Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury

CV-159, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic++ + acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester, is a dihydropyridine derivative that blocks the L-type Ca2+ channel and inhibits the calmodulin (CaM)-dependent pathway. In this study, we examined the effects of CV-15...

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Veröffentlicht in:	Life sciences (1973) 1999, Vol.64 (10), p.869-878
Hauptverfasser:	Miyazaki, H, Tanaka, S, Fujii, Y, Shimizu, K, Nagashima, K, Kamibayashi, M, Uehara, T, Okuma, Y, Nomura, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Temperature - drug effects Brain Edema - prevention & control Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Cell Death - drug effects Cerebral Infarction - drug therapy Cerebral Infarction - metabolism Cerebral Infarction - pathology Dihydropyridines - pharmacology Dihydropyridines - therapeutic use Hemodynamics - drug effects Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - metabolism Ischemic Attack, Transient - pathology Male Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Nicardipine - pharmacology Nifedipine - pharmacology Rats Rats, Sprague-Dawley Sulfonamides - pharmacology Time Factors Water - metabolism
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