular ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - metabolism ; clopidogrel ; Diabetes Complications - drug therapy ; Diabetes Complications - metabolism ; Diabetes Complications - physiopathology ; diabetes mellitus ; Female ; fibrinogen ; Fibrinogen - metabolism ; Heart attacks ; Humans ; Internal Medicine ; Laboratories ; Male ; Middle Aged ; platelet aggregation ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - pharmacology ; Platelet Aggregation Inhibitors - therapeutic use ; Platelet Function Tests ; Prospective Studies ; Ticlopidine - analogs & derivatives ; Ticlopidine - pharmacology ; Ticlopidine - therapeutic use</subject><ispartof>Journal of the American College of Cardiology, 2008-09, Vol.52 (13), p.1052-1059</ispartof><rights>American College of Cardiology Foundation</rights><rights>2008 American College of Cardiology Foundation</rights><rights>Copyright Elsevier Limited Sep 23, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-ec098d53aa6762d1292bc7b3e80169c8adccc04b837476501506a713c3bf16713</citedby><cites>FETCH-LOGICAL-c517t-ec098d53aa6762d1292bc7b3e80169c8adccc04b837476501506a713c3bf16713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2008.05.054$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18848137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ang, Lawrence, BS</creatorcontrib><creatorcontrib>Palakodeti, Vachaspathi, MD, FACC</creatorcontrib><creatorcontrib>Khalid, Ahmer, BS</creatorcontrib><creatorcontrib>Tsimikas, Sotirios, MD, FACC</creatorcontrib><creatorcontrib>Idrees, Zaheib, BS</creatorcontrib><creatorcontrib>Tran, Phillip, MD</creatorcontrib><creatorcontrib>Clopton, Paul, MS</creatorcontrib><creatorcontrib>Zafar, Nayab, MD</creatorcontrib><creatorcontrib>Bromberg-Marin, Guilherme, MD</creatorcontrib><creatorcontrib>Keramati, Shahin, MD, FACC</creatorcontrib><creatorcontrib>Mahmud, Ehtisham, MD, FACC</creatorcontrib><title>Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel Lawrence Ang, Vachaspathi Palakodeti, Ahmer Khalid, Sotirios Tsimikas, Zaheib Idrees, Phillip Tran, Paul Clopton, Nayab Zafar, Guilherme Bromberg-Marin, Shahin Keramati, Ehtisham Mahmud A heterogeneous platelet reactivity response to clopidogrel exists. In this study, platelet reactivity was measured in 157 subjects (age 67.2 ± 12.2 years; 59.9% men) with cardiovascular disease utilizing a rapid platelet function assay. Among variables known to affect platelet reactivity, elevated plasma fibrinogen (≥375 mg/dl), diabetes mellitus, and increased body mass index (BMI) (≥25 kg/m2 ) were associated with lower platelet inhibition (PI) with clopidogrel. After testing for interaction, significantly lower PI was observed only in diabetic patients with elevated plasma fibrinogen (≥375 mg/dl) while increased BMI (≥25 kg/m2 ) remained independently associated with lower PI regardless of diabetic status or fibrinogen level.</description><subject>Aged</subject><subject>Blood</subject><subject>Body Mass Index</subject><subject>Cardiology</subject><subject>Cardiovascular</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - drug therapy</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>clopidogrel</subject><subject>Diabetes Complications - drug therapy</subject><subject>Diabetes Complications - metabolism</subject><subject>Diabetes Complications - physiopathology</subject><subject>diabetes mellitus</subject><subject>Female</subject><subject>fibrinogen</subject><subject>Fibrinogen - metabolism</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laboratories</subject><subject>Male</subject><subject>Middle Aged</subject><subject>platelet aggregation</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Platelet Function Tests</subject><subject>Prospective Studies</subject><subject>Ticlopidine - analogs & derivatives</subject><subject>Ticlopidine - pharmacology</subject><subject>Ticlopidine - therapeutic use</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl2LEzEUhoMobl39A15IQPBuajKZfAyIUOquLlQUP_AyZDKnu6nppCaZLr3wv2_GFhb2QjhwcvG8LznnPQi9pGROCRVvN_ONsXZeE6LmhJdqHqEZ5VxVjLfyMZoRyXhFSSvP0LOUNoQQoWj7FJ1RpRpFmZyhvxce9iZDj796k7YGX7ouuiFcw4DN0OMPznSQIeHP4L3LY8KLCHiRUrDun-yXyzd4FW4h4qvhxnUuuzDgsJ78MnjI-BsYm93e5cMRXvqwc324juCfoydr4xO8OPVz9PPy4sfyU7X68vFquVhVllOZK7CkVT1nxggp6p7Wbd1Z2TFQZQ2tVaa31pKmU0w2UnBCORFGUmZZt6aiPM7Rm6PvLoY_I6Ssty7ZMpEZIIxJi1bwmrWkgK8fgJswxqH8TVPRFOfC8ELVR8rGkFKEtd5FtzXxoCnRUzR6o6do9BSNJrxUU0SvTtZjt4X-XnLKogDvjgCUTewdRJ2sg8FC7yLYrPvg_u___oHcejc4a_xvOEC6n0OnWhP9fTqO6TaIInUtJGd3Hx-0Nw</recordid><startdate>20080923</startdate><enddate>20080923</enddate><creator>Ang, Lawrence, BS</creator><creator>Palakodeti, Vachaspathi, MD, FACC</creator><creator>Khalid, Ahmer, BS</creator><creator>Tsimikas, Sotirios, MD, FACC</creator><creator>Idrees, Zaheib, BS</creator><creator>Tran, Phillip, MD</creator><creator>Clopton, Paul, MS</creator><creator>Zafar, Nayab, MD</creator><creator>Bromberg-Marin, Guilherme, MD</creator><creator>Keramati, Shahin, MD, FACC</creator><creator>Mahmud, Ehtisham, MD, FACC</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080923</creationdate><title>Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel</title><author>Ang, Lawrence, BS ; Palakodeti, Vachaspathi, MD, FACC ; Khalid, Ahmer, BS ; Tsimikas, Sotirios, MD, FACC ; Idrees, Zaheib, BS ; Tran, Phillip, MD ; Clopton, Paul, MS ; Zafar, Nayab, MD ; Bromberg-Marin, Guilherme, MD ; Keramati, Shahin, MD, FACC ; Mahmud, Ehtisham, MD, FACC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-ec098d53aa6762d1292bc7b3e80169c8adccc04b837476501506a713c3bf16713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Blood</topic><topic>Body Mass Index</topic><topic>Cardiology</topic><topic>Cardiovascular</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - drug therapy</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>clopidogrel</topic><topic>Diabetes Complications - drug therapy</topic><topic>Diabetes Complications - metabolism</topic><topic>Diabetes Complications - physiopathology</topic><topic>diabetes mellitus</topic><topic>Female</topic><topic>fibrinogen</topic><topic>Fibrinogen - metabolism</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Laboratories</topic><topic>Male</topic><topic>Middle Aged</topic><topic>platelet aggregation</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Platelet Function Tests</topic><topic>Prospective Studies</topic><topic>Ticlopidine - analogs & derivatives</topic><topic>Ticlopidine - pharmacology</topic><topic>Ticlopidine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ang, Lawrence, BS</creatorcontrib><creatorcontrib>Palakodeti, Vachaspathi, MD, FACC</creatorcontrib><creatorcontrib>Khalid, Ahmer, BS</creatorcontrib><creatorcontrib>Tsimikas, Sotirios, MD, FACC</creatorcontrib><creatorcontrib>Idrees, Zaheib, BS</creatorcontrib><creatorcontrib>Tran, Phillip, MD</creatorcontrib><creatorcontrib>Clopton, Paul, MS</creatorcontrib><creatorcontrib>Zafar, Nayab, MD</creatorcontrib><creatorcontrib>Bromberg-Marin, Guilherme, MD</creatorcontrib><creatorcontrib>Keramati, Shahin, MD, FACC</creatorcontrib><creatorcontrib>Mahmud, Ehtisham, MD, FACC</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ang, Lawrence, BS</au><au>Palakodeti, Vachaspathi, MD, FACC</au><au>Khalid, Ahmer, BS</au><au>Tsimikas, Sotirios, MD, FACC</au><au>Idrees, Zaheib, BS</au><au>Tran, Phillip, MD</au><au>Clopton, Paul, MS</au><au>Zafar, Nayab, MD</au><au>Bromberg-Marin, Guilherme, MD</au><au>Keramati, Shahin, MD, FACC</au><au>Mahmud, Ehtisham, MD, FACC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2008-09-23</date><risdate>2008</risdate><volume>52</volume><issue>13</issue><spage>1052</spage><epage>1059</epage><pages>1052-1059</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel Lawrence Ang, Vachaspathi Palakodeti, Ahmer Khalid, Sotirios Tsimikas, Zaheib Idrees, Phillip Tran, Paul Clopton, Nayab Zafar, Guilherme Bromberg-Marin, Shahin Keramati, Ehtisham Mahmud A heterogeneous platelet reactivity response to clopidogrel exists. In this study, platelet reactivity was measured in 157 subjects (age 67.2 ± 12.2 years; 59.9% men) with cardiovascular disease utilizing a rapid platelet function assay. Among variables known to affect platelet reactivity, elevated plasma fibrinogen (≥375 mg/dl), diabetes mellitus, and increased body mass index (BMI) (≥25 kg/m2 ) were associated with lower platelet inhibition (PI) with clopidogrel. After testing for interaction, significantly lower PI was observed only in diabetic patients with elevated plasma fibrinogen (≥375 mg/dl) while increased BMI (≥25 kg/m2 ) remained independently associated with lower PI regardless of diabetic status or fibrinogen level.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18848137</pmid><doi>10.1016/j.jacc.2008.05.054</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Blood Body Mass Index Cardiology Cardiovascular Cardiovascular Diseases - complications Cardiovascular Diseases - drug therapy Cardiovascular Diseases - metabolism clopidogrel Diabetes Complications - drug therapy Diabetes Complications - metabolism Diabetes Complications - physiopathology diabetes mellitus Female fibrinogen Fibrinogen - metabolism Heart attacks Humans Internal Medicine Laboratories Male Middle Aged platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use Platelet Function Tests Prospective Studies Ticlopidine - analogs & derivatives Ticlopidine - pharmacology Ticlopidine - therapeutic use |
| title | Elevated Plasma Fibrinogen and Diabetes Mellitus Are Associated With Lower Inhibition of Platelet Reactivity With Clopidogrel |
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